Faculty

Jonathan J Miner, M.D., Ph.D.

Associate Professor of Medicine (Rheumatology)

Department: Medicine

Graduate Group Affiliations

Contact information

522B Johnson Pavilion
3610 Hamilton Walk
Philadelphia, PA 19104

Office: 215-573-4109

Email:
jonathan.miner@pennmedicine.upenn.edu

Education:
B.A. (Russian)
BYU, 2002.
B.S. (Zoology)
BYU, 2002.
Ph.D. (Biochemistry and Molecular Biology)
University of Oklahoma, 2008.
M.D. (Medicine)
University of Oklahoma, 2010.

Links
RVCL Research Center
Miner Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Dr. Miner sees patients with ultra-rare autoinflammatory diseases and vasculopathies caused by single gene mutations. This includes RVCL (also known as RVCL-S), AGS, SAVI, COPA syndrome, and others.

Description of Research Expertise

The Miner laboratory studies the intersection of autoimmunity and antiviral immunity. This includes studies of rare rheumatic diseases caused by mutations in genes that regulate immune responses to viruses, such as the TREX1, cGAS, STING, RIG-I, and STAT1 genes. The Miner laboratory is also developing novel therapeutics for rare diseases, and is conducting whole-genome CRISPR/Cas9 screens to discover novel regulators of these pathways.

Examples of diseases studied in the Miner laboratory include:
* Retinal vasculopathy with cerebral leukoencephalopathy (RVCL), caused by mutations in TREX1.
* STING-associated vasculopathy with onset in infancy (SAVI), caused by mutations in STING.
* Chronic mucocutaneous candidiasis (CMC), caused by mutations in STAT1
* Monogenic systemic lupus erythematosus (SLE), caused by mutations in NF-kB signaling pathways
* Hemophagocytic lymphohistiocytosis (HLH), caused by mutations in viral RNA-sensing pathways
* Viral infections (e.g., models of chikungunya viral arthritis, and models of Zika virus, West Nile virus, bunyavirus, coronavirus, and herpesvirus pathogenesis).

Selected Publications

Platt DJ, Lawrence D, Qian W, Rodger R, Schriefer L, Miner CA, Menos AM, Kennedy EA, Peterson ST, Stinson WA, Baldridge MT, Miner, JJ: Transferrable protection by gut microbes against STING-associated lung disease. Cell Rep. 35(6): 109133, May 2021.

Miner JJ, Platt DJ, Ghaznavi CM, Chandra P, Santeford A, Menos AM, Dong Z, Wang ER, Qian W, Karozichian ES, Philips JA, Apte RS.: "HSV-1 and Zika virus but not SARS-CoV-2 replicate in the human cornea and are restricted by corneal type III interferon." Cell Rep. 33(5): 108339, Nov 2020.

Ford AL, Chin V, Fellah S, Binkley MM, Bodin A, Balasetti V, Taiwo Y, Kang P, Lin D, Jen J, Grand G, Bogacki M, Liszewski K, Hourcade D, Chen Y, Hassenstab J, Lee JM, An H, Miner JJ, Atkinson JP.: "Lesion evolution and neurodegeneration in RVCL-S, a monogenic microvasculopathy." Neurology. 95(14): 1918-31, Oct 2020.

Bennion BG, Croft CA, Ai TL, Qian W, Menos AM, Miner CA, Fremond ML, Doisne JM, Andhey PS, Platt DJ, Bando JK, Wang ER, Luksch H, Molina TJ, Robison EDO, Artyomov MN, Rosen-Wolff A, Colonna M, Rieux-Laucat F, Di Santo JP, Neven B, Miner JJ. : "STING gain-of-function disrupts lymph node organogenesis and innate lymphoid cell development in mice." Cell Rep. 31(11): 107771, Jun 2020.

Luksch H, Stinson WA, Platt DJ, Qian W, Kalugotla G, Miner CA, Bennion BG, Gerbaulet A, Rösen-Wolff A, Miner JJ.: "STING-associated lung disease in mice relies on T cells but not type I interferon" J Allergy Clin Immunol. 144(1): 154-266, July 2019.

Bennion BG, Ingle H, Ai TL, Miner CA, Platt DJ, Smith AM, Baldridge MT, Miner JJ.: "A human gain-of-function STING mutation causes immunodeficiency and gammaherpesvirus-induced pulmonary fibrosis in mice" J Virol. 93(4): e01806-18, Feb 2019.

Qian W, Miner CA, Ingle H, Platt DJ, Baldridge MT, Miner JJ.: "A human STAT1 gain-of-function mutation impairs CD8+ T cell responses against gammaherpesvirus-68." J Virol. 93(19): 307-19, Sept 2019.

Platt DJ, Smith AM, Arora N, Diamond MS, Coyne CB, Miner JJ.: "Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice." Sci Transl Med. 426(10): 7090, Jan 2018.

Warner JD, Irizarry-Caro RA, Bennion BG, Ai TL, Smith AM, Miner CA, Sakai T, Gonugunta VK, Platt DJ, Yan N, Miner JJ.: "STING-associated vasculopathy develops independently of IRF3 in mice" J Exp Med. 214(11): 3279-92, Nov 2017.

Miner JJ, Cao, B, Govero, J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS: "Zika virus infection during pregnancy in mice causes placental damage and fetal demise." Cell. 165(5): 1081-91, May 2016.