Institute on Aging

Penn Study Shows that the "Epigenetic Landscape" is Protective in Normal Aging, Impaired in Alzheimer's Disease

Although certain genetic variants increase the risk of Alzheimer's disease (AD), age is the strongest known risk factor. But the way in which molecular processes of aging predispose people to AD, or become impaired in AD remains a mystery. 

A team of Penn Medicine researchers, including IOA Associate Director, Brad Johnson, MD, PhD, profiled the epigenomic landscape of AD brains, specifically in one of the regions affected early in AD. 

Full Penn Medicine News Release

Full Nature Neuroscience Publication

• An Epigenetic Link Between Aging and Alzheimer's Disease
  03/06/18
  The epigenomic landscape of Alzheimer’s disease brains is profiled in a new study from from the Perelman School of Medicine.
• Mouse Study Changes Perspective on Brain Immune Cells' Role in ALS Progression
  02/26/18
  Some immune cells in the brain can protect it from the damaging effects of faulty TDP-43 protein, preventing the progression…
• Big steps forward for mouse models that mimic tauopathy in humans
  12/14/17
  Researchers have long searched for an explanation for why there is so much variety in how abnormal aggregates of the protein…

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