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Alexander Edward Perl, MDAssistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine
Contact information
713 BRB 2/3
421 Curie Blvd Philadelphia, PA 19104
Office: 215-573-8478
Fax: 215-573-7049
Education:
BA (Psychology) University of Rochester, 1993. MD (medicine) Mount Sinai School of Medicine, 1997.
Post-Graduate Training
Internal Medicine, University of California, San Francisco Department of Medicine 500 Parnassus Ave. San Francisco, CA 94143, 1997-2000. Medical Oncology, Johns Hopkins Hospital Department of Oncology 1650 Orleans St. Baltimore, MD 21231, 2001-2003.
Certifications
Permanent linkAmerican Board of Internal Medicine, 2000. American Board of Internal Medicine--Medical Oncology, 2003. Description of Research ExpertiseDr. Perl studies oncogenic signal transduction in acute myelogenous leukemia. Using a focus upon the phosphotidyl inositol 3' kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, he has performed clinical trials examining the strategy of inhibiting mTOR to promote chemotherapy response in AML. Laboratory correlation science on these studies was also performed by Dr. Perl, leading to improved methods for measuring mTOR activation in clinical samples via intracellular flow cytometry. Dr. Perl is currently exploring the use of flow cytometry for pharmacodynamic monitoring of signal transduction inhibitor response in hematologic malignancies as well as preclinical drug screening in cellular and murine xenotransplantation models.Description of Clinical ExpertiseDr. Perl specializes in the care of patients with acute leukemia (AML and ALL), myelodysplastic syndromes (MDS), and CML.
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