Perelman School of Medicine at the University of Pennsylvania

The OCRC Tumor BioTrust Collection

Publications

Representative Publications

2021

  Intra-Tumoral Nerve-Tracing in a Novel Syngeneic Model of High-Grade Serous Ovarian Carcinoma.
Barr JL, Kruse A, Restaino AC, Tulina N, Stuckelberger S, Vermeer SJ, Williamson CS, Vermeer DW, Madeo M, Stamp J, Bell M, Morgan M, Yoon J-Y, Mitchell MA, Budina A, Omran DK, Schwartz LE, Drapkin R, Vermeer PD. Cells. 2021; 10(12):3491.
https://doi.org/10.3390/cells10123491

  Systematic analysis of CD39, CD103, CD137, and PD-1 as biomarkers for naturally occurring tumor antigen-specific TILs.
Eiva MA, Omran DK, Chacon JA, Powell DJ Jr.
Eur J Immunol. 2021 Sep 10. doi: 10.1002/eji.202149329. Epub ahead of print.
https://pubmed.ncbi.nlm.nih.gov/34505280/

  CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.
Rodriguez-Garcia A, Lynn RC, Poussin M, Eiva MA, Shaw LC, O'Connor RS, Minutolo NG, Casado-Medrano V, Lopez G, Matsuyama T, Powell DJ Jr.
Nat Commun. 2021 Feb 9;12(1):877. doi: 10.1038/s41467-021-20893-2.
https://pubmed.ncbi.nlm.nih.gov/33563975/
 
  Inhibition of relaxin autocrine signaling confers therapeutic vulnerability in ovarian cancer.
Burston HE, Kent OA, Communal L, Udaskin ML, Sun RX, Brown KR, Jung E, Francis KE, La Rose J, Lowitz JK, Drapkin R, Mes-Masson AM, Rottapel R.
J Clin Invest. 2021 Feb 9:142677. doi: 10.1172/JCI142677.
https://pubmed.ncbi.nlm.nih.gov/33561012/

2020

2020

  Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F.
Nat Commun. 2020 Jul 24;11(1):3726. doi: 10.1038/s41467-020-17127-2.
https://pubmed.ncbi.nlm.nih.gov/32709856/
 
  PARP Theranostic Auger Emitters Are Cytotoxic in BRCA Mutant Ovarian Cancer and Viable Tumors from Ovarian Cancer Patients Enable Ex-Vivo Screening of Tumor Response. Molecules.
Riad A, Gitto SB, Lee H, Winters HD, Martorano PM, Hsieh CJ, Xu K, Omran DK, Powell DJ Jr, Mach RH, Makvandi M.
2020 Dec 19;25(24):6029. doi: 10.3390/molecules25246029.
https://pubmed.ncbi.nlm.nih.gov/33352773/

  An autologous humanized patient-derived-xenograft platform to evaluate immunotherapy in ovarian cancer
Sarah B. Gitto, Hyoung Kim, Stavros Rafail, Dalia K. Omran, Sergey Medvedev, Yasuto Kinose, Alba Rodriguez-Garcia, Ahron J. Flowers, Haineng Xu, Lauren E. Schwartz, Daniel J. Powell Jr., Fiona Simpkins
Gynecologic Oncology 156 (2020) 222e232.

  CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies
Alba Rodriguez-Garcia, Prannda Sharma, Mathilde Poussin, Alina C. Boesteanu, Nicholas G. Minutolo, Sarah B. Gitto, Dalia K. Omran, Matthew K. Robinson, Gregory P. Adams, Fiona Simpkins, and Daniel J. Powell, Jr.
Molecular Therapy (2019), https://doi.org/10.1016/j.ymthe.2019.11.028.

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2019

  Imaging Collagen Alterations in STICs and High Grade Ovarian Cancers in the Fallopian Tubes by Second Harmonic Generation Microscopy
Eric C. Rentchler, Kristal L. Gant, Ronny Drapkin, Manish Patankar and Paul J. Campagnola,*
Cancers 2019, 11, 1805; doi:10.3390/cancers11111805.

  CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary
Shoumei Bai, Wanhong Zhu, Lan Coffman, Anda Vlad, Lauren E. Schwartz, Esther Elishaev, Ronny Drapkin and Ronald J Buckanovich
Cancers 2019, 11, 1710; doi:10.3390/cancers11111710.

  Innervation of cervical carcinoma is mediated by cancer-derived exosomes
Christopher T. Lucido, Emily Wynja, Marianna Madeoa, Caitlin S.Williamson, Lauren E. Schwartz, Brittney A. Imblumc, Ronny Drapkin, Paola D. Vermeer
Gynecol Oncol. 2019 Jul;154(1):228-235.

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