Dr. David Wolk is an Associate Professor of Neurology in the Cognitive Neurology Division of the University of Pennsylvania Perelman School of Medicine and acting co-director of the Penn Memory Center.
Dr. Wolk completed his medical training at Johns Hopkins University, a Neurology residency at the University of Pennsylvania, and clinical Fellowship training in Cognitive and Behavioral Neurology at Brigham and Women’s Hospital/Harvard Medical School where he also completed a post-doctoral research fellowship studying memory in Alzheimer’s Disease. Prior to his return to Penn, he was an Assistant Professor at the University of Pittsburgh and a member of their Alzheimer’s Disease Research Center.
Dr. Wolk’s research has focused on memory measures and other markers that allow for early detection of Alzheimer’s disease (AD). One of the major challenges in the diagnosis of very early Alzheimer’s disease is differentiating the memory failures associated with the normal aging process from those reflecting early AD pathology. As such, his research currently focuses on memory changes in healthy aging, Mild Cognitive Impairment, and AD using Event-Related Potentials (a form of EEG), MRI (including structural and functional measures), and novel psychometric testing. It is hoped that these methods will contribute to early detection and intervention with emerging treatment modalities.
Dr. Lee received his medical degree and doctoral degree in Neuroscience from Penn, followed by clinical training in Anatomic Pathology and Neuropathology from the Hospital of the University of Pennsylvania. He is an Associate Professor of Pathology and Laboratory Medicine and a practicing neuropathologist in the Division of Neuropathology, as well as co-leader of the U19 Center for Alpha-Synuclein Strains neuropathology core.
His research involves using of advanced molecular, biochemical and histologic techniques to analyze brain tissue in study the molecular pathways associated with neuropathologic inclusions in frontotemporal lobar degeneration, amyotrophic lateral sclerosis, Alzheimer's disease, and Trauma-Related Neurodegeneration.
His goals include maintaining a world-class experimental neuropathology laboratory and supporting lab members in our collective mission to increase our understanding of the causes and cures of aging-related neurodegenerative diseases.
Dr. Jedrziewski received her PhD from the University of Pennsylvania in 1991 and has worked in gerontology and geriatrics for the past twenty-five years. Currently, she serves as the Deputy Director of the Institute on Aging (IOA) at the University of Pennsylvania, where she is responsible for overseeing all of the daily administrative activities of the IOA, while working closely with John Trojanowski, MD, PhD, IOA Director, to shape and implement a vision for the future of the IOA.
Prior to taking on this role, Dr. Jedrziewski planned and directed Penn Partners in Healthy Living (PPHL), a Penn consumer membership program with over 90,000 members age 50 and older. Before becoming Director of PPHL, Dr. Jedrziewski spent many years as a senior-level research Project Manager at Penn, working closely with various principal investigators on developing research proposals, co-authoring papers and reports, and directing all aspects of the various research projects, predominately in geriatrics/gerontology.
Before going to Penn in 1985, Dr. Jedrziewski worked directly with Philadelphia older adults at the Philadelphia Center for Older People (now Philadelphia Senior Center), starting as a drama specialist, moving on to become the Northern Branch Program Director and finally Coordinator of the Northern Branch. She continues to provide training to direct service workers through Philadelphia's Area Agency on Aging, the Philadelphia Corporation for Aging.