Perelman School of Medicine at the University of Pennsylvania

Cameron J. Koch

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Cameron J. Koch, Ph.D.

Professor of Radiation Biology in Radiation Oncology
Department: Radiation Oncology

Contact information
185 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6072
Office: 215-898-0073
Fax: 215-898-0090
University of Waterloo, Ontario, Canada, 1968.
University of Waterloo, Ontario, Canada, 1969.
University of Waterloo, Ontario, Canada, 1972.
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Description of Research Expertise

Measurement of radioresistant hypoxic tumor cells in vivo using:
•immunohistochemistry and/or flow cytometry
•non-invasive imaging
•Quantification of tissue pO2
•Control and measurement of oxygen concentration and thiols
•Quantitative Fluorescence Microscopy
•Oxidative damage (primarily sulfydryl to disulfide) of DNA repair systems
•Effects of oxygen and oxygen radicals in biological or biochemical systems
•Development of fluorine-based PET imaging methods
•Automated chemical synthesis
•Mechanisms of action of radiation sensitizing and radiation protecting agents (survival or DNA damage)
•Models for competitive reactions of radiation modifying agents
•Metabolism of thiols and nitroheterocyclics (including cytotoxicity)
•Measurement of intracellular drug concentrations

Selected Publications

Chang Q1, Ornatsky OI, Koch CJ, Chaudary N, Marie-Egyptienne DT, Hill RP, Tanner SD, Hedley DW.: Single-cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry. Int J Cancer. Jul 10 2014.

Regter S, Hedayati M, Zhang Y, Zhou H, Dalrymple S, Koch CJ, Isaacs JT, DeWeese TL: Androgen withdrawal fails to induce detectable tissue hypoxia in the rat prostate. Prostate. 74(8): 805-10, Jun 2014.

Sayler, E, Dolney, D, Avery, S, Koch, C: Shielding considerations for the small animal radiation research platform (SARRP). Health Phys. 104: 471-80, 2013.

Koch CJ, Jenkins WT, Jenkins KW, Yang XY, Shuman AL, Pickup S, Riehl1 CR, Paudya R, Poptani H, Evans SM: Mechanisms of Blood Flow and Hypoxia Production in Rat 9L Epigastric Tumors. Tumor Microenvironment and Therapy 1(1): 1-13, Dec 2012.

Lin LL, Silvoniemi A, Stubbs JB, Rengan R, Suilamo S, Solin O, Divgi C, Eskola O, Sorger JM, Stabin MG, Kachur A, Hahn SM, Grönroos TJ, Forsback S, Evans SM, Koch CJ, Minn H: Radiation dosimetry and biodistribution of the hypoxia tracer ¹⁸F-EF5 in oncologic patients. Cancer Biother Radiopharm. 27(7): 412-9, Sep 2012.

Evans SM, Koch CJ: Re: Devic et al. (Int J Radiat Oncol Biol Phys 2010;78:1555-1562). Int J Radiat Oncol Biol Phys. 81(3): 902; author reply 902-3, Nov 2011.

Koch CJ, Evans SM: In regard to Brown et al. (Int J Radiat Oncol Biol Phys 2010;78:323-327). Int J Radiat Oncol Biol Phys. 80(5): 1604-5; author reply 1605, Aug 2011.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Dicello JF, Little JB: Sequentially-induced responses define tumour cell radiosensitivity. Int J Radiat Biol. 87(6): 628-43, Jun 2011.

Marotta D1, Karar J, Jenkins WT, Kumanova M, Jenkins KW, Tobias JW, Baldwin D, Hatzigeorgiou A, Alexiou P, Evans SM, Alarcon R, Maity A, Koch C, Koumenis C: In Vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection. Cancer Res. 71(3): 779-89, Feb 2011.

Koch CJ, Scheuermann JS, Divgi C, Judy KD, Kachur AV, Freifelder R, Reddin JS, Karp J, Stubbs JB, Hahn SM, Driesbaugh J, Smith D, Prendergast S, Evans SM: Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma. Eur J Nucl Med Mol Imaging. 37(11): 2048-59, Nov 2010.

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Last updated: 05/13/2015
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