By Nicolette Calcavecchia
Last week, researchers and clinicians from around the world, including many from Penn, joined in Philadelphia for the 2024 Alzheimer's Association International Conference (AAIC) to discuss recent advances in Alzheimer's disease and related dementias.
Some highlights of Penn presenters from this year’s conference are featured below:
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By Nicolette Calcavecchia
The IOA is pleased to introduce Gabriel Elias as the new IOA-funded PennPREP Scholar for 2024-2025.
Gabriel is a graduate of Rutgers University where he obtained bachelor’s degrees in biology and psychology. During his time as a PennPREP Scholar, Gabriel will work in the neuroscience lab of David J. Irwin, MD, Associate professor of Neurology at Penn Medicine and Co-director of the Penn Frontotemporal Degeneration (FTD) Center. His work will focus on incorporating histopathology of human brain tissue to understand brain-behavior correlations to neurodegenerative disease diagnosis with a particular emphasis on Primary Progressive Aphasia (PPA).
“Through PennPREP, I hope to develop…
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By Nicolette Calcavecchia
The Institute on Aging hosted its 2024 Vincent J. Cristofalo Annual Lectureship on Monday, June 3. This year’s keynote speaker, Mark Mintun, MD, Vice President of Pain and Neurodegeneration Research and Clinical Development Chief Medical Officer of Avid Radiopharmaceuticals, discussed the background of Alzheimer’s disease (AD) pathology and its clinical course, the development of pathology biomarkers, and recent developments in disease modifying therapy specifically highlighting Donanemab.
He started by discussing the timeline of Alzheimer’s disease and related disorders (ADRD) and the diagnostic evolution of AD which is now defined by presence of pathology. He explained the advancement of identifying amyloid-beta…
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By Joey Dupree, IOA Intern
During his lecture for the IOA’s 2023 Sylvan M. Cohen Annual Retreat, Jason Karlawish, MD, co-director of the Penn Memory Center shared his thoughts on how and why society and the field of aging research has reached the current state of nomenclature of Alzheimer’s Disease and dementia and the problems that exist within this nomenclature.
Dr. Karlawish started his lecture titled " “The Nomenclature of Alzheimer’s Disease: Too Many Ideas in One Word†by discussing the current state of nomenclature for Alzheimer’s Disease and other diseases that result in cognitive impairment. Dr. Karlawish lays out two hypothetical scenarios, one in…
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By Nicolette Calcavecchia
On April 9, 2024 the Institute on Aging (IOA) and Penn Center for Genome Integrity (PCGI) co-hosted a symposium titled "Threats to the Neuronal Genome."
The IOA and PCGI share missions to bring basic, translational, and clinical researchers together and in recognition of this mission and the role of genome maintenance in neurodegenerative disease, the symposium covered several related topics including neuronal DNA damage and neuronal somatic variants. The full-day symposium featured keynotes by Drs. Michael B. Miller, Li-Huei Tsai, and Andre Nussenzweig, with trainee talks as well as a poster session.
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