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Mission
The mission of the Center for Neurodegenerative Disease Research (CNDR) is to promote and conduct multidisciplinary clinical and basic research to increase the understanding of the causes and mechanisms leading to brain dysfunction and degeneration in neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Lewy body dementia (LBD), Frontotemporal degeneration (FTD), Amyotrophic lateral sclerosis (ALS), Primary lateral sclerosis (PLS), Motor neuron disease (MND), and related disorders that occur increasingly with advancing age. Implicit in the mission of the CNDR are two overarching goals: 1.) Find better ways to cure and treat these disorders, 2. Provide training to the next generation of scientists.
“My vision for CNDR is to create a world with effective interventions to prevent and cure aging-related neurodegenerative diseases.” – Eddie Lee, MD, PhD, Director of CNDR
John Q. Trojanowski, MD, PhD | 1946 - 2022
In loving memory of John Q. Trojanowski, MD, PhD
Latest Research
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Epidemiology of visuospatial impairment in older adults: the Harmonized Cognitive Assessment Protocol
Thursday, July 23, 2026
BACKGROUND AND OBJECTIVES: This study aimed to determine the prevalence of visuospatial impairment in a nationally representative sample of older adults and identify self- and informant-reported functional measures associated with visuospatial dysfunction.
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Ethical Considerations of Artificial Intelligence in Dementia Research: A Review of Reviews
Thursday, July 23, 2026
BACKGROUND AND OBJECTIVES: To examine the ethical considerations related to artificial intelligence technologies in dementia across diagnostic, management, and to synthesize these considerations using existing artificial intelligence and bioethical ethics principles.
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Norepinephrine-mediated regulation of endogenous Aβ<sub>42</sub> peptide levels: effects of noradrenergic depletion and restoration
Thursday, July 23, 2026
The locus coeruleus (LC), a cluster of noradrenergic neurons in the dorsal pons, is the brain's main source of norepinephrine (NE), crucial for memory, cognition, and stress response. NE dysregulation has been linked to mood disorders, chronic stress, and neurodegenerative diseases such as Alzheimer's disease (AD). Amyloid-β(42) (Aβ(42)) is a key protein in AD pathology, and forms plaques that trigger neurodegeneration. Studies show elevated Aβ(42) levels are associated with anxiety symptoms,...