Warren S. Pear, M.D., Ph.D.
Gaylord P. and Mary Louise Harnwell Associate Professor
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations
Contact information
611 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104-6160
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: (215) 573-7764
Fax: (215) 573-6725
Fax: (215) 573-6725
Email:
wpear@mail.med.upenn.edu
wpear@mail.med.upenn.edu
Publications
Links
Search PubMed for articles
Abramson Family Cancer Research Institute
Cell and Molecular Biology Graduate Group
Immunology Graduate Group
Search PubMed for articles
Abramson Family Cancer Research Institute
Cell and Molecular Biology Graduate Group
Immunology Graduate Group
Education:
B.A. (Economics)
Williams College, Williamstown, MA, 1980.
Ph.D. (Tumor Biology - George Klein)
Karolinska Institute, Stockholm, Sweden, 1987.
M.D.
University of Rochester, Rochester, NY, 1989.
Permanent linkB.A. (Economics)
Williams College, Williamstown, MA, 1980.
Ph.D. (Tumor Biology - George Klein)
Karolinska Institute, Stockholm, Sweden, 1987.
M.D.
University of Rochester, Rochester, NY, 1989.
Description of CVI Expertise
CVI Program Unit(s):Cardiovascular Development / Congenital Heart Disease
Myocyte Biology / Heart Failure
CVI Research Description:
Notch signaling in cardiovascular development and homeostasis.
Selected Publications
Weng, A.P., Millholland, J.M., Yashiro-Ohtani, Y., Arcangeli, M.L., Lau, A., Wai, C., del Bianco, C., Rodriguez, C.G., Sai, H., Tobias, J., Li, Y., Wolfe, M.S., Shachaf, C., Felsher, D., Blacklow, S.C., Pear, W.S.*, Aster, J.C.*: c-Myc is an important direct target of Notch1 in T cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20: 2096-2109, 2006 Notes: *corresponding authors.Keeshan, K., He, Y., Wouters, B.J., Shestova, O., Xu, L., Sai, H., Rodriguez, C., Maillard, I., Tobias, J.W., Valk, P., Carroll, M., Aster, J.C. Delwel, R., and Pear, W.S.: Tribbles homologue 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10: 401-411, 2006.
Fang, T.C., Ohtani, Y., Del Bianco, C., Knoblock, D., Blacklow, S.C., Pear, W.S.: Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity 27: 100-110, 2007.
Maillard, I., Koch, U., Dumortier, A., Shestova, O., Xu, L., Sai, H., Pross, S.E., Aster, J.C., Bhandoola, A., Radtke, F., Pear, W.S.: Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell 2: 356-366, 2008.
Chiang, M.Y., Xu, L., Shestova, O., Histen, G., L’Heureux, S., Romany, C., Childs, M.E., Gimotty, P.A., Aster, J.C., and Pear, W.S.: Leukemia-associated Notch1 alleles are weak tumor initiators, but impose Notch “addiction” on K-ras initiated leukemia. J. Clin. Invest. 118: 3181-3194, 2008.
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