Pathogenesis and experimental therapeutics of complement-mediated inflammatory, autoimmune and thrombotic microangipathic diseases
complement, gene targeting, mouse model, innate immunity, inflammation, autoimmunity, C3 glomerulonephritis (C3GN), hemolytic uremic syndrome (HUS), dense deposit disease (DDD), age-related macular degeneration (AMD).
My research is focused on complement-mediated inflammatory, autoimmune and thrombotic microagiopathic disorders. By creating gene targeted mice, we establish mouse models of human diseases to understand disease pathogenesis and to test novel anti-complement therapies. We are also interested in the interaction of complement with other innate immune pathways such as the Toll-like receptors and with the adaptive immune system. Our long term goal is to advance basic complement immunology and to help develop new therapies for complement-mediated human diseases.
ROTATION PROJECTS (Please inquire).
Dunkelberger, J.R. and Song, W.-C.: Complement and its role in innate and adaptive immune responses Cell Res. 20: 34-50, 2010.
Kimura, Y., Zhou, L., Miwa, T. and Song, W.-C. : Genetic and therapeutic targeting of properdin prevents complement-mediated tissue injury.
J. Clin Invest. 120(10): 3545-3554, 2010.
Fang, C., Miwa, T. and Song, W.-C. : Decay-accelerating factor regulates T cell immunity in the context of inflammation by influencing co-stimulatory molecule expression on antigen-presenting cells. Blood. 118(4): 1008-1014, 2011.
Dunkelberger, J., Zhou, L., Miwa, T. and Song, W.-C. : C5aR expression in a novel GFP reporter gene knock-in mouse: implications for the mechanism of action of C5aR signaling in T cell immunity. J. Immunol 188(8): 4032-4042, 2012.
Miwa, T., Zhou, L., Maldonado, M. A., Eisenberg, R. A. and Song, W.-C. : Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice. J. Immunol 189(11): 5434-5441, 2012.
Lesher, A. M., Zhou, L., Kimura, Y., Sato,S., Gullipalli, D., Ruseva, M. M., Pickering, M.C., Herbert, A. P., Barlow, P., Skerka, C., Zipfel, P., Miwa, T., Tung, K. S. and Song, W.-C.: Lethal C3 glomerulonephritis resembling human dense deposit disease caused by combined fH C-terminal mutation and properdin deficiency in mice. J. Am. Soc. Nephrol. 24(1): 53-65, 2013.
Ruseva, M. M., Vernon, K. A., Lesher, A. M., Schwaeble, W. J., Ali, Y. M., Botto, M., Cook, H. T., Song, W.-C., Stover, C. and Pickering, M. C. : Properdin deficiency exacerbates C3 glomerulopathy in factor H-deficient mice. J. Am. Soc. Nephrol. 24(1): 43-52, 2013.
Barata, L., Miwa, T., Sato, S., Kim, D. D., Mohammed, I. and Song, W.-C. : Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases fH-dependent resistance of peripheral platelets to complement attack. J. Immunol 190(6): 2886-2895, 2013.
Miwa, T., Sato, S., Gullipalli, D., Nangaku, M and Song, W.-C. : Blocking properdin, the alternative pathway complement and anaphylatoxin receptors ameliorates renal ischemia reperfusion injury in decay-accelerating factor and CD59 double knockout mice. J. Immunol 190(7): 3552-3559, 2013.
Lesher, A. M., Nilsson, B. and Song, W.-C.: Properdin in Complement Activation and Tissue Injury. Mol Immunol.
[Epub ahead of print], June 2013.
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Last updated: 07/15/2013
The Trustees of the University of Pennsylvania