Publications

Arany lab has produced over 150 publications in journals such as Nature, Cell, Science, New England Journal of Medicine, Journal of American College of Cardiology, JAMA Cardiology, Cell Metabolism and others.  

A full list of publications can be found on PubMed or on Google Scholar Profile.    

 

Highlighted Papers

Selected list of recent publications.    

  1. Arany Z.  Circulation. 2022 Jul 5;146(1):4-5. It Is Time to Offer Genetic Testing to Women With Peripartum Cardiomyopathy.
  2. Vanweert F, Neinast M, Tapia EE, van de Weijer T, Hoeks J, Schrauwen- Hinderling VB, Blair MC, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E. Nat Commun. 2022 Jun 18;13(1):3508. A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes.
  3. Arany Z, Hilfiker-Kleiner D, Karumanchi SA. Circ Res. 2022 Jun 10;130(12):1763-1779. Animal Models of Cardiovascular Complications of Pregnancy.
  4. Gibb AA, Murray EK, Huynh AT, Gaspar RB, Ploesch TL, Bedi K, Lombardi AA, Lorkiewicz PK, Roy R, Arany Z, Kelly DP, Margulies KB, Hill BG, Elrod JW. Circulation. 2022 May 24;145(21):1625-1628. Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure.
  5. Kouzu H, Tatekoshi Y, Chang HC, Shapiro JS, McGee WA, De Jesus A, Ben-Sahra I, Arany Z, Leor J, Chen C, Blackshear PJ, Ardehali H. J Clin Invest.  March 2022.  ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice.
  6. Li K, Wada S, Gosis BS, Thorsheim C, Loose P, Arany Z.  PLoS Biology.  March 2022.  Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3.
  7. Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z.  Science.  2022 Apr 15;376(6590), Epub 2022 Apr 15. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. 
  8. Lee HW, Xu Y, Zhu X, Jang C, Choi W, Bae H, Wang W, He L, Jin SW, Arany Z, Simons M. EMBO J. 2022 Mar 3:e109890. doi: 10.15252/embj.2021109890. Epub ahead of print. PMID: 35243676. Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance.
  9. Ibrahim A, Neinast MD, Li K, Noji M, Kim B, Bornstein MR, Mohammed R, Wellen KE, Arany Z.  J Cell Sci. 2022 Mar 1;135(5):jcs258964. doi: 10.1242/jcs.258964. Epub 2021 Dec 16. PMID: 34779480; PMCID: PMC8729779.  Insulin-stimulated adipocytes secrete lactate to promote endothelial fatty acid uptake and transport.
  10. Kim B, Arany Z.  Cold Spring Harb Perspect Med.2022 Jan 24:a041162. doi: 10.1101/cshperspect.a041162. Epub ahead of print. PMID: 35074792. Endothelial Lipid Metabolism.
  11. Mc Afee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.  Sci Trans Med. 2021 Nov. 13 (618).  Truncated Titin Proteins in Dilated Cardiomyopathy.
  12. Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, May RM, Robertson TF, Pai RL, Nace A, Hopkins C, Jacobson EA, Haldar M, FitzGerald GA, Behrens EM, Minn AJ, Seale P, Cotsarelis G, Kim B, Seykora JT, Li M, Arany Z, Kambayashi T.  Science. 2021 Jul 30. Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.
  13. Tamrat R, Kang Y, Scherrer-Crosbie M, Levine LD, Arany Z, Lewey J. ESC Heart Failure.  2021 May 4.  Women with paripartum cardiomyopathy have normal ejection fraction, but abnormal systolic strain, during pregnancy.
  14. Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Rana S, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM, Arany Z; IMAC-2 and IPAC investigators.  Circulation. 2021 April 20.  Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.  
  15. Getz KD, Lewey J, Tam V, Irizarry OC, Levine LD, Aplenc R, Arany Z.  Am. Heart J. 2021 April 12. Neighborhood education status drives racial disparities in clinical outcomes of PPCM.  
  16. Blair MC, Neinast MD, Arany Z.  Biochem J. 2021 Feb 26; 478 (4):  765-776.  Whole-body metabolic fate of branched-chain amino acids
  17. Yucel N, Axsom J, Yang Y, Li L, Rhoades JH, Arany Z. Elife. 2020 Dec 14.  Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes.
  18. Edwards JJ, Brandimarto J, Hu DQ, Jeong S, Yucel N, Li L, Bedi KC Jr, Wada A, Murashige D, Hwang HTV, Zhao M, Margulies KB, Bernstein D, Reddy S, Arany Z.  Front Cardiovasc Med. 2020 Oct 7, 7:582407.  Noncanonical WNT Activation in Human Right Ventricular Heart Failure.
  19. Murashige D, Jang C, Neinast M, Edwards J, Rabinowitz JD, Frankel DS, Arany Z. Science. 2020 Oct 16, 370: 364.  Comprehensive quantification of fuel use by the human heart.
  20. Jang C, Wada S, Yang S, Gosis B, Zeng X, Zhang Z, Shen Y, Lee G, Arany Z, Rabinowitz JD.  Nat Metab. 2020 Jul; 2(7): 586-593.  The small intestine shields the liver from fructose-induced steatosis.  
  21. Ibrahim A, Yucel N, Kim B, Arany Z.  Cell Metab. 2020 Jun 2:S1550-4131(20)30257-6.  Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport.
  22.  Yang S, Loro E, Wada S, Kim B, Tseng WJ, Li K, Khurana TS, Arany Z.   Skelet Muscle. 2020 May 6;10(1):14. Functional effects of muscle PGC-1alpha in aged animals.
  23. Yucel N, Arany Z.  Curr Opin Physiol. 2019 Dec;12:44-50. Fat, Obesity, and the Endothelium.
  24. Davis MB, Arany Z, McNamara DM, Goland S, Elkayam U.  J Am Coll Cardiol. 2020 Jan 21;75(2):207-221. Peripartum Cardiomyopathy: JACC State-of-the-Art Review.
  25. Arany Z. N Engl J Med. 2019 Dec 5;381(23):2270-2272. Taking a BAT to the Chains of Diabetes.
  26. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z.  Nature. 2019 Nov;575(7782):375-379.  The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
  27. Arany Z, Feldman AM.  JACC Basic Transl Sci. 2019 Jun 24;4(3):301-303.  To Breastfeed or Not to Breastfeed With Peripartum Cardiomyopathy.
  28. Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.   Circulation. 2019 Jul 2;140(1):42-54. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
  29. Kim B, Arany Z.  Circulation. 2019 May 7;139(19):2256-2259.  Does Glycine cataBOLAsm Drive Pulmonary Hypertension?
  30. Chen L, Zhang Z, Hoshino A, Zheng HD, Morley M, Arany Z, Rabinowitz JD.   Nat Metab. 2019 Mar;1:404-415. NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism.
  31. Li J, Wada S, Weaver LK, Biswas C, Behrens EM, Arany Z.  JCI Insight. 2019 Mar 7;5(6):e126939. Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.
  32. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA.  Cell. 2019 Feb 7;176(4):944-945.  Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

Selected list of key publications.  

  1. Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z.  Science.  2022 Apr 15;376(6590), Epub 2022 Apr 15. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. 
  2. Mc Afee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.  Sci Trans Med. 2021 Nov. 13 (618).  Truncated Titin Proteins in Dilated Cardiomyopathy.
  3. Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, DePalma S, Haghighi A, Seidman JG, Seidman CE, Jacoby D, Macones G, Judge DP, Margulies KB, Cappola TP, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Alexis JD, Boehmer J, Kamiya C, Gustafsson F, Damm P, Ersbøll AS, Goland S, Hilfiker-Kleiner D, McNamara DM, Arany Z.  Circulation.  2021 April 20.  Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.  
  4. Murashige D, Jang C, Neinast M, Edwards J, Rabinowitz JD, Frankel DS, Arany Z. Science. 2020 Oct 16, 370: 364.  Comprehensive quantification of fuel use by the human heart.
  5. Ibrahim A, Yucel N, Kim B, Arany Z.  Cell Metab. 2020 Jun 2:S1550-4131(20)30257-6.  Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport.
  6. Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z.  Nature. 2019 Nov;575(7782):375-379.  The ADP/ATP translocase drives mitophagy independent of nucleotide exchange.
  7. Haggerty CM, Damrauer SM, Levin MG, Birtwell D, Carey DJ, Golden AM, Hartzel DN, Hu Y, Judy R, Kelly MA, Kember RL, Lester Kirchner H, Leader JB, Liang L, McDermott-Roe C, Babu A, Morley M, Nealy Z, Person TN, Pulenthiran A, Small A, Smelser DT, Stahl RC, Sturm AC, Williams H, Baras A, Margulies KB, Cappola TP, Dewey FE, Verma A, Zhang X, Correa A, Hall ME, Wilson JG, Ritchie MD, Rader DJ, Murray MF, Fornwalt BK, Arany Z.   Circulation. 2019 Jul 2;140(1):42-54. Genomics-First Evaluation of Heart Disease Associated With Titin-Truncating Variants.
  8. Neinast M, Jang C, Hui S, Murashige DS, Li A, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z. Cell Metabolism. 2019 Feb 5;29(2):417-429. PMID: 30449684 Whole-body metabolic fate of branched chain amino acids in health and insulin resistance.
  9. Kim B, Jang C, Dharaneeswaran H, Li J, Bhide M, Yang S, Li K, Arany Z. J Clin Invest. 2018 Oct 1. Endothelial pyruvate kinase M2 maintains vascular integrity.
  10. Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z*, Guarente L*, Sinclair DA* (*co-senior). Cell. 2018 Mar 22;173(1):74-89.  Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. 
  11. Irizarry OC, Levine LD, Lewey J, Boyer T, Riis V, Elovitz MA, Arany Z.  JAMA Cardiol. 2017 Oct 11.  Comparison of Clinical Characteristics and Outcomes of Peripartum Cardiomyopathy Between African American and Non-African American Women. 
  12. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z.  Nat Med. 2016 Apr;22(4):421-6. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance.
  13. Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z.  N Engl J Med. 2016 Jan 21;374(3):233-41. Shared Genetic Etiology of Peripartum and Dilated Cardiomyopathies.
  14. Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Cell Met 2014 Feb 4;19(2):246-58. Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes.
  15. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker M, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, delMonte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac Angiogenic Imbalance Leads to Peri-partum Cardiomyopathy. Nature 2012 May 17;485(7398):333-8.
  16. Arany Z, Foo SY, Ma Y, Ruas J, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala S, Baek KH, Rosenzweig A, and Spiegelman BM. Nature. 2008; 451: 1008-13. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α.