Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Wenchao Song, Ph.D.

Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations

Contact information
Department of Pharmacology
1254 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 573-6641
Fax: (215) 746-8941
Education:
B.Sc. (Biology)
Ocean University of China, Qingdao, P.R. China, 1983.
(Certificate in English)
Shanghai Foreign Language Institute, Shanghai, P.R. China, 1984.
Ph.D. (Biochemistry)
School of Biological Sciences, University of Wales, U.K, 1989.
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Description of CVI Expertise

CVI Program Unit(s):
Lipid / Atherosclerosis / CAD / ACS / Prevention
Thrombosis / Hemostasis

CVI Research Description:
Dr. Song is interested in the vascular biology of inflammatory mediators, including complement, TLRs and macrophage biology. His lab has created and used transgenic and knockout mice to study the role of innate immunity in vascular injury and thrombotic disorders.

Selected Publications

Dunkelberger, J.R. and Song, W.-C.: Complement and its role in innate and adaptive immune responses Cell Res. 20: 34-50, 2010.

Kimura, Y., Zhou, L., Miwa, T. and Song, W.-C. : Genetic and therapeutic targeting of properdin prevents complement-mediated tissue injury. J. Clin Invest. 120(10): 3545-3554, 2010.

Fang, C., Miwa, T. and Song, W.-C. : Decay-accelerating factor regulates T cell immunity in the context of inflammation by influencing co-stimulatory molecule expression on antigen-presenting cells. Blood. 118(4): 1008-1014, 2011.

Dunkelberger, J., Zhou, L., Miwa, T. and Song, W.-C. : C5aR expression in a novel GFP reporter gene knock-in mouse: implications for the mechanism of action of C5aR signaling in T cell immunity. J. Immunol 188(8): 4032-4042, 2012.

Miwa, T., Zhou, L., Maldonado, M. A., Eisenberg, R. A. and Song, W.-C. : Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice. J. Immunol 189(11): 5434-5441, 2012.

Lesher, A. M., Zhou, L., Kimura, Y., Sato,S., Gullipalli, D., Ruseva, M. M., Pickering, M.C., Herbert, A. P., Barlow, P., Skerka, C., Zipfel, P., Miwa, T., Tung, K. S. and Song, W.-C.: Lethal C3 glomerulonephritis resembling human dense deposit disease caused by combined fH C-terminal mutation and properdin deficiency in mice. J. Am. Soc. Nephrol. 24(1): 53-65, 2013.

Ruseva, M. M., Vernon, K. A., Lesher, A. M., Schwaeble, W. J., Ali, Y. M., Botto, M., Cook, H. T., Song, W.-C., Stover, C. and Pickering, M. C. : Properdin deficiency exacerbates C3 glomerulopathy in factor H-deficient mice. J. Am. Soc. Nephrol. 24(1): 43-52, 2013.

Barata, L., Miwa, T., Sato, S., Kim, D. D., Mohammed, I. and Song, W.-C. : Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases fH-dependent resistance of peripheral platelets to complement attack. J. Immunol 190(6): 2886-2895, 2013.

Miwa, T., Sato, S., Gullipalli, D., Nangaku, M and Song, W.-C. : Blocking properdin, the alternative pathway complement and anaphylatoxin receptors ameliorates renal ischemia reperfusion injury in decay-accelerating factor and CD59 double knockout mice. J. Immunol 190(7): 3552-3559, 2013.

Lesher, A. M., Nilsson, B. and Song, W.-C.: Properdin in Complement Activation and Tissue Injury. Mol Immunol. [Epub ahead of print], June 2013.

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Last updated: 07/15/2013
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