Sigrid C. Veasey, M.D.
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Center for Sleep and Respiratory Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4812
Fax: 215-746-4814
Fax: 215-746-4814
Email:
veasey@mail.med.upenn.edu
veasey@mail.med.upenn.edu
Education:
B.S. (Biochemistry)
Sweet Briar College, 1981.
M.D. (Medicine)
University of Virginia, 1985.
Permanent linkB.S. (Biochemistry)
Sweet Briar College, 1981.
M.D. (Medicine)
University of Virginia, 1985.
Description of Research Expertise
Dr. Veasey’s laboratory focuses on neural injury incurred by hypoxia/reoxygenation events of obstructive sleep apnea. Over the past year her lab identified the specific wake active neuronal populations injured by hypoxia/reoxygenation, the two catecholaminergic groups the noradrenergic locus coeruleus and dopmainergic periacqueductal grey wake neurons. By comparing phenotypes and responses in these vulnerable to resistant wake neuronal populations, her group identified NADPH oxidase as a major contributor to the oxidative injury. Dr. Veasey is now comparing and contrasting these responses with other groups of neurons known to be injured in obstructive sleep apnea. The goal is to find major mechanisms of injury in hippocampal, hypothalamic and cortical neurons and then begin translational studies to identify the optimal overall pharmacotherapeutic approach to prevent or minimize neural injury in sleep apnea.Selected Publications
Kelz, M.B., Sun, Y., Chen, J., Cheng Meng, Q., Moore, J.T., Veasey, S.C., Dixon, S., Thornton, M., Funato, H., Yanagisawa, M.: An essential role for orexins in emergence from general anesthesia. Proceedings of the National Academy of Sciences USA 105(4): 1309-1314, 2008.Zhu, Y., Fenik, P., Zhan, G., Sanfillipo-Cohn, B., Naidoo, N., Veasey, S.C.: Eif-2a protects brainstem motoneurons in a murine model of sleep apnea. Journal of Neuroscience 28(9): 2168-2178, 2008.
Zhu, Y., Fenik, P., Zhan, G., Mazza, E., Kelz, M., Aston-Jones, G., Veasey, S.C.: Selective loss of catecholaminergic wake-active neurons in a murine sleep apnea model. Journal of Neuroscience 27(37): 10060-10071, 2007.
Zhan, G., Fenik, P., Domenico, P., and Veasey, S.C.: Inducible nitric oxide synthase in long-term intermittent hypoxia: hypersomnolence and brain injury. American Journal of Respiratory and Critical Care Medicine 171: 1414-1420, 2005.
*Zhang, B., *Veasey, S.C., Wood, M.A., Leng, L.Z., Kaminski, C., Bruce, J., Leight, S., Joyce, S., Hilburger, K., Schuck, T., Abel, T., Lee, V.M-Y., and Trojanowski, J.Q.: Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. American Journal of Pathology 167: 1361-1369, 2005 Notes: *B. Zhang and S.C. Veasey are co-first authors.
Zhan, G.-X., Serrano, F., Fenik, P., Hsu, R., Kong, L., Pratico, D., Klann, E., and Veasey, S.C.: NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. American Journal of Respiratory and Critical Care Medicine 172: 921-929, 2005 Notes: Featured on cover.
Veasey, S.C., Davis, C.W., Fenik, P., Zhan, G-X., Hsu, Y-J., Pratico, D., Gow, A.J.: Intermittent hypoxia in mice: protracted hypersomnolence and basal forebrain redox injury. Sleep 27: 194-201, 2004.
Fenik, P., Veasey, S.C.: Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. American Journal of Respiratory & Critical Care Medicine 167(4): 563-569, 2003.
Zhan, G-X., Shaheen, F., Mackiewicz, M., Fenik, P., Veasey, S.C.: Serotoninergic receptor subtypes mRNA in hypoglossal motoneurons. Neuroscience 113: 145-154, 2002.
Kapfhamer, D., Valladares, O., Sun, Y., Nolan, P.M., Rux, J.J., Arnold, S.E., Veasey, S.C., Bucan, M.: Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nature Genetics 32(2): 290-295, 2002.