Division of Hematology/Oncology

Faculty

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Brendan M Weiss, M.D.

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Director, Penn Amyloidosis Program
Department: Medicine

Contact information
Abramson Cancer Center
Perelman Center for Advanced Medicine, West Pavilion, 2nd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 1-800-789-7366
Education:
BS (Biology)
Bucknell University, 1993.
MD (Medicine)
Uniformed Services University of the Health Sciences, Bethesda, MD, 1998.
Post-Graduate Training
Intern in Medicine, Brooke Army Medical Center (Ft. Sam Houston, TX) , 1998-1999.
Resident in Medicine, Brooke Army Medical Center, 1999-2001.
Fellow in Hematology-Oncology, National Capitol Consortium/Walter Reed Army Medical Center (Washington, DC), 2001-2004.
Medical Management of Nuclear, Chemical and Biological Casualties Course, U.S. Army Research Institute of Infectious Diseases, 2001-2001.
Research Fellow, Department of Blood Research, Walter Reed Army Institute of Research (Silver Spring, MD) , 2003-2004.
Captain’s Career Course, U.S. Army Medical Department Center and School, 2005-2005.
Program Director’s Course, National Capitol Consortium/Uniformed Services University of the Health Sciences, 2008-2008.
Drug Development Externship, Investigational Drug Branch, Cancer Therapy Evaluation Program, National Cancer Institute, 2008-2008.
Certifications
American Board of Internal Medicine (Internal Medicine), 2001.
American Board of Internal Medicine (Hematology), 2004.
American Board of Internal Medicine (Medical Oncology), 2006.
American Board of Internal Medicine (Internal Medicine) (Recertification), 2011.
American Board of Internal Medicine (Hematology) (Recertification), 2014.
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Description of Clinical Expertise

I am interested in the evaluation and management of patients with multiple myeloma, AL amyloidosis, and Waldenstrom's macroglobulinemia. I have a particular interest in the evaluation and management of myeloma precursor states, monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). In addition, I am interested in the other paraprotein-associated diseases such as monoclonal gammopathy of renal significance (MGRS), paraprotein associated neuropathy, cryoglobulinemia, POEMS syndrome and others.

Description of Research Expertise

I am a hematologist-oncologist with a specific research and clinical interest in plasma cell disorders and related dysproteinemias: multiple myeloma, immunoglobulin light chain (AL) amyloidosis, and Waldenstrom’s macroglobulinemia.

I also lead the multi-disciplinary Penn Amyloidosis Program. This is a cross-disciplinary program involving clinicians with expertise in amyloidosis from cardiology, nephrology, pathology and other disciplines.

I am involved in clinical, translational and epidemiologic research throughout the spectrum of plasma cell disorders. My primary research focus is on the myeloma precursor states: monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). I have previously established that both multiple myeloma (Weiss Blood 2009) and AL amyloidosis (Weiss J Clin Oncol 2014) have precursor states that are detectable for many years prior to diagnosis. I have also validated biomarkers for ultra-high risk SMM (Waxman Leukemia 2014) that have contributed to changing the diagnostic criteria for multiple myeloma requiring treatment (Rajkumar Lancet Oncol 2014).

I am currently performing trials to develop and test novel biomarkers for progression in the myeloma precursor states (MGUS and SMM). I am also participating in trials of early intervention in high risk SMM.

I am also conducting trials of novel agents for AL amyloidosis and relapsed and refractory multiple myeloma.

Selected Publications

Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritits E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jaganath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Laheurta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BGM, San Miguel JF: International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15: e538-48, Oct 2014.

Weiss BM, Hebreo J, Cordaro DV, Roschewski MJ, Baker TP, Abbott KC, Olson SW: Increased Serum Free Light Chains Precede the Presentation of Immunoglobulin Light Chain Amyloidosis. J Clin Oncol 32(25): 2699-704, Sep 2014.

Waxman AJ, Mick R, Garfall AL, Cohen A, Vogl DT, Stadtmauer EA, Weiss BM: Classifying ultra-high risk smoldering myeloma. Leukemia Nov 2014.

Weiss BM: Multiethnic myeloma. Blood 121(16): 3062-4, Apr 2013.

Fermand JP, Bridoux F, Kyle RA, Kastritis E, Weiss BM, Cook MA, Drayson MT, Dispenzieri A, Leung N; International Kidney and Monoclonal Gammopathy Research Group.: How I treat monoclonal gammopathy of renal significance (MGRS). Blood 122(22): 3583-90, Nov 2013.

Minter AR, Simpson H, Weiss BM, Landgren O: Bone Disease From Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma: Pathogenesis, Interventions, and Future Opportunities. Seminars in Hematology 48(1): 55-65, Jan 2011.

Weiss BM, Minter A, Abadie J, Howard R, Ascencao J, Schechter GP, Kuehl M, Landgren O: Patterns of Monoclonal Immunoglobulins and Serum Free Light Chains Are Significantly Different in African-American Compared to Caucasian MGUS Patients. American Journal of Hematology 86(6): 475-8, Jun 2011.

Weiss BM, Kuehl WM: Advances in understanding monoclonal gammopathy of undetermined significance as a precursor of multiple myeloma. Expert Review Of Hematology 3(2): 165-174, Apr 2010.

Waxman AJ, Mink PJ, Devesa SS, Anderson WF, Weiss BM, Kristinsson SY, McGlynn KA, Landgren O: Racial disparities in incidence and outcome in multiple myeloma: a population-based study. Blood 116(25): 5501-5506, Dec 2010.

Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM: A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 113(22): 5418-5422, May 2009.

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Last updated: 06/13/2015
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