Penn Cardiovascular Institute

Penn Cardiovascular Institute Research Directory

faculty photo

Warren S. Pear, M.D., Ph.D.

Gaylord P. and Mary Louise Harnwell Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
556 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: (215) 573-7764
Fax: (215) 573-6725
Education:
B.A. (Economics)
Williams College, Williamstown, MA, 1980.
Ph.D. (Tumor Biology - George Klein)
Karolinska Institute, Stockholm, Sweden, 1987.
M.D.
University of Rochester, Rochester, NY, 1989.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Myocyte Biology / Heart Failure

CVI Research Description:
Notch signaling in cardiovascular development and homeostasis.

Selected Publications

Liu H, Chi WS, Chiang MY, Arnett KL, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS: Notch dimerization is required for leukemogenesis and T cell development. Genes Dev. 24: 2395-2407, 2010.

Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC, Pear WS: Differential ability of Tribbles family members to promote degradation of C/EBP{alpha} and induce acute myelogenous leukemia. Blood 116: 1321-8, 2010.

Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS: Pre-TCR signaling inactivates Notch1transcription by antagonizing E2A. Genes Dev. 23: 1665-76, 2009.

Chiang MY, Xu L, Shestova O, Histen G, L’Heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS: Leukemia-associated Notch1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest. 118: 3181-94, 2008.

Maillard I, Koch U, Dumortier A, Shestova O, Xu L, Sai H, Pross SE, Aster JC, Bhandoola A, Radtke F, Pear WS: Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2: 356-66, 2008.

Aster JC, Pear WS, Blacklow SC: Notch signaling in leukemia. Annu Rev Pathol. 3: 587-613, 2008.

Fang TC, Ohtani Y, Del Bianco C, Knoblock D, Blacklow SC, Pear WS: Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27: 100-10, 2007.

Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez C, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS: Tribbles homologue 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10: 401-11, 2006.

Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC: c-Myc is an important direct target of Notch1 in T cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20: 2096-109, 2006.

back to top
Last updated: 08/26/2014
The Trustees of the University of Pennsylvania