Nirmala Nirinjini Naidoo
Nirmala Nirinjini Naidoo, Ph.D.
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
B.S. (Biochemistry and Microbiology)
University of Durban-Westville, South Africa, 1982.
B.S. (Biochemistry, Honors)
University of Durban-Westville, South Africa, 1984.
University of Durban-Westville, South Africa Dissertation: An Investigation of the Preparation and Interaction of Glycoprotein-DNA Conjugates with Eukaryotic Cell Receptors, 1986.
University of Pennsylvania Dissertation: Structure-Function Studies on Alpha-1-Antichymotrypsin, 1994.
Description of Research ExpertiseDr. Naidoo’s research focuses on the molecular mechanisms of sleep regulation. She uses both the mouse and Drosophila models in her studies using biochemical and proteomic approaches to study the cellular responses to sleep deprivation. She has established that the endoplasmic reticulum is a critical sensor of perturbations that result from sleep deprivation and that a cellular protective pathway, the unfolded protein response, is induced when mice or Drosophila are sleep deprived. In addition, Dr. Naidoo is studying age-related changes in cellular protective pathways in response to sleep deprivation. Recently completed studies suggest that inadequate sleep in the elderly, who normally experience sleep disturbances, leads to an impaired cellular protective response that may in turn lead to further sleep disturbances beginning a vicious cycle of sleep loss and cellular damage. Current studies are exploring the mechanisms by which this may occur. She is also studying the role of the synaptic scaffolding protein, Homer, in sleep-wake behavior.
Selected PublicationsSeibt J, Aton S, Dumoulin M, Coleman T,,Watson A, Naidoo N, Frank MG: Protein synthesis during sleep consolidates cortical plasticity. Current Biology 22: 676-682, 2012.
Naidoo, N, Ferber M, Galante RJ, McShane B, Hu J, Zimmerman J, Maislin, G, Cater J, Worley P, Pack AI: Role of Homer proteins in the maintenance of sleep-wake states. PLoS One 7(4): e35174, 2012.
Naidoo N: The unfolded protein response in mouse cerebral cortex. Methods in Enzymology - UPR and Cell Stress 489: 3-21, 2011.
Naidoo N, Zhu J, Zhu Y, Galante R, Lian J, Veasey S: Endoplasmic reticulum stress in wake active neurons progresses with aging. Aging Cell 10: 640-649, 2011.
Grandner MA, Kripke DF, Naidoo N, Langer RD : Relationships among dietary nutrients and subjective sleep, objective sleep and napping in women. Sleep Medicine 11(2): 180-184, 2010.
McShane BB, Galante RJ, Jensen ST, Naidoo N, Pack AI, Wyner A: Characterization of the bout durations of sleep and wakefulness. Journal of Neuroscience Methods 2010 Notes: [Epub ahead of print]
Nikonova EV, Naidoo N*, Zhang L, Romer M, Cater JR, Scharf MT, Galante RJ, Pack AI* (*co-senior authors): Changes in components of energy regulation in mouse cortex with increases in wakefulness. Sleep 33(7): 889-900, 2010.
Aton SJ, Seibt J, Dumoulin M, Jha SK, Steinmetz N, Coleman T, Naidoo N, Frank MG: Mechanisms of sleep-dependent consolidation of cortical plasticity. Neuron 61(3): 454-466, 2009.
Mackiewicz M, Paigen B, Naidoo N, Pack AI: Analysis of the QTL for sleep homeostasis in mice: Homer1a is a likely candidate. Physiological Genomics 33(1): 91-99, 2008.
Zhu Y, Fenik P, Zhan G, Sanfillipo-Cohn B, Naidoo N, Veasey, SC: eIF-2a protects brainstem montoneurons in a murine model of sleep apnea. Journal of Neuroscience 28(9): 2168-2178, 2008.