Shannon E O'reilly

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Shannon E O'Reilly, Ph.D.

Assistant Professor of Clinical Radiation Oncology
Department: Radiation Oncology

Contact information
3400 Civic Center Boulevard
Perelman Center for Advanced Medicine
Philadelphia, PA 19104
B.S. (Nuclear Engineering)
University of Florida, 2011.
M.S. (Biomedical Engineering, Medical Physics Concentration)
University of Florida, 2013.
Ph.D. (Biomedical Engineering, Medical Physics Concentration)
University of Florida, 2016.
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Description of Clinical Expertise

Proton Therapy, HDR Brachytherapy, Thoracic Radiotherapy

Description of Research Expertise

4DCT ventilation, Monte Carlo dosimetry, and reducing radiation-induced toxicities

Selected Publications

N Yegya-Raman, TP Kegelman, SH Lee, MJ Kallan, KN Kim, J Natarajan, MP Deek, W Zou, SE O'Reilly, Z Zhang, W Levin, K Cengel, G Kao, RB Cohen, LL Sun, CJ Langer, C Aggarwal, AP Singh, R O'Quinn, B Ky, A Apte, J Deasy, Y Xiao, AT Berman, SK Jabbour, SJ Feigenberg : Death without progression as an endpoint to describe cardiac radiation effects in locally advanced non-small cell lung cancer. Clin Transl Radiat Oncol Jan 2023.

O’Reilly S, Jain V, Cheng C, Huang Q, Teo BK, Yin L, Zhang M, Diffenderfer E, Li T, Levin W, Xiao Y, Dong L, Feigenberg S, Berman A, Zou W: Dose to Highly Functional Ventilation Zones Improves Prediction of Radiation Pneumonitis for Proton and Photon Lung Cancer Radiotherapy. Int J Radiat Oncol Biol Phys 107(1): 79-87, May 2020.

Yeom Y, Griffin K, Mille M, Lee C, O'Reilly S, Dong L, Jung JW, Lee C.: Fetal dose from proton pencil beam scanning craniospinal irradiation during pregnancy: A Monte Carlo study. Phys Med Biol 67(3), January 2022.

Kassaee A, Cheng C, Yin L, Zou W, Li T, Lin A, Swisher-McClure S, Lukens JN, Lustig RA, O’Reilly S, Dong L, Hytonen R, Teo BK: Dual-Energy Computed Tomography Proton-Dose Calculation with Scripting and Modified Hounsfield Units. Int J Part Ther 8(1), June 2021.

Yoon SW, Freedman GM, Taunk NK, Anamalayil S, Dong L, Hubley E, Kennedy C, O’Reilly S, Teo BK, Zou W, Metz JM, Li T: Per-Fraction Positional and Dosimetric Performance of Prone Breast Tangential Radiotherapy on Halcyon™ Linear Accelerator Assessed with Daily Rapid Kilo-voltage Cone Beam Computed Tomography: A Single-Institution Pilot Study. Radiat Oncol November 2020.

Harris W, Zou W, Cheng C, Jain V, Teo BK, Dong, L, Feigenberg SJ, Berman AT, Levin WP, Cengel K, O'Reilly SE: Higher dose volumes may be better for evaluating radiation pneumonitis in lung proton therapy patients compared to traditional photon-based dose constraints. Advances in Radiation Oncology 5(5), September 2020.

Hague C, Aznar M, Li T, O’Reilly S, Dong L, Fotouhi-Ghiam A, Lee LW, Lowe M, Lukens JN, McPartlin A, Slevin N, Swisher-McClure S, Thomson D, van Herk M, West C, Zou W, Lin A, Teo BK: Inter-fraction Robustness of Intensity-Modulated Proton Therapy in the Treatment of Post-operative Oropharyngeal Squamous Cell Carcinomas. Br J Radiol 93(1107), March 2020 Notes: doi: 10.1259/bjr.20190638.

Jain V, Irmen P, O’Reilly S, Lin L, Vogel J, Lin A: Predicted Secondary Malignancies Following Proton Versus Photon Radiation for Oropharyngeal Cancers. Int J Part Ther April 2020.

Vogel J, Grewal A, O’Reilly S, Lustig RA, Kurtz G, Minturn J, Shah A, Waanders A, Belasco J, Cole K, Fisher M, Phillips P, Balamuth N, Storm PJ, Hill-Kayser C: Risk of Brainstem Necrosis in Pediatric Patients with Central Nervous System Malignancies After Pencil Beam Scanning Proton Therapy. Acta Oncologica 58(12), December 2019.

Lalonde A, Xie Y, Burgdorf B, O'Reilly S, Ingram WS, Yin L, Zou W, Dong L, Bouchard H, Teo K: Influence of intravenous contrast agent on dose calculation in proton therapy using dual energy CT. Phys Med Biol 64(12), June 2019 Notes: doi: 10.1088/1361-6560/ab1e9d.

Khamwan K, O'Reilly SE, Plyku D, Goodkind A, Josefsson, Cao X, Fahey FH, Treves ST, Bolch WE, Sgouros G: Re-evaluation of Pediatric 18F-FDG Dosimetry: Cristy-Eckerman versus UF/NCI Hybrid Computational Phantoms. Phys Med Biol 63(16), Aug 2018 Notes: doi: 10.1088/1361-6560/aad47a

Li Y, O'Reilly S, Plyku D, Treves ST, Du Y, Fahey F, Cao X, Jha A, Sgouros G, Bolch WE, Frey EC: A projection image database to investigate factors affecting image quality in weight-based dosing: application to pediatric renal SPECT Phys Med Biol 63(14), July 2018 Notes: doi: 10.1088/1361-6560/aacbf0.

Zheng S, Jabbour SK, O'Reilly S, Lu J, Dong L, Xiao Y, Yue N, Wang F, Zou W: Automated Information Extraction on Treatment and Prognosis for Non-Small Cell Lung Cancer Radiotherapy Patients. JMIR Med Inform 6(1): e8, Feb 2018 Notes: doi: 10.2196/medinform.8662

Fehey F, Goodkind A, Plyku D, Khamwan K, O'Reilly SE, Cao X, Frey E, Li Y, Bolch WE, Sgouros G, Treves T: Dose Estimation in Pediatric Nuclear Medicine. Sem Nucl Med 47(2): 118-125, Mar 2017 Notes: doi: 10.1053/j.semnuclmed.2016.10.006

O'Reilly S, Li W, Frey E, Sgouros G, Plyku D, Bolch WE: A risk index for pediatric patients undergoing diagnostic imaging with 99mTc-dimercaptosuccinic acid that accounts for body habitus. Phys Med Biol 61(6): 2319-32, Mar 2016 Notes: doi: 10.1088/0031-9155/61/6/2319

O'Reilly S, Sinclair L, Maynard M, Wayson M, Didier R, Bolch WE: An image-based skeletal dosimetry model for the ICRP reference adult female - internal electron sources. Phys Med Biol 61(24): 8794-8824, December 2016.

Khamwan K, Plyku D, O'Reilly S, Fehey F, Treves T, Bolch WE, Sgouros G: Pharmacokinetic modeling of 18F-fluorodeoxyglucose (FDG) for premature infants, and newborns through 5-years old. EJNMMI Res 6(1): 28, Dec 2016 Notes: doi: 10.1186/s13550-016-0179-6

Geyer AM, Schwartz BC, O'Reilly SE, Hobbs RF, Sgouros G, Bolch WE: Depth-dependent concentrations of hematopoietic stem cells in the adult skeleton: Implications for active marrow dosimetry. Med Phys Page: 747-61, Feb 2017 Notes: doi: 10.1002/mp.12056

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Last updated: 11/29/2023
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