Warren S. Pear, M.D., Ph.D.
Gaylord P. and Mary Louise Harnwell Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
611 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104-6160
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: (215) 573-7764
Fax: (215) 573-6725
Fax: (215) 573-6725
Email:
wpear@mail.med.upenn.edu
wpear@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Training Program in Immunobiology of Normal and Neoplastic Lymphocytes
Cell and Molecular Biology Graduate Group
Immunology Graduate Group
Abramson Family Cancer Research Institute
Search PubMed for articles
Training Program in Immunobiology of Normal and Neoplastic Lymphocytes
Cell and Molecular Biology Graduate Group
Immunology Graduate Group
Abramson Family Cancer Research Institute
Education:
B.A. (Economics)
Williams College, Williamstown, MA, 1980.
Ph.D. (Tumor Biology - George Klein)
Karolinska Institute, Stockholm, Sweden, 1987.
M.D.
University of Rochester, Rochester, NY, 1989.
Permanent linkB.A. (Economics)
Williams College, Williamstown, MA, 1980.
Ph.D. (Tumor Biology - George Klein)
Karolinska Institute, Stockholm, Sweden, 1987.
M.D.
University of Rochester, Rochester, NY, 1989.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
Myocyte Biology / Heart Failure
CVI Research Description:
Notch signaling in cardiovascular development and homeostasis.
Selected Publications
Liu H., Chi W.S., Chiang M.Y., Arnett K.L., Xu L., Shestova O., Wang H., Li Y.M., Bhandoola A., Aster J.C., Blacklow S.C., Pear W.S.: Notch dimerization is required for leukemogenesis and T cell development. Genes Dev. 24: 2395-2407, 2010.Dedhia P.H., Keeshan K., Uljon S., Xu L., Vega M.E., Shestova O., Zaks-Zilberman M., Romany C., Blacklow S.C., Pear W.S.: Differential ability of Tribbles family members to promote degradation of C/EBP{alpha} and induce acute myelogenous leukemia. Blood 116: 1321-8, 2010.
Yashiro-Ohtani Y., He Y., Ohtani T., Jones M.E., Shestova O., Xu L., Fang T.C., Chiang M.Y., Intlekofer A.M., Blacklow S.C., Zhuang Y., Pear W.S.: Pre-TCR signaling inactivates Notch1transcription by antagonizing E2A. Genes Dev. 23: 1665-76, 2009.
Chiang M.Y., Xu L., Shestova O., Histen G., L’Heureux S., Romany C., Childs M.E., Gimotty P.A., Aster J.C., Pear W.S.: Leukemia-associated Notch1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. J Clin Invest. 118: 3181-94, 2008.
Maillard I., Koch U., Dumortier A., Shestova O., Xu L., Sai H., Pross S.E., Aster J.C., Bhandoola A., Radtke F., Pear W.S.: Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2: 356-66, 2008.
Aster J.C., Pear W.S., Blacklow S.C.: Notch signaling in leukemia. Annu Rev Pathol. 3: 587-613, 2008.
Fang T.C., Ohtani Y., Del Bianco C., Knoblock D., Blacklow S.C., Pear W.S.: Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27: 100-10, 2007.
Keeshan K., He Y., Wouters B.J., Shestova O., Xu L., Sai H., Rodriguez C., Maillard I., Tobias J.W., Valk P., Carroll M., Aster J.C., Delwel R., Pear W.S.: Tribbles homologue 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10: 401-11, 2006.
Weng A.P., Millholland J.M., Yashiro-Ohtani Y., Arcangeli M.L., Lau A., Wai C., del Bianco C., Rodriguez C.G., Sai H., Tobias J., Li Y., Wolfe M.S., Shachaf C., Felsher D., Blacklow S.C., Pear W.S.*, Aster J.C.*: c-Myc is an important direct target of Notch1 in T cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20: 2096-109, 2006 Notes: *corresponding authors.