Penn Study Shows that the "Epigenetic Landscape" is Protective in Normal Aging, Impaired in Alzheimer's Disease
Although certain genetic variants increase the risk of Alzheimer's disease (AD), age is the strongest known risk factor. But the way in which molecular processes of aging predispose people to AD, or become impaired in AD remains a mystery.
A team of Penn Medicine researchers, including IOA Associate Director, Brad Johnson, MD, PhD, profiled the epigenomic landscape of AD brains, specifically in one of the regions affected early in AD.
IOA IN THE NEWS
03/06/18The epigenomic landscape of Alzheimer’s disease brains is profiled in a new study from from the Perelman School of Medicine.
02/26/18Some immune cells in the brain can protect it from the damaging effects of faulty TDP-43 protein, preventing the progression…
12/14/17Researchers have long searched for an explanation for why there is so much variety in how abnormal aggregates of the protein…
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FEATURED VIDEOVideo Archive
Sylvan M. Cohen Annual Retreat and Poster Session 2018
"Impact of life course exposures on aging: Longevity reflects our experiences from day to day"
May 1, 2018
11:30am — 5:00pm
Smilow Center, Rubenstein Auditorium & Lobby
Co-sponsors: Penn's Population Aging Research Center (PARC)
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THE SCIENCE OF AGING NEWSLETTER
In this issue:
- The 2017 Joseph A. Pignolo Award in Aging Research
- New Alzheimer's Animal Model More Closely Mimics Human Disease
- Tips to avoid "cold stress"
- … and more!
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