Job opportunities

Our lab welcomes talented and highly motivated individuals from a variety of backgrounds and expertise. We are currently recruiting team members for the following positions.

Due to the continued growth of our program, the CSTL, in partnership with the Division of Translational Medicine & Human Genetics and the Fajgenbaum lab, is searching for a talented, experienced, and motivated Lead Researcher to direct all Castleman disease and cytokine storm-related research projects, performing conceptual, bench, and computational research. Working in partnership with the Principal Investigator of the CSTL, the Lead Researcher will conceptualize and develop the work-plans for current and future research projects spanning the spectrum from basic science to clinical trials. In each case, the Lead Researcher will work with other members of the lab, including the Operations Director, to ensure successful execution of in vitro and in vivo experiments while working cross-functionally with core labs and resources. Working independently, the Lead Researcher will design, optimize, and implement complex experiments within specified timelines, interpret the results, and present research both externally and internally, as well as contribute to writing/reviewing grants and manuscripts, progress reports, protocols, and SOPs. This position offers the opportunity to contribute to the strategic direction of the CSTL and interface broadly with internal (PI, data coordinators, biostatisticians, researchers, laboratory technicians, students, etc.) and external (federal funding bodies, pharmaceutical collaborators, non-profit partners, external collaborators, etc.) stakeholders from around the world to assure rapid progression of the science towards medical breakthroughs that help patients. He or she will report directly to the Principal Investigator/Founding Director of the CSTL and recruit, train, supervise, and mentor laboratory personnel, graduate students, fellows, and scientific collaborators.

 

Several projects homing in on novel insights into the etiology of and cell types, signaling pathways, and cytokines that drive idiopathic multicentric Castleman disease (iMCD) pathogenesis as well as basic insights into human immunology and cytokine storms more generally are underway that need to be driven toward publication and dissemination. These projects include investigation of the first two novel therapeutic targets (mammalian Target of Rapamycin and JAK/STAT) discovered in iMCD in 25 years (using flow cytometry, phospho-flow, and immunohistochemistry/immunofluorescence), which is funded through the first R01 awarded for iMCD research, whole exome sequencing of lymph node and constitutional DNA to search for pathological variants, single-cell transcriptional and T/B cell repertoire profiling of peripheral blood mononuclear cells, serum proteomics and pathogen discovery, and investigation of stromal cells and their chemokines in iMCD and human immunology. A significant number of publications are anticipated from these projects. Several already funded projects are also waiting for the Lead Researcher to be designed and initiated, such as correlative biomarker analyses for an ongoing clinical trial of a novel treatment identified by the Fajgenbaum Lab.

 

Qualified candidates will have expertise in research planning, direct experience or familiarity with high-dimensional flow cytometry, cutting-edge sequencing/omics techniques (WES, WGS, scRNAseq, proteomics, etc.), immune repertoire profiling, functional immunological assays, studies using human tissue, and experimental systems, and an advanced understanding of human immunology. This is a unique opportunity to join a highly motivated, patient-focused team that works closely with international collaborators to make and publish novel discoveries that will have a significant impact on patients who have diseases with major unmet medical need. Joining the CSTL offers scientific professionals the unique opportunity of growing his/her leadership experience, seeing his/her research go from bench to bedside, and making discoveries that could lead to cures for deadly conditions such as COVID-19 and Castleman disease.

 

Position contingent upon funding.

To learn more about this opportunity and/or to apply visit the full listing here.  

If you have any additional questions after viewing the full listing, please email CSTL@pennmedicine.upenn.edu 

The CSTL, in partnership with the Division of Translational Medicine & Human Genetics and the Fajgenbaum lab, is now expanding CORONA to include a new STORM (Systematic Tracker Of Repurposed/new Medicines) tool and searching for a talented, experienced, and motivated bioinformatician/computational biologist to perform analyses on this expansive dataset and generate meaningful insights. In addition to continuing to track all treatments administered to COVID-19 patients, STORM will also integrate and track all pre-clinical treatment data and clinical trial data and enable the search for treatment patterns, identification of promising drugs that need to be evaluated in clinical trials, and facilitate the development of recommendations to strengthen the global effort to combat COVID-19. In one place, government agencies, academic researchers, philanthropic organizations, and biopharmaceutical companies will be able to access all data at no cost on all potential treatments for COVID-19. The bioinformatician/computational biologist will be tasked with conceptualizing and developing analytical plans, supporting database development, performing analyses of data in CORONA and external data sources, interpreting results, and collaborating with government, industry, philanthropic, and academic partners to achieve our overarching goal of accelerating the identification of effective COVID-19 treatments. This position offers the opportunity to contribute to a major national initiative directed against COVID-19 and interface broadly with internal and external (federal government, pharmaceutical collaborators, non-profit partners, external academic collaborators, etc.) stakeholders from around the world to assure rapid progression of the science towards medical breakthroughs that help patients. Beyond COVID-19, there are exciting opportunities to perform analyses to elucidate understanding of other cytokine storm disorders with major unmet medical need. The CSTL combines ‘omic analyses of patient biospecimens, hypothesis-driven basic science research, and clinical data analyses to discover and pursue novel therapeutic approaches for cytokine storms through clinical trials and adoption in clinical practice. A talented bioinformatician/computational biologist is needed to perform these multi-omic analyses.

 

Qualified candidates will have expertise in bioinformatics/computational biology, familiarity with virology, immunology, and drug repurposing, and experiences performing relevant analyses. This is a unique opportunity to join a highly motivated, patient-focused team that works closely with international collaborators and the federal government to make and publish novel discoveries that will have a significant impact on patients who have COVID-19 and other diseases with major unmet medical need.

 

Position contingent upon funding.

To learn more about this opportunity and/or to apply visit the full listing here.  

If you have any additional questions after viewing the full listing, please email CSTL@pennmedicine.upenn.edu 

The CSTL, in partnership with the Division of Translational Medicine & Human Genetics and the Fajgenbaum lab, is now expanding CORONA to include a new STORM (Systematic Tracker Of Repurposed/new Medicines) tool and searching for a talented, experienced, and motivated data coordinator to extract, interact with, and analyze data from this expansive dataset. In addition to continuing to track all treatments administered to COVID-19 patients, STORM will also integrate and track all pre-clinical treatment data and clinical trial data and enable the search for patterns, identification of promising drugs that need to be evaluated in clinical trials, and facilitate the development of recommendations to strengthen the global effort to combat COVID-19. In one place, government agencies, academic researchers, philanthropic organizations, and biopharmaceutical companies will be able to access all data at no cost on all potential treatments for COVID-19. The data coordinator will be tasked with performing manual data extractions and database entry from the published literature and other data sources, supporting automated extractions, database querying and management, and supporting analyses of data to help achieve our overarching goal of accelerating the identification of effective COVID-19 treatments. He or she will report directly to the CORONA Managing Director. This position offers the opportunity to contribute to a major national initiative directed against COVID-19 and interface broadly with stakeholders from around the world.

 

Qualified candidates will have experiences with data extraction, an understanding of basic medical terminology, and familiarity with virology, immunology, and drug repurposing. This is a unique opportunity to join a highly motivated, patient-focused team that works closely with international collaborators and the federal government to make and publish novel discoveries that will have a significant impact on patients who have COVID-19 and other diseases with major unmet medical need.

 

Position contingent upon funding.

To learn more about this opportunity and/or to apply visit the full listing here.  

If you have any additional questions after reviewing the full listing, please email CSTL@pennmedicine.upenn.edu.  

The Research Administration Coordinator at the Center for Cytokine Storm Treatment & Laboratory (CSTL) will be responsible for tracking the acquisition and receipt of all materials. Once received, the Coordinator will compile patient medical records for data extraction. The Coordinator will also facilitate the staining and scanning of lymph node tissue for use in ACCELERATE and various research projects. The Coordinator will interface with institutions across the United States and occasionally outside of the United States by phone, email, and fax in order to request and receive the required data. The Coordinator will work in liaison with key members of the CSTL, CHOP Pathology Core, external hospitals, clinics, and academic centers process. The Research Administration Coordinator will also be responsible for addressing and correcting database queries as needed. They will independently review and assess patient medical records in order to address data queries. They will provide regular updates to the research team and prepare agendas, data summaries, tables, and graphs as needed.

 

Candidates must possess strong organizational skills and attention to detail; willingness to take initiative; ability to work independently but also know when to seek help, and to work as part of a fast paced and integrated team. They must be comfortable managing repetitive tasks effectively and independently. The individual must possess strong decision making skills and the ability to work uninterrupted on a focused project. Experience reviewing medical records is a plus but not required.

 

Position contingent upon funding.

To learn more about this opportunity and/or to apply visit the full listing here.  

If you have any additional questions after reviewing the full listing, please email CSTL@pennmedicine.upenn.edu.  

The Clinical Research Coordinator’s primary responsibilities will involve identifying, interpreting and extracting key medical record data into the registry database from patients in the U.S. and integrating multiple data sources to assess response to therapies, adverse events, and clinical courses, in collaboration with the Principal Investigator and Associate Director. They may also be responsible for reviewing patient hematopathology and selecting lymph node slides for the study Certification and Access Subcommittee. They will occasionally interact directly with Castleman disease patients, manage data extraction protocols, track metrics, prepare tables, graphs and descriptive summaries of data for presentations, progress reports, grant applications and manuscripts. They may also be expected to initiate and independently drive forward other projects in the CSTL, such as analyzing immunofluorescence, immunohistochemistry, or in situ hybridization or contributing to studies related to hematopathology.

 

Candidates must possess strong organizational skills and attention to detail; willingness to take initiative; ability to work independently but also know when to seek help, and to work as part of a fast paced and integrated team. The individual must possess strong decision making skills and the ability to work uninterrupted on a focused project. Experience reviewing medical records is a plus but not required.

 

Position contingent upon funding.

To learn more about this opportunity and/or to apply visit the full listing here.  

If you have any additional questions after reviewing the full listing, please email CSTL@pennmedicine.upenn.edu.