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Lynch Lab Publications:
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Ray D, Kazan H, Cook KB, Weirauch MT, Najafabadi HS, Li X, Gueroussov S, Albu M, Zheng H, Yang A, Na H, Irimia M, Matzat LH, Dale RK, Smith SA, Yarosh CA, Kelly SM, Nabet B, Mecenas D, Li W, Laishram RS, Qiao M, Lipshitz HD, Piano F, Corbett AH, Carstens RP, Frey BJ, Anderson RA, Lynch KW, Penalva LO, Lei EP, Fraser AG, Blencowe BJ, Morris QD, Hughes TR. (2013) A compendium of RNA-binding motifs for decoding gene regulation. Nature 499(7457):172-7.

Shankarling G, Lynch KW. (2013) Minimal functional domains of paralogues hnRNP L and hnRNP LL exhibit mechanistic differences in exonic splicing repression. Biochem J. 453(2):271-9.
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Martinez NM, Lynch KW. (2013) Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn. Immunol Rev. 253(1):216-36.
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Vu NT, Park MA, Shultz JC, Goehe RW, Hoeferlin LA, Shultz MD, Smith SA, Lynch KW, Chalfant CE. (2013) hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L. J Biol Chem. 288(12):8575-84.
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Chiou NT, Shankarling G, Lynch KW. (2013) hnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly. Mol Cell. 49(5):972-82.
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Martinez NM, Pan Q, Cole BS, Yarosh CA, Babcock GA, Heyd F, Zhu W, Ajith S, Blencowe BJ, Lynch KW. (2012) Alternative splicing networks regulated by signaling in human T cells. RNA. 18(5):1029-40.
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Heyd F, Lynch KW. (2011) DEGRADE, MOVE, REGROUP: signaling control of splicing proteins. Trends Biochem Sci. 36(8):397-404.
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Motta-Mena LB, Smith SA, Mallory MJ, Jackson J, Wang J, Lynch KW. (2011) A disease-associated polymorphism alters splicing of the human CD45 phosphatase gene by disrupting combinatorial repression by heterogeneous nuclear ribonucleoproteins (hnRNPs). J Biol Chem. 286(22):20043-53.
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Mallory MJ, Jackson J, Weber B, Chi A, Heyd F, Lynch KW. (2011) Signal- and development-dependent alternative splicing of LEF1 in T cells is controlled by CELF2. Mol Cell Biol. 31(11):2184-95.
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Shankarling G., Lynch K.W. (2010) Living or dying by RNA processing: caspase expression in NSCLC. J Clin Invest. 120(11):3798-801.
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Heyd F., Lynch K.W. (2010) Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing. Mol Cell. 40(1):126-37.
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Motta-Mena L., Heyd F., and K.W. Lynch (2010) Context-dependent regulatory mechanism of the splicing factor hnRNP L. Mol Cell. 37(2):223-34.
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Heyd F, Lynch K.W. (2009) Getting under the skin of alternative splicing: identification of epithelial-specific splicing factors. Mol Cell. 33(6):674-6.
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Topp, J.D., Jackson, J, Melton, A.A. and K.W. Lynch (2008) A cell-based screen for splicing regulators identifies hnRNP LL as an additional signal-induced repressor of CD45 variable exon 4. RNA 14: 2038-2049.
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House, A.E. and K.W. Lynch (2008) Regulation of Alternative Splicing: More than just the ABCs. J. Biol. Chem. 283: 1217-21.
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Melton, A.A., Jackson, J.M., Wang, J. and K.W. Lynch (2007) Combinatorial control of signal-induced exon repression by HnRNP L and PSF. Mol. Cell. Biol. 27, 6972-6984.
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Lynch, K.W. (2007) Regulation of alternative splicing by signal transduction pathways. In Alternative Splicing in the Postgenomic Era edited by B. Blencowe and B. Graveley. Eurekah Biosciences Press and Lander Press. Adv Exp Med Biol. 623:161-74.
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Ip, J., A. Tong, Q. Pan, J. Topp, B.J. Blencowe* and K.W. Lynch. (2007) Global analysis of alternative splicing during T cell activation. RNA 13:563-572. (* co-corresponding authors)
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Lynch K.W. (2006) Cotranscriptional splicing regulation: it's not just about speed. Nat Struct Mol Biol 13(11):952-3.
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House, A.E. and K.W. Lynch. (2006) An exonic splicing silencer represses spliceosome assembly after ATP-dependent exon recognition. Nat. Struct. Mol. Biol., 13:937-944.
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Johnson, E.B., D.J. Steffen, K.W. Lynch, and J. Herz. (2006) Defective splicing of MEGF7/LRP4, a regulator of distal limb development, in autosomal recessive Mulefoot disease. Genomics 88: 600-609.
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Levinson, N., R. Hinman, A. Patil, C.R.J. Stephenson, S. Werner, G.H.C. Woo, J. Xiao, P. Wipf and K.W. Lynch (2006) Use of transcriptional synergy to augment sensitivity of a splicing reporter assay. RNA 12: 925-930.
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Tong, A., J. Nguyen and K.W. Lynch (2005) Differential expression of CF45 isoforms is controlled by the combined activity of basal and inducible splicing regulatory elements in each of the variable exons. J. Biol. Chem. 280:38297-304.
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Rothrock, C.R.*, A.E. House*, and K.W. Lynch (2005) HnRNP L represses exon splicing via a regulated exonic splicing silencer. EMBO J 24: 2792-2802. (* co-first authors)
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Lynch, K.W. (2004) Consequences of regulated pre-mRNA splicing in the immune system. Nat Rev Immunol. 4: 931-940.
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Rothrock, C., B. Cannon, B. Hahm and K.W. Lynch (2003) A conserved signal-responsive sequence mediates activation-induced alternative splicing of CD45. Mol. Cell 12: 1317-1324.
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Sheives, P. and K.W. Lynch (2002) Identification of cells deficient in signaling-induced alternative splicing by use of somatic-cell genetics. RNA 8:1473-1481.

Lynch, K.W. and A. Weiss (2001) A CD45 polymorphism associated with multiple sclerosis disrupts an exonic splicing silencer. J. Biol. Chem. 276: 24341-24347.
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Lynch, K.W. and A. Weiss (2000) A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol Cell Biol 20:70-80.

Hertel, K.J., K.W. Lynch and T. Maniatis (1997) Common themes in the function of transcription and splicing enhancers. Curr Opin Cell Biol. 9:350-357.
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Hertel, K.J., K.W. Lynch, E.C. Hsiao, E.H.-T. Liu and T. Maniatis (1996) Structural and functional conservation of the Drosophila doublesex splicing enhancer repeat elements. RNA 2:969-981.
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Lynch, K.W. and T. Maniatis (1996) Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes and Dev. 10:2089-2101.
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Lynch, K.W. and T. Maniatis (1995) Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes and Dev. 9:284-293.
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Sadowski, I., D. Neidbala, K. Wood and M. Ptashne (1991) Gal4 is phosphorylated as as consequence of transcriptional activation. Proc. Natl. Acad. Sci. USA 88: 10510-10514.

Ruden, D.M., J. Ma, Y. Li, K. Wood and M. Ptashne (1991) Generating yeast transcriptional activators containing no yeast protein sequences. Nature 350: 250-252.