Untitled Document

Itzhak Nissim

Research Professor of Pediatrics

Department: Pediatrics

Contact information

CHOP
34th & CIVIC CENTER
4399
Philadelphia, PA 19104

Education:
B.Sc. (Life Science)
Bar Ilan University, Ramat Gan, Israel , 1972.
M.Sc. (Life Science)
Hebrew University, Jerusalem, Israel, 1974.
Ph.D. (Life Science)
Weizmann Institute of Science, Rehovot, Israel, 1979.

Post-Graduate Training
Department of Biochemistry, Bar Ilan Unviersity, Ramat Gan, Israel, 1969-1971.
Department of Food Technology, Institute of Agriculture, Bet Dagan, Israel, 1971-1973.
Department of Anatomy and Physiology, Hebrew University, Rehovot, Israel, 1973-1975.
Department of Isotope Research, Weizmann Institute of Science, Rehovot, Israel, 1975-1979.
Research Fellow, CHOP; University of Pennsylvania School of Medicine, 1979-1981.

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Selected Publications

Kasumov T., Comte B, Puchowicz M. A., Brunengraber L., Jobbins K., Thomas K., Puchowicz MA, David F., Kinman P., Wherli S., Dahms W., Kerr D., Nissim I., Brunengraber H.: New secondary metabolites of phenylbutyrate in humans and rat. Drug Met. & Disposition 32: 1-10, 2004.

Welbourne T, and Nissim I: Acidosis and amino acid metabolism Metabolic & Therapeutic Aspect of Amino Acids in Clinical Nutrition, 2nd edition. Luc A (eds.). CRC Press, Page: 375-388, 2004.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Nissim I: Metabolism of brain amino acids following pentylenetetrazole treatment. Epilepsy Res 53(1-2): 151-162, 2003.

Welbourne TC, Friday E, Fowler R, Turturro F, Nissim I: Troglitazone acts by PPAR{gamma} and PPAR{gamma}-independent pathways on LLC-PK1-F+ acid-base metabolism. Am J Physiol Renal Physiol September 2003 Notes: Epub ahead of print.

Nissim I, Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M.: Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N. Biochem J 376: 179-188, 2003.

Comte B, Kasumov T, Pierce BA, Puchowicz MA, Scott ME, Dahms W, Kerr D, Nissim I, Brunengraber H.: Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans. J Mass Spectrom 37(6): 581-590, 2002.

Brosnan JT, Brosnan ME, Nissim I: Application of 15N to the study of hepatic nitrogen metabolism. Adv Enzyme Regul 42: 305-315, 2002.

Coates G, Nissim I, Battarbee H, Welbourne T: Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells. Am J Physiol Endocrinol Metab 283(4): E729-E737, 2002.

Nissim I, Horyn O, Daikhin Y, Nissim I, Lazarow A, Yudkoff M: Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N. Am J Physiol Endocrinol Metab 283(6): E1123-E1134, 2002.

Feldkamp T, Kribben A, Nissim I, Weinberg J.M, M.A. Venkatschalam: Dependence of proximal tubule (PT) energetics on mitochondrial complex I and its relation to energetic failure after hypoxia/reoxygenation (H/R). J AM SOC NEPHROL 13(Suppl. S): 321A, September 2002.