Foteini Mourkioti, PhD

faculty photo
Assistant Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery
Graduate Group Affiliations

Contact information
McKay Orthopaedic Research Laboratory
377A Stemmler Hall
3450 Hamilton Walk
Philadelphia, PA 19104-6081
Office: 215-898-8214
Fax: 215-573-2133
Lab: 215-573-3645
BA (Biology)
University of Patras, Faculty of Biology, Greece, 1998.
PhD (Genetics and Developmental Biology)
Max-Planck Institute for Biophysical Chemistry, Department Molecular Developmental Biology, Goettingen, Germany, 2002.
Permanent link
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Description of Research Expertise

Keywords: muscle stem cells, muscle disorders, aging, telomeres, NF-kB signaling, muscle regeneration, stem cell regulation, muscular dystrophy, cardiomyopathy, mitochondria, oxidative stress, M2 macrophages, muscle atrophy, muscle wasting.

Selected Publications

Tichy ED, Ma N., Sidibe D., Loro E., Kocan J., Chen DZ., Khurana TS., Hasty P., Mourkioti F.: Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Cell Reports. Cell Press, 35(6), May 2021.

Lutian Yao, Elisia D. Tichy, Leilei Zhong, Sarthak Mohanty, Luqiang Wang, Emily Ai, Shuying Yang, Foteini Mourkioti1*, Ling Qin *: Gli1 defines a subset of fibroadipogenic progenitors that promote skeletal muscle regeneration with less fat accumulation. Journal of Bone and Mineral Research 36(6): 1159-1173, February 2021.

Suradip Das,, Kevin D. Browne, Franco A. Laimo, Joseph C. Maggiore, Melanie C. Hilman, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S. Ali, Foteini Mourkioti, D. Kacy Cullen: Pre-Innervated Tissue Engineeried Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss. Communications Biology-Nature 3(1), June 25 2020 Notes: doi: 10.1038/s42003-020-1056-4.

Sangkyun Cho, Manasvita Vashisth, Amal Abbas, Stephanie Majkut1,, Kenneth Vogel, Yuntao Xia, Irena Ivanovska, Jerome Irianto, Manorama Tewari, Elisia Tichy, Foteini Mourkioti, Hsin-Yao Tang, Roger A. Greenberg, Benjamin Prosser, and Dennis E. Discher : Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest Developmental Cell 49(6): 920-935, May 2019.

Alexandra Stanley, Su-jin Heo, Robert L. Mauck, Foteini Mourkioti and Eileen M. Shore: Elevated BMP and mechanical signaling through YAP1/RhoA poises FOP mesenchymal progenitors for osteogenesis. Journal of Bone and Mineral Research 34(10): 1894-1909, May 2019.

Haupt J., Stanley A., McLeod, CM., Cosgrove BD., Culbert, AL., Wang L., Mourkioti F., Mauck RL., Shore EM.: ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification. Molecular Biology of the Cell 30(1): 17-29, January 2019.

Elisia D Tichy, David K. Sidibe, Christopher D. Greer, Nicholas M. Oyster, Panteleimon Rompolas, Nadia A. Rosenthal, Helen M. Blau and Foteini Mourkioti: A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors in muscle stem cells. Skeletal Muscle 8, September 2018 Notes: doi: 10.1186/s13395-018-0169-7.

Ho PP, Lahey LJ, Mourkioti F, Kraft PE, Filareto A, Brandt M, Magnusson KEG, Finn EE, Chamberlain JS, Robinson WH, Blau HM, Steinman L.: Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy. Proc Natl Acad Sci U S A. 115(39): E9182-E9191, September 2018.

Sharifi-Sanjani. M., Oyster, N.M., Tichy, E.D., Bedi, K.C., Harel, O., Margulies, K.B., Mourkioti, F.: Cardiomyocyte-specific telomere shortening is a distinct signature of heart failure in humans Journal of American Heart Association 7(6): 1855-1870, Sept 2017 Notes: This work was highlighted in Penn Medicine News at: https://www.pennmedicine.org/news/news-releases/2017/september/penn-researchers-closer-to-uncovering-a-new-feature-in-heart-failure

Tichy, E.D., Sidibe, D.K., Tierney, M.T., Stec, M.J., Sharifi-Sanjani, M., Hosalkar, H., Mubarak, S., Johnson, F.B., Sacco, A., Mourkioti, F.: Single Stem Cell Imaging and Analysis Reveals Telomere Length Differences in Diseased Human and Mouse Skeletal Muscles Stem Cell Reports 9(4): 1328-1341, Sept 2017.

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Last updated: 09/19/2021
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