The Translational Neuropathology Research Laboratory seeks to understand the molecular causes of age-related neurodegenerative diseases, in particular amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). We use an interdisciplinary approach to address the mechanisms of neurodegeneration, including molecular, biochemical, histologic, physiologic and behavioral methods. We are also interested in using and developing cutting-edge techniques such as high-resolution, multi-spectral, 3-dimensional confocal imaging and next-generation sequencing. The laboratory is comprised of a collaborative group of inquisitive researchers, led by Eddie Lee, Assistant Professor in the Division of Neuropathology in the Department of Pathology and Laboratory Medicine. It is our mission to understand the root causes of human neurodegenerative diseases so that our discoveries can translate into specific disease-modifying therapies.

Contact Us

Translational Neuropathology
Research Laboratory
612 Stellar Chance Laboratories
422 Curie Blvd
Philadelphia, PA 19104

News and Events

10/15/2015 - Alex's paper is accepted ("Transcriptomic changes due to cytoplasmic TDP-43 expression reveal dysregulation of histone transcripts and nuclear chromatin") Congratulations!

7/2015 - Analise starts her lab rotation at TNRL. Welcome!

4/27/2015 - Maribel wins 1st place for best oral presentation at the 4th Annual PREP Regional Symposium. Congrats!

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