Sarah Henrickson
Sarah Henrickson, M.D., Ph.D.
Assistant Professor of Pediatrics (Allergy/Immunology)
Department: Pediatrics
Contact information
Children's Hospital of Philadelphia
Allergy Immunology Division
3615 Civic Center Blvd
Philadelphia, PA 19104
Allergy Immunology Division
3615 Civic Center Blvd
Philadelphia, PA 19104
Email:
henricksons@chop.edu
henricksons@chop.edu
Graduate Group Affiliations
Publications
Education:
BA
Harvard University, 2001.
Ph.D.
Harvard Medical School, 2008.
M.D.
Harvard Medical School, 2011.
Permanent linkBA
Harvard University, 2001.
Ph.D.
Harvard Medical School, 2008.
M.D.
Harvard Medical School, 2011.
Description of Clinical Expertise
Immune DeficiencyAsthma
Description of Research Expertise
Human ImmunologyImmune Dysregulation
Mouse models of disease
Primary Immune Deficiency
Asthma
Obesity
Selected Publications
Henrickson SE*, Manne S*, Dolfi DV, Mansfield KD, Parkhouse K, MIstry RD, Alpern ER, Hensley SE, Sullivan KE, Coffin SE and EJ Wherry (* = co-first authors): Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection. Cell Reports 22(2): 411-426, January 2018.Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, Potter SS, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JL, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen YW, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HM, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding YY, Kim MS, Xing Y, Kong SW, Bönnemann CG, Mandl KD and PS White: The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Dev. Cell S1534-5807(19): 30178, March 2019.
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN and UH von Andrian: Antigen Availability Determines CD8+ T Cell-Dendritic Cell Interaction Kinetics and Memory Fate Decisions. Immunity 39(3): 496-507, September 2013.
Ruffner MA, Henrickson SE, Chilutti M, Grundmeier R, Spergel JM and TF Brown-Whitehorn: Improving allergy office scheduling increases patient follow up and reduces asthma readmission after pediatric asthma hospitalization. Ann. Allergy Asthma Immunol. 121(5): 561-567, Nov 2018.
Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Tan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EWY, Blessing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS and RS Abraham: Use of Genetic Testing for Primary Immunodeficiency Patients. J. Clin. Immunol 38(3): 320-329, Apr 2018.
Henrickson SE, Mempel TR, Mazo IB, Artyomov MN, Zheng H, Liu B, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK and UH von Andrian: T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat. Immunol. 9(3): 282-91, Mar 2008.
Mempel T, Henrickson SE and UH von Andrian: T-cell priming by Dendritic cells in Lymph Nodes Occurs in Three Distinct Phases. Nature 427(6970): 154-59, Jan 2004 Notes: Highlighted by Thomson ISI as New Hot Paper in Immunology, March and November 2005; http://isi-topics.com/nhp/march-05-UlrichvonAndrian.html.
Keller MD, Pandey R, Li D, Glessner J, Tian L, Henrickson SE, Chinn IK, Monaco-Shawver, Heimall J, Hou C, Otieno FG, Jyonouchi S, Calabrese L, van Montfrans J, Orange JS and H Hakonarson.: Mutation in IRF2BP2 is responsible for a familial form of common variable immunodeficiency disorder. J. Allergy Clin. Immunol. 138(2): 544-50, March 2016.
Lawless D, Geier CB, Farmer JR, Lango HA, Thwaites D, Atschekzei F, Brown M, Buchbinder D, Burns SO, Butte MJ, Csomos K, Deevi SVV, Egner W, Ehl S, Eibl MM, Fadugba O, Foldvari Z, Green DM, Henrickson SE, Holland SM, John T, Klemann C, Kujjpers TW, Moreira F, Piller A, Rayner-Matthews P, Romberg ND, Sargur R, Schmidt RE, Schroder C, Schuetz C, Sharapova SO, Smith KGC, Sogkas G, Speckmann C, Stirrups K, Thrasher AJ, Wolf HM, Notarangelo LD, Anwar R, Boyes J, Ujhazi B, NIHR BioResource-Rare Disease Consortium, Thaventhiran, Walter JE and S Savic: Prevalence and clinical challenges among adult primary immunodeficiency patients with RAG deficiency. J. Allergy Clin. Immunol. 141(6): 2303, June 2018.
Henrickson S and D Altshuler: Risk and Return for the Clinician Scientist. Sci. Transl. Med. 4(135): doi: 10.1126, May 2012 Notes: online pub
Henrickson SE and JR Treat: Topical cidofovir for recalcitrant verrucae in SCID patients post hematopoetic stem cell transplant. Pediatric Dermatology 34(1): e24-e25, October 2017.
Henrickson SE, Walter JE, Quinn C, Kanakry JA, Bardakjian T, Dimitrova D, Ujhazi B, Csomos K, Bosticardo M, Dobbs K, Nasrallah M, Notarangelo LD, Holland SM and O Fadugba.: Adult-Onset Myopathy in a Patient with Hypomorphic RAG2 Mutations and Combined Immune Deficiency. J. Clin. Immunol. 38(6): 642-645, Aug 2018.