New Alzheimer's Animal Model More Closely Mimics Human Disease
Penn study of amyloid plaques and tau tangles aims to accelerate discovery of new therapies
By injecting human Alzheimer's disease brain extracts of pathological tau protein (from postmortem donated tissue) into mice with different amounts of amyloid-β (Aβ) plaques in their brains, researchers from the Perelman School of Medicine at the University of Pennsylvania found that amyloid-β facilitates the interaction between the plaques and abnormal tau. This relationship promotes the spread of mutated tau proteins in neurons, which is the hallmark of long-term Alzheimer's disease.
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Henry Paulson, MD, PhD
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THE SCIENCE OF AGING NEWSLETTER
In this issue:
- The 2017 Joseph A. Pignolo Award in Aging Research
- New Alzheimer's Animal Model More Closely Mimics Human Disease
- Tips to avoid "cold stress"
- … and more!
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