Untitled Document

Diva D. De Leon Crutchlow

Assistant Professor of Pediatrics at the Children's Hospital of Philadelphia

Department: Pediatrics

Contact information

Division of Endocrinology/Diabetes
The Children's Hospital of Philadelphia
3615 Civic Center Blvd
Abramson Research Center, Room 802A
Philadelphia, PA 19104

Office: 267-426-5529
Fax: 215-590-1605

Email:
DELEON@EMAIL.CHOP.EDU

Education:
M.D.
University of Panama, 1992.

Links
The Joseph Stokes Jr. Research Institute member profile

Post-Graduate Training
Rotating Internship, Complejo Hospitalario, Panama, Republic of Panama, 1992-1993.
Rotating Internship, Sistema Integrado de Salud de Azuero; Los Santos; Republic of Panama, 1993-1994.
Pediatric Residency, Monmouth Medical Center, Long Branch, NJ, 1996-1999.
Pediatric Endocrinology Fellowship, The Children's Hospital of Philadelphia, 1999-2002.
Postdoctoral Fellow (NRSA fellowship training in Medicine-Diabetes/Endocrine), University of Pennsylvania, 2000-2001.
Postdoctoral Fellow (LWPES-Eli Lilly fellowship), University of Pennsylvania, 2001-2002.
Postdoctoral Fellow (Individual NRSA fellowship training), University of Pennsylvania, 2002-2003.

Permanent link

Description of Research Expertise

Diva D. De León, M.D. is an Assistant Professor of Pediatrics and a Pediatric Endocrinologist in the Division of Endocrinology and Diabetes at The Children's Hospital of Philadelphia. Dr. De León research interest focuses on congenital and acquired forms of hyperinsulinemic hypoglycemia. She is particularly interested in the role that alterations of the entero-insular axis may play in the pathophysiology of these disorders.

Description of Clinical Expertise

Dr. De León specializes in the diagnosis and management of monogenic disorders of insulin regulation resulting in diabetes and hypoglycemia, and general endocrinologic problems. Dr. De León predominantly cares for children with congenital and acquired forms of hyperinsulinemic hypoglycemia.

Selected Publications

Calabria AC, Gallagher PR, Simmons R, Blinman T, De León DD.: Postoperative Surveillance and Detection of Postprandial Hypoglycemia after Fundoplasty in Children. J Pediatr 159(4): 597-601, October 2011.

Pinney SE, Oliver-Krasinski J, Ernst L, Hughes N, Patel P, Stoffers DA, Russo P, De León DD.: Neonatal Diabetes and Congenital Malabsorptive Diarrhea Attributable to a Novel Mutation in the Human Neurogenin-3 Gene Coding Sequence. J Clin Endocrinol Metab 96(7): 1960-5, July 2011.

Soleimanpour S.A., Crutchlow M.F., Ferrari A.M., Raum J.C., Groff D.N., Rankin M.M., Liu C., De Leon D.D., Naji A., Kushner J.A., and Stoffers D.A. : Calcineurin signaling regulates human islet β-cell survival J Biol Chem October 2010.

Weaver LA, De León DD, Borgmann-Winter K.: : Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder. J Child and Adolesc Psychopharmacol 20(2): 153-7, Apr 2010.

Palladino AA, Sayed S, Katz LE, Gallagher PR, De León DD.: Increased glucagon-like peptide-1 secretion and post-prandial hypoglycemia in children after Nissen fundoplication. J Clin Endocrinol Metab 94(1): 39-44, Jan 2009.

De Leon DD, Li C, Delson MI, Matschinsky FM, Stanley CA, Stoffers DA.: Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion. Journal of Biological Chemistry 283(38): 25786-93, Sep 19 2008.

Hoffman TL, Blanco E, Lane A, Galvin-Parton P, Gadi I, Santer R, De León D, Stanley C, Wilson TA. : Glucose metabolism and insulin secretion in a patient with ABCC8 mutation and Fanconi-Bickel syndrome caused by maternal isodisomy of chromosome 3. Clin Genet 71(6): 551-7, June 2007.

Masia R, De León DD, MacMullen C, McKnight H, Stanley CA, Nichols CG: A mutations in the TMD0-L0 region of SUR1 (L225P) causes permanent neonatal diabetes mellitus (PNFM). Diabetes 56(5): 1357-62, May 2007.

Desai B, Oliver-Krasinski J, De León DD, Farzad C, Hong N, Leach SD, Stoffers DA. : Preexisting acinar cells contribute to acinar, but not β cell, regeneration. The Journal of Clinical Investigation 117(4): 971-7, April 2007.

Lee CS*, De León DD*, Kaestner KH, Stoffers DA. These authors contributed equally to this work: Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes 55((2)): 269-72, Feb 2006.