The mission of the Center for Neurodegenerative Disease Research (CNDR) is to promote and conduct multidisciplinary clinical and basic research to increase the understanding of the causes and mechanisms leading to brain dysfunction and degeneration in neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Lewy body dementia (LBD), Frontotemporal degeneration (FTD), Amyotrophic lateral sclerosis (ALS), Primary lateral sclerosis (PLS), Motor neuron disease (MND), and related disorders that occur increasingly with advancing age. Implicit in the mission of the CNDR are two overarching goals: 1.) Find better ways to cure and treat these disorders, 2. Provide training to the next generation of scientists.
“My goal for CNDR is not only to collaborate with researchers at Penn and from institutions across the globe with the mutual goal of finding better ways to diagnose and treat neurodegenerative diseases, but also to inspire and encourage the next generation of scientists on the importance of investigating these disorders that occur more frequently with advancing age.” – Virginia M.-Y. Lee, PhD, Director, CNDR
John Q. Trojanowski, MD, PhD | 1946 - 2022
February 8, 2022
We are sad to announce the passing of our colleague and friend, John Q. Trojanowski, who we all regard as a larger than life leader in neurodegenerative disease research. We will miss his probing intellect, limitless enthusiasm and energy, and ever present personality. He passed away peacefully with Virginia, his partner in every aspect of his life, by his side. I know the thoughts of our entire community go out to Virginia and her family. While today is a difficult day for so many of us, we do look forward to finding ways to celebrate his remarkable life in the future.
Sex Differences in Outcomes of Acute Myocardial Injury After Stroke
Tuesday, February 27, 2024
CONCLUSIONS: The prevalence of acute myocardial injury after ischemic stroke and its association with mortality and greater disability might be sex-dependent.
Author Correction: O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
Tuesday, February 27, 2024
Posttraumatic Epilepsy and Dementia Risk
Monday, February 26, 2024
CONCLUSIONS AND RELEVANCE: In this community-based cohort, there was an increased risk of dementia associated with PTE that was significantly higher than the risk associated with head injury or seizure/epilepsy alone. These findings provide evidence that PTE is associated with long-term outcomes and supports both the prevention of head injuries via public health measures and further research into the underlying mechanisms and the risk factors for the development of PTE, so that efforts can also...