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Robert Gordon Kalb

Professor of Neurology
Department: Neurology
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Abramson Research Center #814
3615 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215 590 0691
Fax: 267 426 5165
B.A. (Biology)
Wesleyan University , 1978.
MD (Medicine)
Cornell University Medical College, 1982.
Post-Graduate Training
Intern in Medicine, Montefiore Hospital, Bronx, NY, 1982-1983.
Resident in Medicine, Montefiore Hospital, Bronx, NY, 1983-1984.
Resident in Neurology, Yale-New Haven Hospital, 1984-1987.
Postdoctoral Fellow, Department of Neurobiology, Yale University, New Haven, CT, 1987-1990.
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Description of Clinical Expertise

I am a Board Certified Adult Neurologist who has been in active and continuous practice since 1987. I have facility in the treatment of a broad range of Neurological Disorders. I have special expertise in the diagnosis and management of ALS patients.

Description of Research Expertise

My research areas of expertise related to neuro-degenerative diseases and nervous system development.

In the diseases arena, I have particular proficiency in the molecular and cellular underpinning of adult-onset neurodegenerative pathophysiology. there is an emerging interest in the role of intermediary metabolism and aging in relation to neurodegenerative diseases and I am specifically adept in these processes.

In the development arena, I have expertise in the cellular and molecular basis of activity-dependent development. In addition, spinal cord development is a special strong suit of mine.

In both arenas, I have a comprehensive and up-to-date understanding of how the fields have developed and the most current research.

Selected Publications

Flibotte, J.J., Jablonski, A.M. and Kalb R.G.: Oxygen sensing neurons and neuropeptides regulate survival after abnoxia in developng C. elegans. PloS One 9, 2014.

Kalb, R.G.: ICU-acquired weakness and recovery from critical illness. New England Journal of Medicine 371: 287, 2014.

Lim, M.A., Bence, K.K, Sandesara, I., Andreux, P., Auwerx, J., Ishibashi, J., Seale,P. and Kalb, R.G.: Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis. Human Molecular Genetics doi:10:1093/hmg/ddu214, 2014.

Jablonski,A. M. and Kalb, R.G.: GluA1 promotes the activity-dependent development of motor circuitry in the developing segmental spinal cord. [Review] Annals of the New York Academy of Sciences 1279: 54-59, 2013.

Lim, M., Selak, M., Xiang, Z., Krainc, D., Neve, R., Kraemer, B., Watts, J. and Kalb, R. : Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease Journal of Neuroscience 32: 1123-1141, 2012.

Couthouis, J., Hart, M., Erion, R., King, O., Diaz, Z., Nakaya, T., Ibrahim, F., Kim, H., Mojsilovic-Petrovic, J., Panossian, S., Kim, S., Frackelton, E., Solski, J., Williams, J., Clay-Falcone, D., Elman, L., McCluskey, L., Greene, R., Hakonarson, H., Kalb, R., Lee, V., Trojanowski, J., Nicholson, G., Blair, I., Bonini, N., Van Deerlin, V., Mourelatos, Z., Shorter, J., and Gitler, S. : Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics 21: 2899-2911, 2012.

Moronetti, L., Dersh, D., Boccitto, M. , Kalb, R,G., and Lamitina, T. : Stress and aging induce distinct polyQ protein aggregation states Proc Natl Acad Sci USA, 109: 10587-92, 2012.

Boccitto, M, Lamitina, T and Kalb, R: Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans. PloS One 7: e33494, 2012.

Couthouis J., M.P. Hart, J. Shorter, M. DeJesus-Hernandez, R. Erion, R.E. Oristano, X.A. Liu, D. Ramos, N. Jethava, D. Hosangadi, J. Epstein, A. Chiang, Z. Diaz, T. Nakaya, F. Ibrahim, H.J. Kim, J.A. Solski, K.L. Williams, J. Mojsilovic-Petrovic, C. Ingre, K. Boylan, N. Graff-Radford, D. Dickson, D. Clay-Falcone, L. Elman, L. McCluskey, R. Greene, R.G. Kalb, V.M. Lee, J.Q. Trojanowski, A.C. Ludolph, W.Robberecht, P.M. Andersen, G.A. Nicholson, I.P. Blair, O.D. King, N.M. Bonini, V.M. Van Deerlin, R. Rademakers, Z. Mourelatos, A.D. Gitler: : A yeast functional screen predicts new candidate ALS disease genes Proc Natl Acad Sci USA 108: 20881-20890, 2011.

Goo-Bo Jeong, Jelena Mojsilovic-Petrovic, Marco Boccitto, and Robert Kalb: Signaling events in axons and/or dendrites render motor neurons vulnerable to mutant superoxide dismutase toxicity. Journal of Neuroscience 31: 295-299, 2011.

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Last updated: 04/08/2016
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