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Warren S. Pear, M.D., Ph.D.

Gaylord P. and Mary Louise Harnwell Professor
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
556 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104-6160
Office: (215) 573-7764
Fax: (215) 573-6725
Education:
B.A. (Economics)
Williams College, Williamstown, MA, 1980.
Ph.D. (Tumor Biology - George Klein)
Karolinska Institute, Stockholm, Sweden, 1987.
M.D.
University of Rochester, Rochester, NY, 1989.
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Description of CVI Expertise

CVI Program Unit(s):
Cardiovascular Development / Congenital Heart Disease
Myocyte Biology / Heart Failure

CVI Research Description:
Notch signaling in cardiovascular development and homeostasis.

Selected Publications

Russell JHR, Petrovic J, Rausch DM, Zhou Y., Lareau C, Kluk, MJ, Christie AL, Lee L, Tarjan D, Guo B, Donohue LKH, Gillespie S, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, and Pear WS: A Unique B-cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B-cell Lymphomas. Cell Reports 2017 Notes: Accepted for publication (September 2017).

Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Liu XS, Blacklow SC, Aster JC: Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Science signaling 10(477), May 2017 Notes: No page number issued.

Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, His TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, Wang A, Supapannachart RJ, Lee HL, Lim CH, Nace A, Guo A, Treffeisen E, Andl T, Ramirez RN, Murad R, Offermanns S, Metzger D, Chambon P, Widgerow AD, Tuan TL, Mortazavi A, Gupta RK, Hamilton BA, Millar SE, Seale P, Pear WS, Lazar MA, Cotsarelis G: Regeneration of fat cells from myofibroblasts during wound healing. Science 355(6326): 748-752, Feb 2017.

Aster JC, Pear WS, Blacklow SC: The Varied Roles of Notch in Cancer. Annual review of pathology 12: 245-275, Jan 2017.

Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Rajeswaran M, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S and Pear WS: MafB is a novel enhancer of oncogenic Notch signaling in T-cell acute lymphoblastic leukemia. Science Signaling 2017 Notes: Accepted for publication (September 2017).

Kobayashi M, Nabinger S, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, Kaplan MH, Lacorazza HD, Zhang ZY, Liu Y: Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals In Early T Cell Progenitors. Stem cells 35(4): 1053-1064, Dec 2016.

Chiang MY, Wang Q, Gormley AC, Stein SJ, Xu L, Shestova O, Aster JC, Pear WS: High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia. Blood 128(18): 2229-2240, Nov 2016.

Greene M, Lai Y, Pajcini KV, Bailis W, Pear WS, Lancaster E: Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand. PloS one 11(9): e0161157, Sept 2016.

Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC: Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure 24(5): 687-96, May 2016.

Stein SJ, Mack EA, Rome KS, Pajcini KV, Ohtani T, Xu L, Li Y, Meijerink JPP, Faryabi RB, Pear WS: Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. PloS one 11(5): e0155408, May 2016.

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Last updated: 09/18/2017
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