Craig H. Bassing, Ph.D.
Professor of Pathology and Laboratory Medicine
Member, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania
Member, Institute for Immunology
Member, Abramson Cancer Center - Pediatric Oncology Research
Member, Division of Cancer Pathobiology, Children's Hospital of Philadelphia, University of Pennsylvania
Investigator, Abramson Family Cancer Research Institute
Department: Pathology and Laboratory Medicine
Contact information
Children's Hospital of Philadelphia
4054 Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
4054 Colket Translational Research Building
3501 Civic Center Blvd.
Philadelphia, PA 19104
Office: 267-426-0311
Fax: 267-426-2791
Fax: 267-426-2791
Email:
bassing@mail.med.upenn.edu
bassing@mail.med.upenn.edu
Graduate Group Affiliations
Education:
B.A. (Biology)
The Johns Hopkins University, 1992.
Ph.D. (Biology)
Duke University, 1997.
B.A. (Biology)
The Johns Hopkins University, 1992.
Ph.D. (Biology)
Duke University, 1997.
Post-Graduate Training
Research Fellow in Molecular Immunology, CBR Institute for Biomedical Research , 1997-2000.
Research Fellow in Genetics, Harvard Medical School, 1997-2002.
Research Fellow in Medicine, Boston Children's Hospital, 1997-2002.
Research Fellow in Molecular Immunology, Irvington Institute for Immunological Research, 1997-2000.
Research Associate in Molecular Immunology, Howard Hughes Medical Institute, 2000-2003.
Research Fellow in Cancer Genetics , Lymphoma Research Foundation, 2003-2005.
Permanent linkResearch Fellow in Molecular Immunology, CBR Institute for Biomedical Research , 1997-2000.
Research Fellow in Genetics, Harvard Medical School, 1997-2002.
Research Fellow in Medicine, Boston Children's Hospital, 1997-2002.
Research Fellow in Molecular Immunology, Irvington Institute for Immunological Research, 1997-2000.
Research Associate in Molecular Immunology, Howard Hughes Medical Institute, 2000-2003.
Research Fellow in Cancer Genetics , Lymphoma Research Foundation, 2003-2005.
Selected Publications
Glynn, R.A. and Bassing, C.H.: ATM-Dependent Phosphorylation of Nemo SQ Motifs is Dispensable for Nemo-Mediated Gene Expression Changes in Response to DNA Double Strand Breaks. The Journal of Immunology In Press, 2024.Allyn, B.M., Hayer, K.E., Oyeniran, C., Nganga, V., Lee, K., Mishra, B., Sacan, A., Oltz, E.M., and Bassing, C.H.: Locus Folding Mechanisms Determine Modes of Antigen Receptor Gene Assembly. The Journal of Experimental Medicine 221, 2024.
Culberson, E.J., Shields, K.C., Glynn, R.A., Allyn, B.M., Hayer, K.E., and Bassing, C.H.: The Cyclin D3 Protein Enforces Monogenic TCRb Expression by Mediating TCRb Protein Signaled Feedback Inhibition of Vb Recombination The Journal of Immunology 212, 2024.
Burn, T.N., Miot, C., Gordon, S.M., Culberson, E.J., Diamond, T., Kreiger, P.A., Hayer, K.E., Bhattacharyya, A., Jones, J.M., Bassing, C.H.*, and Behrens, E.M.* *Co-corresponding authors: The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRb and a Genes and Influences Development of ab T Cell Lineages. The Journal of Immunology 209, 2022.
Glynn, R.A. and Bassing, C.H.: Nemo-dependent, ATM-mediated signals from RAG DNA breaks at Igk feedback inhibit Vk recombination to enforce Igκ allelic exclusion. The Journal of Immunology 208: 371-383, 2022.
Wu, G., Culberson, E.J., Allyn, B.M., and Bassing, C.H.: Poor-Quality Vb Recombination Signal Sequences and the DNA Damage Response ATM Kinase Collaborate to Establish TCRb Gene Repertoire and Allelic Exclusion. The Journal of Immunology doi: 10.4049/jimmunol.2100489, 2022.
Culberson, E.J. and Bassing, C.H.: Monogenic TCRb Assembly and Expression is Paramount for Uniform Antigen Receptor Specificity of Individual ab T Lymphocytes. The Journal of Immunology 209, 2022.
Beilinson, H.A., Glynn, R.A., Yadavailli, A.D., Xiao, J., Corbett, E., Saribasak, H., Arya, R., Miot, C., Bhattacharyya, A., Jones, J.M., Pongubala, J., Bassing, C.H., and Schatz, D.G. : The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination. Journal of Experimental Medicine. Oct 4;218(10):e20210250. doi: 10.1084/jem.20210250. (eds.). 218(10): :e20210250, 2021.
Dauphers, D.J., Wu, G.S., Bassing, C.H., and Krangel, M.S.: Molecular Analysis of Mouse T Cell Receptor α and β Gene Rearrangements Methods in Molecular Biology In Press, 2021.
Burn, Thomas, N., Lee, Kyutae, D., Dawany, N., Robertson, Tanner, F., Fisher, Megan, R., Bassing, Craig H., and Behrens, Edward M. : A Spontaneous Rag1 Nonsense Mutations Unveils Naturally Occurring N-truncated RAG1 Isoforms ImmunoHorizons 4: 119-128, 2020.