Penn Study Shows that the "Epigenetic Landscape" is Protective in Normal Aging, Impaired in Alzheimer's Disease
Although certain genetic variants increase the risk of Alzheimer's disease (AD), age is the strongest known risk factor. But the way in which molecular processes of aging predispose people to AD, or become impaired in AD remains a mystery.
A team of Penn Medicine researchers, including IOA Associate Director, Brad Johnson, MD, PhD, profiled the epigenomic landscape of AD brains, specifically in one of the regions affected early in AD.
IOA IN THE NEWS
03/06/18The epigenomic landscape of Alzheimer’s disease brains is profiled in a new study from from the Perelman School of Medicine.
02/26/18Some immune cells in the brain can protect it from the damaging effects of faulty TDP-43 protein, preventing the progression…
12/14/17Researchers have long searched for an explanation for why there is so much variety in how abnormal aggregates of the protein…
Join the nearly 200 Institute on Aging Fellows and Associate Fellows and experience robust collaborative opportunities in aging at Penn, for funding opportunity alerts, pilot research grant opportunities, and updates on IOA activities.
FEATURED VIDEOVideo Archive
Penn Medicine's 5K for the IOA and the Memory Mile Walk
Save the date:
Sunday, September 23, 2018
8:00am @ Penn Park
MAKE A GIFT
Support aging-related research, education, and care at the IOA!
THE SCIENCE OF AGING NEWSLETTER
In this issue:
- The 11th Annual Vincent J. Cristofalo Lectureship
- Brain Immune System is Key to Recovery from Motor Neuron Disease
- FY 2019 Pilot Award Announcement
… and more!
Download the 2018 Spring Newsletter here
© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Site Design: PMACS Web Team.