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Mission
The mission of the Center for Neurodegenerative Disease Research (CNDR) is to promote and conduct multidisciplinary clinical and basic research to increase the understanding of the causes and mechanisms leading to brain dysfunction and degeneration in neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Lewy body dementia (LBD), Frontotemporal degeneration (FTD), Amyotrophic lateral sclerosis (ALS), Primary lateral sclerosis (PLS), Motor neuron disease (MND), and related disorders that occur increasingly with advancing age. Implicit in the mission of the CNDR are two overarching goals: 1.) Find better ways to cure and treat these disorders, 2. Provide training to the next generation of scientists.
“My vision for CNDR is to create a world with effective interventions to prevent and cure aging-related neurodegenerative diseases.” – Eddie Lee, MD, PhD, Director of CNDR
John Q. Trojanowski, MD, PhD | 1946 - 2022
In loving memory of John Q. Trojanowski, MD, PhD
Latest Research
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Clinicopathologic Evaluation of Amyloid Clearance in Alzheimer Disease
Sunday, July 12, 2026
CONCLUSIONS AND RELEVANCE: In this case report, areas of extensive amyloid clearance after amyloid-targeting therapy were associated with less downstream neuropathologic change. In addition, amyloid clearance appears to preferentially occur in the gyral crests. Future studies should evaluate the differential mechanisms involved in amyloid clearance from superficial and deep cortical layers and in gyri and sulci because extensive amyloid clearance may be necessary to achieve downstream...
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Sleep Disturbance, Physical Frailty, and Risk of Cognitive Impairment and Dementia in Older Adults with Subjective Cognitive Decline: A 10-Year Longitudinal Study
Saturday, July 11, 2026
CONCLUSIONS: Physical prefrailty/frailty is a significant factor of cognitive impairment in older adults with SCD, while the effect of sleep disturbance may vary by frailty status.
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Thoracic limb stride length is associated with cognitive impairment in aging dogs
Friday, July 10, 2026
CONCLUSION: These findings support the use of thoracic limb stride length as an objective, scalable functional mobility measure that reflects changes associated with cognitive decline and may be a useful tool for research and clinical monitoring of aging in dogs.