Wenchao Song, Ph.D.
Professor of Pharmacology
Department: Pharmacology
Graduate Group Affiliations
Contact information
Institute for Translational Medicine and Therapeutics
1254 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
1254 BRB II/III
421 Curie Boulevard
Philadelphia, PA 19104-6160
Office: (215) 573-6641
Fax: (215) 746-8941
Fax: (215) 746-8941
Email:
songwe@upenn.edu
songwe@upenn.edu
Publications
Links
Search PubMed for articles
Faculty Page, Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine
Faculty Page, Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Page, Department of Pharmacology, University of Pennsylvania School of Medicine
Search PubMed for articles
Faculty Page, Graduate Group in Pharmacological Sciences, University of Pennsylvania School of Medicine
Faculty Page, Cardiovascular Institute, University of Pennsylvania School of Medicine
Faculty Page, Department of Pharmacology, University of Pennsylvania School of Medicine
Education:
B.Sc. (Biology)
Ocean University of China, Qingdao, P.R. China, 1983.
(Certificate in English)
Shanghai Foreign Language Institute, Shanghai, P.R. China, 1984.
Ph.D. (Biochemistry)
School of Biological Sciences, University of Wales, U.K, 1989.
Permanent linkB.Sc. (Biology)
Ocean University of China, Qingdao, P.R. China, 1983.
(Certificate in English)
Shanghai Foreign Language Institute, Shanghai, P.R. China, 1984.
Ph.D. (Biochemistry)
School of Biological Sciences, University of Wales, U.K, 1989.
Description of CVI Expertise
CVI Program Unit(s):Lipid / Atherosclerosis / CAD / ACS / Prevention
Thrombosis / Hemostasis
CVI Research Description:
Dr. Song is interested in the vascular biology of inflammatory mediators, including complement, TLRs and macrophage biology. His lab has created and used transgenic and knockout mice to study the role of innate immunity in vascular injury and thrombotic disorders.
Selected Publications
Fang C, Zhang X, Miwa T, Song W-C : Complement activation promotes the development of inflammatory Th-17 cells through interaction with TLR4 signaling. Blood 2009 [Epub ahead of print]Bao L, Haas M, Pippin J, Wang Y, Miwa T, Chang A, Minto AW, Petkova M, Qiao G, Song W-C, Alpers CE, Zhang J, Shankland SJ, Quigg RJ: Focal and segmental glomerulonephritis induced in mice lacking decay-accelerating factor on T cells. J Clin Invest 119: 1264-1274, 2009.
An G, Miwa T, Song W-L, Lawson JA, Rader DJ, Zhang Y, Song W-C: CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol 46: 1702-1709, 2009.
Miwa T, Zhou L, Kimura K, Kim DD, Bandoola A, Song, W-C: Complement-dependent T cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood 113: 2684-2694, 2009.
Khor VK, Tong MH, Qian Y, Song W-C: Gender-specific expression and mechanism of regulation of estrogen sulfotransferase in adipose tissues of the mouse. Endocrinology 149: 5440-5448, 2008.
Kim DD, Miwa T, Kimura T, Schwendener RA, van Lookeren Campagne M, Song W-C: Deficiency of DAF and Crry on murine platelets leads to complement-dependent clearance via the macrophage phagocytic receptor CRIg. Blood 112: 1109-1119, 2008.
Gong H, Jarzynka MJ, Cole TJ, Wada T, Lee JH, Song W-C, DeFranco DB, Cheng S, Xie W: Glucocorticoids antagonize estrogens by glucocorticoid receptor-mediated activation of estrogen sulfotransferase. Cancer Res 68: 7386-7393, 2008.
Kimura Y, Miwa T, Zhou L, Song W-C: Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement. Blood 111: 732-740, 2008.
Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, Lambris JD, Wetsel RA, Miwa T, Song WC: Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110: 228-236, 2007.
Miwa T, Maldonado MA, Zhou L, Yamada K, Gilkeson GS, Eisenberg RA, Song WC: Decay-accelerating factor ameliorates systemic autoimmune disease in MRL/lpr mice via both complement-dependent and -independent mechanisms. Am J Pathol 170: 1258-1266, 2007.