Michael Silverman
Michael Silverman, MD, PhD
Associate Professor of Pediatrics (Infectious Diseases)
Associate Director, Pediatric Infectious Disease Fellowship, Children's Hospital of Philadelphia
Director, Immunology, Microbial Medicine Center, Children's Hospital of Philadelphia
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Division of Infectious Diseases
3615 Civic Center Blvd
Philadelphia, PA 19104
Division of Infectious Diseases
3615 Civic Center Blvd
Philadelphia, PA 19104
Email:
silvermam1@email.chop.edu
silvermam1@email.chop.edu
Graduate Group Affiliations
Education
BS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.
Permanent linkBS (Biology)
Cornell University, 1998.
MD, PhD (Medicine and Immunology)
University of Pennsylvania School of Medicine, 2007.
Description of Clinical Expertise
Immunocompromised patientsDescription of Research Expertise
Microbiome, Immunology, HLA, MHC, antibiotics, intestinal immune system, autoimmune (type I) diabetes, IgA deficiency, Early life immune system developmentSelected Publications
Semon A, Manzer HS, Keenan O, Zhou TH, Tiffany C, She Q, Knight M, Weiss AS, Donohoe K, Morrow BT, Glover RC, Kovalik ME, Tanes C, Bittinger K, Zemel BS, Wu GD, Silverman MA, Gerber JS, Cano RodrÃguez R, Lacy DB, Karakasheva TA, Alameh MG, Weissman D, Schultz-Cherry SL, Rosch JW, Planet PJ, Moustafa AM, Furth EE, Abt MC, Kelsen JR, Conrad MA, Hamilton KE, Zackular JP.: Early-life colonization with Clostridioides difficile remodels the developing gut. Science September 2026.Christine M. Tin1, Bianca Cordazzo Vargas, Darryl A. Abbott, Aditi Lohar, Tiffany C. Taylor, Ivan Valishev, Sarah Weinshel, Vung Lian, Matthew Butoryak, Michael A. Silverman, Liat Shenhav, William H. DePas, Timothy W. Hand: Single-cell quantitation of the microbiota by flow cytometry: MicFLY. Cell Host and Microbe June 2026.
Omry Koren, Maria Carmen Collado, Benoit Chassaing, Michael A Silverman, Liza Konnikova: Microbial metabolites at the front line: Orchestrating gastrointestinal and systemic barrier immunity across the lifespan. Cell Reports June 2026.
Maryam abedi, Priyandarshini Rai, Yeqiao Zhou, Chengyang Liu, Isabelle Johnson, Aditi Chandra, Maria Fasolino, Susan Rostami, Wei Wang, Zaw Min, Yinjing LI, Ming Yu, Atishay Jay, Vung Lian, Michael Silverman, Klaus Kaestner, Ali Naji, Robert B. Faryabi, Golnaz Vahedi: Joint profiling of gene expression and chromatin accessibility in the pancreatic lymph nodes and spleens in human type 1 diabetes. Science Immunology November 2025 Notes: accepted for publication.
Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. Microbiome October 2025.
Michael Silverman and Kathryn Knoop: Setting the table for immune tolerance. Science 389(6761): 684-685, August 2025.
Shenhav L, Azad M, and Silverman MA.: Human Milk as a Microbial Pacemaker. Cell Host and Microbe 33(6): 762-765, June 2025.
Natalie A Trigg, Simon K Zhou, Jordan C Harris, Madeline N Lamonica, Molly A Nelson, Michael A Silverman, Taku Kambayashi, Colin C Conine: A lack of commensal microbiota influences the male reproductive tract intergenerationally in mice. Reproduction 169(4): e240204, March 2025.
Jean-Bernard Lubin, Paul J. Planet, Michael A. Silverman: Microbial succession at weaning is guided by microbial metabolism of host glycans. bioRxiv Page: doi: 10.1101/2025.02.20.639370, February 2025.
Siqi Linsey Zhang, Carolyn M McGann, Tereza Duranova, Jonathan Strysko, Andrew P Steenhoff, Alemayehu Gezmu, Britt Nakstad, Tonya Arscott-Mills, One Bayani, Banno Moorad, Nametso Tlhako, Melissa Richard-Greenblatt, Paul J Planet, Susan E Coffin, Michael A Silverman: Maternal and neonatal IgG against Klebsiella pneumoniae are associated with lower risk of neonatal sepsis: a case-control study of hospitalized neonates in Botswana. PLOS Global Public Health 4(12): e0003350, December 2024.