faculty photo

Allan I. Pack

John Miclot Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
Post-Graduate Training
Junior House Officer in Medicine, Department of Medicine, Glasgow Royal Infirmary, Scotland [Equivalent to Internship], 1967-1968.
Junior House Officer in Surgery, Glasgow Royal Infirmary, Scotland [Equivalent to Internship; February to July], 1968-1968.
Senior House Officer in Medicine, Department of Medical Cardiology, Glasgow Royal Infirmary, Scotland, 1968-1969.
Registrar in Internal/Pulmonary Medicine, Glasgow Royal Infirmary, Scotland [Equivalent to Residency, Fellowship], 1970-1973.
Wellcome Research Fellow, Centre for Respiratory Investigation, Glasgow Royal Infirmary, Scotland, 1973-1976.
Honorary Senior Registrar, Respiratory Medicine, Centre for Respiratory Investigation, Glasgow Royal Infirmary, Scotland, 1974-1976.
Senior Registrar, Pulmonary Medicine, Glasgow Royal Infirmary (further training in Pulmonary Medicine) [February to August], 1976-1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature. Journal of Applied Physiology (1985) 121(1): 78-88, Jul 2016.

Prasad, B., Usmani, S., Steffen, A.D., Van Dongen, H., Pack, F.M., Strakovsky, I., Staley, B., Dinges, D., Maislin, G., Pack, A.I. and Weaver, T.E.: Short-term variability in apnea-hypopnea index during extended home portable monitoring. Journal of Clinical Sleep Medicine 12(6): 855-863, Jun 2016.

Mullington, J.M., Abbott, .SM., Carroll, J.E., Dijk, D.J., Dinges, D.F., Gehrman, P.R., Ginsburg, G.S., Gozal, D., Haack, M., Lim, D.C., Macrea, M., Pack, A.I., Plante, D.T., Teske, J.A. and Zee, P.C.: Developing biomarker arrays predicting sleep and circadian-coupled risks to health. Sleep 39(4): 727-736, Apr 2016.

Lyons, M.M., Bhatt, N.Y., Kneeland-Szanto, E., Keenan, B.T., Pechar, J., Stearns, B., Elkassabany, N.M., Memtsoudis, S.G., Pack, A.I. and Gurubhagavatula, I.: Sleep apnea in total joint arthroplasty patients and the role for cardiac biomarkers for risk stratification: an exploration of feasibility. Biomarkers in Medicine 10(3): 265-300, 2016.

Malone, S.K., Zemel, B., Compher, C., Souders, M., Chittams, J., Thompson, A.L., Pack, A. and Lipman, T.H.: Social jet lag, chronotype and body mass index in 14-17-year-old adolescents. Chronobiology International 2016 Notes: DOI: 10.1080/07420528.2016.1196697.

Soans, R.E., Lim, D.C., Keenan, B.T., Pack, A.I. and Shackleford, J.A.: Automated protein localization of blood brain barrier vasculature in brightfield IHC images. PLoS One 11(2): e0148411, 2016.

Perron, I.J., Pack, A.I. and Veasey, S.: Diet/energy balance affect wakefulness independent of body weight. Sleep 38(12): 1893-1903, Dec 2015.

Bjornsdottir, E., Keenan, B.T., Eysteinsdottir, B., Arnardottir, E.S., Janson, C., Gislason, T., Sigurdsson, J.F., Kuna, S.T., Pack, A.I. and Benediktsdottir, B.: Quality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure. Journal of Sleep Research 24(3): 328-338, Jun 2015.

Li, Q.Y., Berry, R.B., Goetting, M.G., Staley, B., Soto-Calderon, H., Tsai, S.C., Jasko, J.G., Pack, A.I. and Kuna, S.T.: Detection of upper airway status and respiratory events by a current generation positive airway pressure device. Sleep 38(4): 597-605, Apr 2015.

Pak, V.M., Keenan, B.T., Jackson, N., Grandner, M.A., Maislin, G., Teff, K., Schwab, R.J., Arnardottir, E.S., Juliusson, S., Benediktsdottir, B., Gislason, T. and Pack, A.I.: Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. International Journal of Obesity (London) 39(3): 472-479, 2015.

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Last updated: 08/11/2016
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