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Kyong-Mi Chang
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Professor of Medicine (Gastroenterology)
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Department: Medicine
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Graduate Group Affiliations
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- Cell and Molecular Biology 5c
- Immunology e
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Contact information
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Corporal Michael J. Crescenz VAMC &
3e University of Pennsylvania Perelman School of Medicine
37 3900 Woodland Avenue
Philadelphia, PA 19104
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3e University of Pennsylvania Perelman School of Medicine
37 3900 Woodland Avenue
Philadelphia, PA 19104
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Office: (215) 823-5893
49 Lab: (215) 823-5800 ext 6730
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49 Lab: (215) 823-5800 ext 6730
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Publications
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Links
b5 Search PubMed for articles
51 Cell and Molecular Biology graduate group faculty webpage.
7a Primary Work Website
78 Corporal Michael J. Crescenz VA Medical Center
be Penn Medicine Liver Diseases Program
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b5 Search PubMed for articles
51 Cell and Molecular Biology graduate group faculty webpage.
7a Primary Work Website
78 Corporal Michael J. Crescenz VA Medical Center
be Penn Medicine Liver Diseases Program
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Education:
21 9 A.B. 32 (Chemistry, Mathematics, and Fine Arts) c
2a Bryn Mawr College, 1983.
21 9 M.D. c
3c The Medical College of Pennsylvania, 1987.
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Permanent link21 9 A.B. 32 (Chemistry, Mathematics, and Fine Arts) c
2a Bryn Mawr College, 1983.
21 9 M.D. c
3c The Medical College of Pennsylvania, 1987.
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Description of Research Expertise
1fb Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection. As the PI of a VA Merit award using the VA's Million Veterans Program (MVP), Dr. Chang is also conducting population-based genomic analyses of cardiometabolic disorders including MASLD/NAFLD and liver disease progression to cirrhosis and HCC--in collaboration with other large national and international genomic cohorts.65
Description of Clinical Expertise
1ad Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic liver disease (e.g. HBV, HCV, MASLD). She founded and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012 and supervised fellows in the Fellows' GI/Hepatitis Clinic 2002-2024. She continues to see patients as an attending physician for GI/Liver Clinic to date.62
Description of Other Expertise
3a9 As the Associate Chief of Staff for Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC) since 2012, Dr. Chang leads the VA research program at the CMCVAMC with an administrative oversight for all of its VA-based and/or VA-funded research (e.g. via VA Career Development Award, Merit Review, Cooperative Studies Program and MVP research). Dr. Chang has also been actively engaged in VA research at the national level, serving as the Acting Chief R&D Officer in Washington DC (Dec 2015 - Mar 2016), member of the national Executive Committee for the VA's Million Veteran Program (MVP) ( and a member of the national ACOS/R&D Council (2024-present). She is committed to mentoring VA-based researchers both locally and nationally, and has built a cadre of VA Career Development Awardees at the CMCVAMC since starting her leadership role as ACOS/R&D.e 29
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25b Mureddu M, Pelusi S, Jamialahmadi O, Vujkovic M, Miano L, Eidgah Torghabehei H, Ronzoni L, Malvestiti F, Saracino M, Periti G, Moretti V, Teerlink CC, Lynch JA, Tsao PS, Johnson JP, La Mura V, Dilena R, Alqahtani SA, Cherubini A, Russo FP, D'Ambrosio R, Fraquelli M, Petta S, Miele L, Vespasiani-Gentilucci U, Bugianesi E, Mancina RM, Parini P, Prati D, Chang KM, Schneider CV, Romeo S, Valenti LV.: Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma. J Clin Invest Feb 2026.
1af Sideris K, Nelson TJ, Brinker L, Gao A, Tcheandjieu C, Kyriakopoulos CP, Berlowitz D, Hull L, Ferraro JP, Agiri FY, Pridgen KM, Roblin S, Joseph J, Damrauer SM, Chang KM, Teerlink CC, Stehlik J, Carter S, Lynch JA.: Systemic Manifestations and Mortality Risk in Transthyretin V142I Variant Carriers: A Million Veteran Program Analysis. JACC CardioOncol 2026.
188 Bermudez F, Shakt G, Bowles A, Alba P, Dinatale T, Chang KM, Tsao PS, Lynch J, Dochtermann D, Pyarajan S, Small A, Levin MG, Damrauer SM.: Multipopulation Genome-Wide Association Study Identifies Novel Loci for Bicuspid Aortic Valve and Reveals Shared Genetic Architecture With Aortopathies. Circ Genom Precis Med 2026.
1d1 Sideris K, Nelson TJ, Brinker L, Gao A, Tcheandjieu C, Kyriakopoulos CP, Berlowitz D, Hull L, Ferraro JP, Agiri FY, Pridgen KM, Roblin S, Joseph J, Levin MG, Damrauer SM, Chang KM, Teerlink CC, Stehlik J, Carter S, Lynch JA.: Risk of Systemic Manifestations in Homozygous Carriers of the Transthyretin V142I Variant: A Million Veteran Program Analysis. J Am Heart Assoc 14: e044923, Dec 2025.
1bf Maamari DJ, Biddinger KJ, Jurgens SJ, Rämö JT, Gaziano L, Zheng A, Challa SP, Hayes D, Gongora CA, Choi SH, Chang KM, Tsao PS, Arany Z, Thavendiranathan P, Huffman JE, Fahed AC, Sarma AA, Neilan TG, Khera AV, Ellinor PT, Aragam KG.: Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. JAMA Cardiol 10: 1138-1146, Nov 2025.
424 Guo B, Cai Y, Kim D, Smit RAJ, Wang Z, Iyer KR, Hilliard AT, Haessler J, Tao R, Broadaway KA, Wang Y, Pozdeyev N, Stæger FF, Yang C, Vanderwerff B, Patki AD, Stalbow L, Lin M, Rafaels N, Shortt J, Wiley L, Stanislawski M, Pattee J, Davis L, Straub PS, Shuey MM, Cox NJ, Lee NR, Jørgensen ME, Bjerregaard P, Larsen C, Hansen T, Moltke I, Meigs JB, Stram DO, Yin X, Zhou X, Chang KM, Clarke SL, Guarischi-Sousa R, Lankester J, Tsao PS, Buyske S, Graff M, Raffield LM, Sun Q, Wilkens LR, Carlson CS, Easton CB, Liu S, Manson JE, Marchand LL, Haiman CA, Mohlke KL, Gordon-Larsen P, Albrechtsen A, Boehnke M, Rich SS, Manichaikul A, Rotter JI, Yousri NA, Irvin RM; biobank at the Colorado Center for Personalized Medicine (CCPM); VA Million Veteran Program (MVP); Gignoux C, North KE, Loos RJF, Assimes TL, Peters U, Kooperberg C, Raghavan S, Highland HM, Darst BF.: Polygenic risk score for type 2 diabetes shows context-dependent effects across populations. Nat Commun 16: 8632, Oct 2025.
fb Callans LE, Ivey KL, Chang KM, Kaplan DE; VA Million Veteran Program.: Diet composition impacts the natural history of steatotic liver disease. Hepatol Commun 9: e0754, Jun 2025.
18a Adkar SS, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D.: Dissecting the Genetic Architecture of Intracranial Aneurysms. Circ Genom Precis Med Jun 2025.
1d7 Chanfreau-Coffinier C, Friede KA, Plomondon ME, Lee KM, Lu Z, Dinatale T, DuVall SL, Vassy JL, Waldo SW, Cleator JH, Maddox TM, Rader DJ, Assimes TL, Damrauer SM, Tsao PS, Chang KM, Voora D, Lynch JA, Giri J; VA Million Veteran Program; Tuteja S.: CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program. Clin Pharmacol Ther Jun 2025.
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Selected Publications
158 Wendland ZD, Teerlink CC, Pridgen KM, Lo S, Sayed C, van Straalen KR, Tcheandjieu C, Tsao PS, Chang KM, Li Y, Mohlke KL, Sun Q, Lynch JA, Goldfarb N.: A genome-wide association study of hidradenitis suppurativa from the VA's Million Veteran Program. Dermatology Feb 2026.25b Mureddu M, Pelusi S, Jamialahmadi O, Vujkovic M, Miano L, Eidgah Torghabehei H, Ronzoni L, Malvestiti F, Saracino M, Periti G, Moretti V, Teerlink CC, Lynch JA, Tsao PS, Johnson JP, La Mura V, Dilena R, Alqahtani SA, Cherubini A, Russo FP, D'Ambrosio R, Fraquelli M, Petta S, Miele L, Vespasiani-Gentilucci U, Bugianesi E, Mancina RM, Parini P, Prati D, Chang KM, Schneider CV, Romeo S, Valenti LV.: Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma. J Clin Invest Feb 2026.
1af Sideris K, Nelson TJ, Brinker L, Gao A, Tcheandjieu C, Kyriakopoulos CP, Berlowitz D, Hull L, Ferraro JP, Agiri FY, Pridgen KM, Roblin S, Joseph J, Damrauer SM, Chang KM, Teerlink CC, Stehlik J, Carter S, Lynch JA.: Systemic Manifestations and Mortality Risk in Transthyretin V142I Variant Carriers: A Million Veteran Program Analysis. JACC CardioOncol 2026.
188 Bermudez F, Shakt G, Bowles A, Alba P, Dinatale T, Chang KM, Tsao PS, Lynch J, Dochtermann D, Pyarajan S, Small A, Levin MG, Damrauer SM.: Multipopulation Genome-Wide Association Study Identifies Novel Loci for Bicuspid Aortic Valve and Reveals Shared Genetic Architecture With Aortopathies. Circ Genom Precis Med 2026.
1d1 Sideris K, Nelson TJ, Brinker L, Gao A, Tcheandjieu C, Kyriakopoulos CP, Berlowitz D, Hull L, Ferraro JP, Agiri FY, Pridgen KM, Roblin S, Joseph J, Levin MG, Damrauer SM, Chang KM, Teerlink CC, Stehlik J, Carter S, Lynch JA.: Risk of Systemic Manifestations in Homozygous Carriers of the Transthyretin V142I Variant: A Million Veteran Program Analysis. J Am Heart Assoc 14: e044923, Dec 2025.
1bf Maamari DJ, Biddinger KJ, Jurgens SJ, Rämö JT, Gaziano L, Zheng A, Challa SP, Hayes D, Gongora CA, Choi SH, Chang KM, Tsao PS, Arany Z, Thavendiranathan P, Huffman JE, Fahed AC, Sarma AA, Neilan TG, Khera AV, Ellinor PT, Aragam KG.: Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. JAMA Cardiol 10: 1138-1146, Nov 2025.
424 Guo B, Cai Y, Kim D, Smit RAJ, Wang Z, Iyer KR, Hilliard AT, Haessler J, Tao R, Broadaway KA, Wang Y, Pozdeyev N, Stæger FF, Yang C, Vanderwerff B, Patki AD, Stalbow L, Lin M, Rafaels N, Shortt J, Wiley L, Stanislawski M, Pattee J, Davis L, Straub PS, Shuey MM, Cox NJ, Lee NR, Jørgensen ME, Bjerregaard P, Larsen C, Hansen T, Moltke I, Meigs JB, Stram DO, Yin X, Zhou X, Chang KM, Clarke SL, Guarischi-Sousa R, Lankester J, Tsao PS, Buyske S, Graff M, Raffield LM, Sun Q, Wilkens LR, Carlson CS, Easton CB, Liu S, Manson JE, Marchand LL, Haiman CA, Mohlke KL, Gordon-Larsen P, Albrechtsen A, Boehnke M, Rich SS, Manichaikul A, Rotter JI, Yousri NA, Irvin RM; biobank at the Colorado Center for Personalized Medicine (CCPM); VA Million Veteran Program (MVP); Gignoux C, North KE, Loos RJF, Assimes TL, Peters U, Kooperberg C, Raghavan S, Highland HM, Darst BF.: Polygenic risk score for type 2 diabetes shows context-dependent effects across populations. Nat Commun 16: 8632, Oct 2025.
fb Callans LE, Ivey KL, Chang KM, Kaplan DE; VA Million Veteran Program.: Diet composition impacts the natural history of steatotic liver disease. Hepatol Commun 9: e0754, Jun 2025.
18a Adkar SS, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D.: Dissecting the Genetic Architecture of Intracranial Aneurysms. Circ Genom Precis Med Jun 2025.
1d7 Chanfreau-Coffinier C, Friede KA, Plomondon ME, Lee KM, Lu Z, Dinatale T, DuVall SL, Vassy JL, Waldo SW, Cleator JH, Maddox TM, Rader DJ, Assimes TL, Damrauer SM, Tsao PS, Chang KM, Voora D, Lynch JA, Giri J; VA Million Veteran Program; Tuteja S.: CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program. Clin Pharmacol Ther Jun 2025.
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