Publications

Arany lab has produced over 150 publications in journals such as Nature, Cell, Science, New England Journal of Medicine, Journal of American College of Cardiology, JAMA Cardiology, Cell Metabolism and others.  

A full list of publications can be found on PubMed or on Google Scholar Profile.    

 

Highlighted Papers

Selected list of recent publications.    

 

  1. Baker DJ, Frommer LM, Uslu U, Patel KK, Zhu D, Engel NW, George JM, Zhao W, Kim SI, Sun L, Roselle C, Rommel PC, Young RM, Epstein JA, Hayat S, Arany Z, June CH. AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy. Cell. 2026 Jun 25;189(13):3871-3882.
  2. Vite A, Guo T, Bouhrira N, Eaton DM, Bedi KC Jr, Brady CF, Edwards JJ, Duric B, Uchida K, Olsen C, Dong L, Prosser BL, Arany Z, Margulies KB. Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes. Cell Rep. 2026 Jul 28;45(7):117577
  3. Tanosaki S, Zhang Y, Bedi K, Margulies K, Cox JE, Arany Z, Abel ED. Choice of cardioplegia influences metabolomics of human cardiac tissue. Proc Natl Acad Sci U S A. 2026 May 19;123(20)
  4. Agarwal S, Bankar A, Heo L, Mitra A, Chakraborty A, Liu L, Huang F, Swaminathan G, Auer N, Chelladurai P, Guardado ES, Matos J, Le C, West J, Suresh K, Nair R, Rabinovitch M, Morisseau C, Hammock BD, Wu J, Arany Z, Nicolls MR, de Jesus Perez V. CES1 deficiency is associated with metabolic reprograming and endothelial dysfunction in pulmonary arterial hypertension. Am J Respir Crit Care Med. 2026 Jun 1;212(6):1315-1329. 
  5. Zhao W, Zhu W, Thome T, Soaita I, Jung JW, Noji MC, Li J, Bai H, Xiao Y, Yang Y, Thorsheim C, Zhou W, Yang Y, Li K, Edwards JJ, Kuznetsov IA, Kim B, Baur JA, Arany Z. NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis. Cell Metab. 2026 Jul 7;38(7):1478-1496
  6. Guerraty MA, Verma SS, Ko YA, McQuillan MA, Conlon DM, Tobias JW, Levin MG, Haury W, Zheng F, Cherlin T, Zhang C, Judy R, Tishkoff SA, Damrauer SM, Arany Z, Rader DJ. Friend of GATA2 Variant Ser657Gly Is Associated With Coronary Microvascular Disease. Circ Genom Precis Med. 2026 Apr;19(2):e005342. 
  7. Yucel N, Marchiano S, Tchelepi E, Paterlini G, Kuznetsov IA, Li K, McAfee Q, Nimmagadda N, Ren A, Shi S, Grogan A, Kontrogianni-Konstantopoulos A, Murry C, Arany Z. Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease. JCI Insight. 2026 Feb 23;11(4):e185739. 
  8. McDermott-Roe C, Lv W, Shao Y, Hoshino A, Arany Z, Musunuru K. CRISPR/Cas9 Screens Implicate RARA and SPNS1 in Doxorubicin Cardiotoxicity. JACC CardioOncol. 2026 Feb;8(1):48-61. 
  9. Arany Z. New approach methodologies: Don't throw the baby out with the bathwater. Cell Metab. 2026 Mar 3;38(3):441-442. 
  10. Yang Y, Lewey J, Arany Z. Cardiovascular complications of pregnancy. J Clin Invest. 2026 Jan 2;136(1):e198808. doi: 10.1172/JCI198808. 
  11. Hesse M, Korzus D, Thaben K, Wagner N, Ergün S, Arany Z, Fleischmann BK. Pregnancy hormones increase cardiac capillary density via the PGC-1α/ERRα/VEGF pathway in cardiomyocytes. Front Cardiovasc Med. 2025 Oct 14;12:1688831
  12. Maamari DJ, Biddinger KJ, Jurgens SJ, Rämö JT, Gaziano L, Zheng A, Challa SP, Hayes D, Gongora CA, Choi SH, Chang KM, Tsao PS, Arany Z, Thavendiranathan P, Huffman JE, Fahed AC, Sarma AA, Neilan TG, Khera AV, Ellinor PT, Aragam KG. Polygenic Susceptibility in Peripartum, Alcohol-Induced, and Cancer Therapy-Related Cardiomyopathies. JAMA Cardiol. 2025 Nov 1;10(11):1138-1146. 
  13. Smood B, Aronowitz DI, Noji M, Shoffler C, Abbasian D, Petucci C, Fiock KL, Hefti M, Degani R, Melchior RW, Catalano M, Arany Z, Yudkoff M, Gaynor JW, Kilbaugh T, Mavroudis CD. Branched-Chain Amino Acids Accumulate and Glutamate Decreases in Cerebral Interstitial Fluid Following Cardiopulmonary Bypass in Neonatal Swine. Eur J Cardiothorac Surg. 2025 Oct 2;67(10):
  14. Khan AA, Fayad FH, Kim CW, Ataklte F, Has P, Nebipasagil A, Arany Z, Poppas A, Wu WC, Choudhary G, Imran TF. Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis. JACC Adv. 2025 Sep;4(9):102047. 
  15. Axsom J, Arany Z. What Do We Know of Human Fuel Use during Aerobic Exercise, and How Do We Know It? Physiology (Bethesda). 2026 Jan 1;41(1):0.. Epub 2025 Aug 5. 
  16. Kasden CM, Corzo MP, Greer CD, Singh T, Reyes R, Castillo A, Arany Z, Kozyak BW, Stedman HH. AAV-microutrophin gene therapy confers durable cardioprotection against pharmacologic and exercise-induced injury in the mdx mouse. Mol Ther. 2025 Oct 1;33(10):4834-4847.
  17. Rodríguez LR, Alysandratos KD, Katzen J, Murthy A, Roque Barboza W, Tomer Y, Bui S, Acín-Pérez R, Petcherski A, Minakin K, Carson P, Iyer S, Chavez K, Cooper CH, Babu A, Weiner AI, Vaughan AE, Arany Z, Shirihai OS, Kotton DN, Beers MF. Impaired AMPK control of alveolar epithelial cell metabolism promotes pulmonary fibrosis. JCI Insight. 2025 Jul 1;10(15)
  18. DePaolo J, Bornstein MR, Judy R, Abramowitz S, Verma SS, Levin MG, Biobank PM, Arany Z, Damrauer SM. Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations. PLoS Genet. 2025 Jun 13;21(6):e1011727. 
  19. Yang Y, Arany Z. Why the Diabetic Heart Is Fatty. Circ Res. 2025 Jun 6;136(12):1561-1563. 
  20. Bowman CE, Neinast MD, Kawakami R, Forelli N, Jang C, Patel J, Blair MC, Noji MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z. Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. Mol Metab. 2025 Jul;97:102165. 
  21. Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dikilitas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P; Penn Medicine Biobank; Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM. Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum. Nat Genet. 2025 Apr;57(4):829-838. 
  22. Berkowitz J, Sagaityte E, Khalid M, Lopez D, Mohebali D, Bello N, Arany Z, French K, Poppas A, Sabe M, Wu WC, Joseph J, Djousse L, Choudhary G, Imran TF. The association of heart rate with adverse outcomes and recurrent heart failure hospitalization in peripartum cardiomyopathy. Clin Res Cardiol. 2025 Oct;114(10):1358-1365.
  23. Talukdar M, Chmátal L, Mao L, Reichart D, Murashige DS, Skaletsky H, DeLaughter DM, Arany Z, Seidman JG, Seidman CE, Page DC. Genes of the Fatty Acid Oxidation Pathway are Upregulated in Female as Compared to Male Cardiomyocytes. Circulation. 2025 Feb 18;151(7):511-514. 
  24. Kim Y, Kim SW, Saul D, Neyazi M, Schmid M, Wakimoto H, Slaven N, Lee JH, Layton O, Wasson LK, Letendre JH, Xiao F, Ewoldt JK, Gkatzis K, Sommer P, Gobert B, Wiest-Daesslé N, McAfee Q, Singhal N, Lun M, Gorham JM, Arany Z, Sharma A, Toepfer CN, Oudit GY, Pu WT, Dickel DE, Pennacchio LA, Visel A, Chen CS, Seidman JG, Seidman CE. Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer. J Clin Invest. 2024 Dec 17;135(4):e183353. 
  25. Irizarry OC, Lewey J, McCallister C, Koelper NC, Arany Z, Levine LD. Subsequent pregnancies in peripartum cardiomyopathy: Patient-level differences and decision-making. Am Heart J Plus. 2024 Oct 11;47:100472. 
  26. Axsom J, TeSlaa T, Lee WD, Chu Q, Cowan A, Bornstein MR, Neinast MD, Bartman CR, Blair MC, Li K, Thorsheim C, Rabinowitz JD, Arany Z. Quantification of nutrient fluxes during acute exercise in mice. Cell Metab. 2024 Dec 3;36(12):2560-2579
  27. Forelli N, Eaton D, Patel J, Bowman CE, Kawakami R, Kuznetsov IA, Li K, Brady C, Bedi K, Yang Y, Koya K, Megill E, Kanter DS, Smith LG, Bowman GR, Snyder N, Edwards J, Margulies K, Arany Z. SGLT2 inhibitors activate pantothenate kinase in the human heart. bioRxiv [Preprint]. 2024 Jul 27:2024
  28. Zierath JR, van der Velden J, Javaheri A, Rosenzweig A, Muoio DM, Mulvihill EE, Martino TA, Rasheed A, Chen XW, Arany ZP. Translating metabolic and cardiovascular research into effective treatments: What's next? Cell. 2024 Jul 25;187(15):3880-3884. 
  29. Berger JH, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP. SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice. Circ Res. 2024 Aug 16;135(5):632-634. 
  30. Ohl L, Kuhs A, Pluck R, Durham E, Noji M, Philip ND, Arany Z, Ahrens-Nicklas RC. Partial suppression of BCAA catabolism as a potential therapy for BCKDK deficiency. Mol Genet Metab Rep. 2024 May 10;39:
  31. Roh JD, Castro C, Yu A, Rana S, Shahul S, Gray KJ, Honigberg MC, Ricke-Hoch M, Iwamoto Y, Yeri A, Kitchen R, Guerra JB, Hobson R, Chaudhari V, Chang B, Sarma A, Lerchenmüller C, Al Sayed ZR, Diaz Verdugo C, Xia P, Skarbianskis N, Zeisel A, Bauersachs J, Kirkland JL, Karumanchi SA, Gorcsan J 3rd, Sugahara M, Damp J, Hanley-Yanez K, Ellinor PT, Arany Z, McNamara DM; IPAC Investigators; Hilfiker-Kleiner D, Rosenzweig A. Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Sci Transl Med. 2024 Apr 17;16(743):
  32. Arany Z. Peripartum Cardiomyopathy. N Engl J Med. 2024 Jan 11;390(2):154-164. 

  33. McAfee Q, Caporizzo MA, Uchida K, Bedi KC Jr, Margulies KB, Arany Z, Prosser BL. Truncated titin protein in dilated cardiomyopathy incorporates into the sarcomere and transmits force. J Clin Invest. 2024 Jan 16;134(2)

  34. Roh JD, Castro C, Yu A, Rana S, Shahul S, Gray KJ, Honigberg MC, Ricke-Hoch M, Iwamoto Y, Yeri A, Kitchen R, Guerra JB, Hobson R, Chaudhari V, Chang B, Sarma A, Lerchenmüller C, Al Sayed ZR, Diaz Verdugo C, Xia P, Skarbianskis N, Zeisel A, Bauersachs J, Kirkland JL, Karumanchi SA, Gorcsan J 3rd, Sugahara M, Damp J, Hanley-Yanez K, Ellinor PT, Arany Z, McNamara DM; IPAC Investigators; Hilfiker-Kleiner D, Rosenzweig A. Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human. Sci Transl Med. 2024 Apr 17;16(743)

  35. Kim B, Zhao W, Tang SY, Levin MG, Ibrahim A, Yang Y, Roberts E, Lai L, Li J, Assoian RK, FitzGerald GA, Arany Z. Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation. J Clin Invest. 2023 Dec 15;133(24)

  36. Bornstein MR, Neinast MD, Zeng X, Chu Q, Axsom J, Thorsheim C, Li K, Blair MC, Rabinowitz JD, Arany Z. Comprehensive quantification of metabolic flux during acute cold stress in mice. Cell Metab. 2023 Nov 7;35(11):2077-2092.

  37. Baker DJ, Arany Z, Baur JA, Epstein JA, June CH. CAR T therapy beyond cancer: the evolution of a living drug. Nature. 2023 Jul;619(7971):707-715. 

  38. Minami Y, Hoshino A, Higuchi Y, Hamaguchi M, Kaneko Y, Kirita Y, Taminishi S, Nishiji T, Taruno A, Fukui M, Arany Z, Matoba S. Liver lipophagy ameliorates nonalcoholic steatohepatitis through extracellular lipid secretion. Nat Commun. 2023 Jul 13;14(1):4084. 

  39. Zhu X, Wang Y, Soaita I, Lee HW, Bae H, Boutagy N, Bostwick A, Zhang RM, Bowman C, Xu Y, Trefely S, Chen Y, Qin L, Sessa W, Tellides G, Jang C, Snyder NW, Yu L, Arany Z, Simons M. Acetate controls endothelial-to-mesenchymal transition. Cell Metab. 2023 Jul 11;35(7):1163-1178.

  40. Reza N, Packard E, Goli R, Chowns JL, Owens AT, Arany Z, Lewey J. Clinical Predictors of Referral for and Yield of Genetic Testing in Peripartum Cardiomyopathy. JACC Heart Fail. 2023 Sep;11(9):1278-1280. 

  41. Blair MC, Neinast MD, Jang C, Chu Q, Jung JW, Axsom J, Bornstein MR, Thorsheim C, Li K, Hoshino A, Yang S, Roth Flach RJ, Zhang BB, Rabinowitz JD, Arany Z. Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance. Nat Metab. 2023 Apr;5(4):589-606. 

  42. Hahn VS, Petucci C, Kim MS, Bedi KC Jr, Wang H, Mishra S, Koleini N, Yoo EJ, Margulies KB, Arany Z, Kelly DP, Kass DA, Sharma K. Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction. Circulation. 2023 Apr 11;147(15):1147-1161

  43. Guerraty M, Arany Z. Editorial commentary: A call for a unified view of coronary microvascular disease. Trends Cardiovasc Med. 2024 Apr;34(3):145-147. 

  44. Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z.Cell Metab. 2022 Nov.  Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
  45. Flam E, Jang C, Murashige D, Yang Y, Morely MP, Jung S, Kantner DS, Pepper H, Bedi KC, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z. Nature Cardiovasc Res. 2022. 1: 817-829, Sep 2022.  Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy.
  46. Arany Z.  Circulation. 2022 Jul 5;146(1):4-5. It Is Time to Offer Genetic Testing to Women With Peripartum Cardiomyopathy.
  47. Vanweert F, Neinast M, Tapia EE, van de Weijer T, Hoeks J, Schrauwen- Hinderling VB, Blair MC, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E. Nat Commun. 2022 Jun 18;13(1):3508. A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes.
  48. Arany Z, Hilfiker-Kleiner D, Karumanchi SA. Circ Res. 2022 Jun 10;130(12):1763-1779. Animal Models of Cardiovascular Complications of Pregnancy.
  49. Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Circulation. 2022 May 24;145(21):1625-1628. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure.
  50. Kouzu H, Tatekoshi Y, Chang HC, Shapiro JS, McGee WA, De Jesus A, Ben-Sahra I, Arany Z, Leor J, Chen C, Blackshear PJ, Ardehali H. J Clin Invest.  March 2022.  ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice.
  51. Li K, Wada S, Gosis BS, Thorsheim C, Loose P, Arany Z.  PLoS Biology.  March 2022.  Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
  52. Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z.  Science.  2022 Apr 15;376(6590), Epub 2022 Apr 15. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. 
  53. Lee HW, Xu Y, Zhu X, Jang C, Choi W, Bae H, Wang W, He L, Jin SW, Arany Z, Simons M. EMBO J. 2022 Mar 3:e109890. doi: 10.15252/embj.2021109890. Epub ahead of print. PMID: 35243676. Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance.
  54. Ibrahim A, Neinast MD, Li K, Noji M, Kim B, Bornstein MR, Mohammed R, Wellen KE, Arany Z.  J Cell Sci. 2022 Mar 1;135(5):jcs258964. doi: 10.1242/jcs.258964. Epub 2021 Dec 16. PMID: 34779480; PMCID: PMC8729779.  Insulin-stimulated adipocytes secrete lactate to promote endothelial fatty acid uptake and transport.
  55. Kim B, Arany Z.  Cold Spring Harb Perspect Med.2022 Jan 24:a041162. doi: 10.1101/cshperspect.a041162. Epub ahead of print. PMID: 35074792. Endothelial Lipid Metabolism.
  56. Mc Afee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.  Sci Trans Med. 2021 Nov. 13 (618).  Truncated Titin Proteins in Dilated Cardiomyopathy.
  57. Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobson EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T.  Science. 2021 Jul 30. Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
  58. Tamrat R, Kang Y, Scherrer-Crosbie M, Levine LD, Arany Z, Lewey J. ESC Heart Failure.  2021 May 4.  Women with paripartum cardiomyopathy have normal ejection fraction, but abnormal systolic strain, during pregnancy.
  59. Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM, Arany Z; IMAC-2 and IPAC investigators.  Circulation. 2021 April 20.  Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.  
  60. Getz KD, Lewey J, Tam V, Irizarry OC, Levine LD, Aplenc R, Arany Z.  Am. Heart J. 2021 April 12. Neighborhood education status drives racial disparities in clinical outcomes of PPCM.  
  61. Blair MC, Neinast MD, Arany Z.  Biochem J. 2021 Feb 26; 478 (4):  765-776.  Whole-body metabolic fate of branched-chain amino acids. 
  62. Yucel N, Axsom J, Yang Y, Li L, Rhoades JH, Arany Z. Elife. 2020 Dec 14.  Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes.
  63. Edwards JJ, Brandimarto J, Hu DQ, Jeong S, Yucel N, Li L, Bedi KC Jr, Wada A, Murashige D, Hwang HTV, Zhao M, Margulies KB, Bernstein D, Reddy S, Arany Z.  Front Cardiovasc Med. 2020 Oct 7, 7:582407.  Noncanonical WNT Activation in Human Right Ventricular Heart Failure.
  64. Murashige D, Jang C, Neinast M, Edwards J, Rabinowitz JD, Frankel DS, Arany Z. Science. 2020 Oct 16, 370: 364.  Comprehensive quantification of fuel use by the human heart.
  65. Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz JD.  Nat Metab. 2020 Jul; 2(7): 586-593.  The small intestine shields the liver from fructose-induced steatosis.  
  66. Ibrahim A, Yucel N, Kim B, Arany Z.  Cell Metab. 2020 Jun 2:S1550-4131(20)30257-6.  Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport.
  67.  Yang S, Loro E, Wada S, Kim B, Tseng WJ, Li K, Khurana TS, Arany Z.   Skelet Muscle. 2020 May 6;10(1):14. Functional effects of muscle PGC-1alpha in aged animals.
  68. Yucel N, Arany Z.  Curr Opin Physiol. 2019 Dec;12:44-50. Fat, Obesity, and the Endothelium.
  69. Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U.  J Am Coll Cardiol. 2020 Jan 21;75(2):207-221. Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
  70. Arany Z. N Engl J Med. 2019 Dec 5;381(23):2270-2272. Taking a BAT to the Chains of Diabetes.
  71. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z.  Nature. 2019 Nov;575(7782):375-379.  The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
  72. Arany Z, Feldman AM.  JACC Basic Transl Sci. 2019 Jun 24;4(3):301-303.  To Breastfeed or Not to Breastfeed With Peripartum Cardiomyopathy.
  73. Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.   Circulation. 2019 Jul 2;140(1):42-54. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
  74. Kim B, Arany Z.  Circulation. 2019 May 7;139(19):2256-2259.  Does Glycine cataBOLAsm Drive Pulmonary Hypertension?
  75. Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD.   Nat Metab. 2019 Mar;1:404-415. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.
  76. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z.  JCI Insight. 2019 Mar 7;5(6):e126939. Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.
  77. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.  Cell. 2019 Feb 7;176(4):944-945.  Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Selected list of key publications.  

  1. Forelli N, Thome T, Eaton D, Patel J, Bowman CE, Kawakami R, Kuznetsov IA, Li K, Brady C, Bedi K, Yang Y, Koya K, Megill E, Kanter DS, Smith LG, Bowman GR, Snyder N, Edwards J, Margulies K, Arany Z. SGLT2 inhibitors activate pantothenate kinase in the human heart. 2026 pending.

  2. Baker DJ, Frommer LM, Uslu U, Patel KK, Zhu D, Engel NW, George JM, Zhao W, Kim SI, Sun L, Roselle C, Rommel PC, Young RM, Epstein JA, Hayat S, Arany Z, June CH. AI-driven discovery of GPNMB CAR T cells as a multi-cancer therapy. Cell. 2026 Jun 25;189(13):3871-3882

  3. Zhao W, Zhu W, Thome T, Soaita I, Jung JW, Noji MC, Li J, Bai H, Xiao Y, Yang Y, Thorsheim C, Zhou W, Yang Y, Li K, Edwards JJ, Kuznetsov IA, Kim B, Baur JA, Arany Z. NAD-dependent redox control enables endothelial quiescence and vascular stabilization during angiogenesis. Cell Metab. 2026 Jul 7;38(7):1478-1496.

  4. Axsom J, TeSlaa T, Lee WD, Chu Q, Cowan A, Bornstein MR, Neinast MD, Bartman CR, Blair MC, Li K, Thorsheim C, Rabinowitz JD, Arany Z. Quantification of nutrient fluxes during acute exercise in mice. Cell Metab. 2024 Dec 3;36(12):2560-2579.

  5. Bornstein MR, Tian R, Arany Z. Human cardiac metabolism. Cell Metab. 2024 Jul 2;36(7):1456-1481

  6. Arany Z. Peripartum Cardiomyopathy. N Engl J Med. 2024 Jan 11;390(2):154-164. 

  7. Kim B, Zhao W, Tang SY, Levin MG, Ibrahim A, Yang Y, Roberts E, Lai L, Li J, Assoian RK, FitzGerald GA, Arany Z. Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation. J Clin Invest. 2023 Dec 15;133(24)

  8. Bornstein MR, Neinast MD, Zeng X, Chu Q, Axsom J, Thorsheim C, Li K, Blair MC, Rabinowitz JD, Arany Z. Comprehensive quantification of metabolic flux during acute cold stress in mice. Cell Metab. 2023 Nov 7;35(11):2077-2092.

  9. Murashige D, Jung JW, Neinast MD, Levin MG, Chu Q, Lambert JP, Garbincius JF, Kim B, Hoshino A, Marti-Pamies I, McDaid KS, Shewale SV, Flam E, Yang S, Roberts E, Li L, Morley MP, Bedi KC Jr, Hyman MC, Frankel DS, Margulies KB, Assoian RK, Elrod JW, Jang C, Rabinowitz JD, Arany Z.Cell Metab. 2022 Nov.  Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.
  10. Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z.  Science.  2022 Apr 15;376(6590), Epub 2022 Apr 15. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. 
  11. Mc Afee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.  Sci Trans Med. 2021 Nov. 13 (618).  Truncated Titin Proteins in Dilated Cardiomyopathy.
  12. Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM, Arany Z.  Circulation.  2021 April 20.  Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.  
  13. Murashige D, Jang C, Neinast M, Edwards J, Rabinowitz JD, Frankel DS, Arany Z. Science. 2020 Oct 16, 370: 364.  Comprehensive quantification of fuel use by the human heart.
  14. Ibrahim A, Yucel N, Kim B, Arany Z.  Cell Metab. 2020 Jun 2:S1550-4131(20)30257-6.  Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport.
  15. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z.  Nature. 2019 Nov;575(7782):375-379.  The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
  16. Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.   Circulation. 2019 Jul 2;140(1):42-54. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
  17. Neinast M, Jang C, Hui S, Murashige DS, Li A, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. Cell Metabolism. 2019 Feb 5;29(2):417-429. PMID: 30449684 Whole-body metabolic fate of branched chain amino acids in health and insulin resistance.
  18. Kim B, Jang C, Dharaneeswaran H, Li J, Bhide M, Yang S, Li K, Arany Z. J Clin Invest. 2018 Oct 1. Endothelial pyruvate kinase M2 maintains vascular integrity.
  19. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z*, Guarente L*, Sinclair DA* (*co-senior). Cell. 2018 Mar 22;173(1):74-89.  Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. 
  20. Irizarry OC, Levine LD, Lewey J, Boyer T, Riis V, Elovitz MA, Arany Z.  JAMA Cardiol. 2017 Oct 11.  Comparison of Clinical Characteristics and Outcomes of Peripartum Cardiomyopathy Between African American and Non-African American Women. 
  21. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z.  Nat Med. 2016 Apr;22(4):421-6. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
  22. Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z.  N Engl J Med. 2016 Jan 21;374(3):233-41. Shared Genetic Etiology of Peripartum and Dilated Cardiomyopathies.
  23. Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Cell Met 2014 Feb 4;19(2):246-58. Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes.
  24. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker M, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, delMonte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac Angiogenic Imbalance Leads to Peri-partum Cardiomyopathy. Nature 2012 May 17;485(7398):333-8.
  25. Arany Z, Foo SY, Ma Y, Ruas J, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala S, Baek KH, Rosenzweig A, and Spiegelman BM. Nature. 2008; 451: 1008-13. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α.