Perelman School of Medicine at the University of Pennsylvania


Penn SRP Publications

(Names in bold are all Penn SRP current or past predoctoral and/or postdoctoral trainees)

  1. Dimitra Kokkinaki, Matthew Hoffman, Charikleia Kalliora, Ioannis D. Kyriazis, Jennifer Maning, Anna Maria Lucchese, Santhanam Shanmughapriya, Dhanendra Tomar, Joon Young Park, Hong Wang, Xiao-Feng Yang, Muniswamy Madesh, Anastasios Lymperopoulos, Walter J. Koch, Melpo Christofidou-Solomidou, Konstantinos Drosatos. Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 2019; 127: 232. PMID: 30611795; PMCID: PMC6359996
  2. Xu, R., Barg, F. K., Emmett, E. A., Wiebe, D. J., & Hwang, W. T. (2018). Association between mesothelioma and non-occupational asbestos exposure: systematic review and meta-analysis. Environmental Health, 17(1), 90. PMID: 30567579; PMCID: PMC6300000
  3. Ferdowsi B, Ortiz CP, Jerolmack DJ. Glassy dynamics of landscape evolution. Proc Natl Acad Sci U S A. 2018 May 8; 115(19):4827-4832. PMID: 29686102; PMCID: PMC5948954
  4. Weng L, Guo L, Vachani A, Mesaros CA, Blair IA. Quantification of Serum High Mobility Group Box-1 by Liquid Chromatography High Resolution Mass Spectrometry: Implications for its role in Immunity, Inflammation, and Cancer. Anal Chem. 2018 May 23. [Epub ahead of print]. PMID: 29791130; NIHMSID: 984592.
  5. Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD. Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4170-4175. PMID: 29610310; PMCID: PMC5910840
  6. Goodwin TJ, Christofidou-Solomidou M. Oxidative Stress and Space Biology: An Organ-Based Approach. Int J Mol Sci. 2018 Mar 23;19(4). pii: E959. doi: 10.3390/ijms19040959. PMID: 29570635. PMCID: PMC5979446
  7. Mishra OP, Popov AV, Pietrofesa RA, Nakamaru-Ogiso E, Andrake M, Christofidou-Solomidou M. Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells. 2018 Mar 7; 1862(6):1364-1375. PMID: 29524540; PMCID: PMC5970065
  8. Pietrofesa RA, Chatterjee S, Park K, Arguiri E, Albelda SM, Christofidou-Solomidou M. Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner. Antioxidants (Basel). 2018 Mar 2; 7(3). PMCID: PMC5874524 
  9. Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C. Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res. 2018 Mar; 59(3):564-575. PMID: 29301865; PMCID: PMC5832923
  10. Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Rocha AG, Dancis A, Mesaros C, Lynch DR, Blair IA. Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia. Anal Chem. 2018 Feb 6; 90(3):2216-2223. PMCID: PMC5817373
  11. Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M. Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage. Int J Mol Sci. 2017 Nov 25; 18(12). pii: E2525. PMID: 29186841; PMCID: PMC5751128
  12. Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper B, Christofidou-Solomidou M, Willenbring JK. Siderophore-mediated iron removal from chrysotile: Implications for asbestos toxicity reduction and bioremediation. J Hazard Mater 2018 Jan 5, 341 290-296. PMID:28797944; PMCID: PMC5771417
  13. Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM. Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice. Cancer Prev Res (Phila). 2018 Jan; 11(1):27-37.  PMID: 29074535; PMCID: PMC5754250
  14. Huang J, Liu Y, Vitale S, Penning TM, Whitehead AS, Blair IA, Vachani A, Clapper ML, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y. On meta- and mega-analyses for gene-environment interactions. Genet Epidemiol. 2017 Dec;41(8):876-886. PMID: 29110346; PMCID: PMC5775907
  15. Gonneau C, Miller K, Mohanty SK, Xu R, Hwang WT, Willenbring JK, Casper BB. Framework for assessment and phytoremediation of asbestos-contaminated sites. Environ Sci Pollut Res Int. 2017 Nov; 24(33):25912-25922. doi: 10.1007/s11356-017-0177-x. Epub 2017 Sep 22. PMID:28940054; PMCID: PMC5769457
  16. Cubuk ED, Ivancic RJS, Schoenholz SS, Strickland DJ, Basu A, Davidson ZS, Fontaine J, Hor JL, Huang YR, Jiang Y, Keim NC, Koshigan KD, Lefever JA, Liu T, Ma XG, Magagnosc DJ, Morrow E, Ortiz CP, Rieser JM, Shavit A, Still T, Xu Y, Zhang Y, Nordstrom KN, Arratia PE, Carpick RW, Durian DJ, Fakhraai Z, Jerolmack DJ, Lee D, Li J, Riggleman R, Turner KT, Yodh AG, Gianola DS, Liu AJ. Structure-property relationships from universal signatures of plasticity in disordered solids. Science. 2017 Nov 24; 358(6366):1033-1037. PMID: 29170231; PMC6047528
  17. Ferdowsi B, Ortiz CP, Houssais M, Jerolmack DJ. River-bed armouring as a granular segregation phenomenon. Nat Commun. 2017; Nov 8;8(1):1363. doi: 10.1038/s41467-017-01681-3. PMCID: PMC5678076
  18. Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teitelbaum SL, Amos CI. Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiol Biomarkers Prev. 2017 Sep; 26 (9):1370-1380. PMCID: PMC5581729 
  19. Pietrofesa RA, Woodruff P, Hwang WT, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M. The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages. Oxid Med Cell Longev. 2017 Sep; PMID: 29075366; PMCID: PMC5615985
  20. Dietterich LH, Gonneau C, Casper BB. Arbuscular mycorrhizal colonization has little consequence for plant heavy metal uptake in contaminated field soils. Ecol Appl. 2017 Sep; 27(6):1862-1875. PMCID: PMC5581990
  21. Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT. Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomark Med. 2017 Jul; 11(7):547-556. PMID:28534416; PMCID: PMC5619144
  22. Gonneau C, Mohanty SK, Dietterich LH, Hwang W, Willenbring JK, Casper BB. 2017. Differential elemental uptake in three pseudo-metallophyte C4 grasses in situ in the eastern USA. Plant Soil 1 2017 Jul; 416(1-2):149-163. PMID:28845059, PMCID: PMC5568086
  23. Cheung M, Testa JR.  BAP1, a tumor suppressor gene driving malignant mesothelioma. Transl Lung Cancer Res. 2017 Jun; 6(3):270-278. PMID: 28713672; PMCID: PMC5504107.
  24. Mesaros C, Arroyo AD, Blair IA, Snyder NW. Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat. 2017 May;130:1-7. PMID 28238887; PMCID: PMC5446925.
  25. Wu L, Ortiz CP, and Jerolmack DJ. Aggregation of  elongated colloids in water. Langmuir.  2017 Jan 17;33(2):622-629. PMID: 27931099 PMCID: PMC5283798.
  26. Mesaros C, Weng L and Blair IA. (2017) “Chapter 12: Biomarkers of response to asbestos exposure.” In Current Cancer Research:  Asbestos and Mesothelioma, Ed, Testa, Joseph R., Springer International Publishing AG. Pp 259 – 277.  Chapter 12
  27. Cheung M, Menges CW, and Testa JR. (2017) “Chapter 8: Germline and Somatic Mutations in Human Mesothelioma and Lessons from Asbestos-Exposed Genetically Engineered Mouse Models."  In Current Cancer Research:  Asbestos and Mesothelioma, Ed, Testa, Joseph R., Springer International Publishing AG. Pp 175 — 195. Chapter 8
  28. Emmett EA, and Cakouros B. (2017) “Chapter 5: Communities at High Risk in the Third Wave of Mesothelioma."  In Current Cancer Research:  Asbestos and Mesothelioma, Ed, Testa, Joseph R., Springer International Publishing AG. Pp 103 - 130.  Chapter 5
  29. Testa JR.  (2017) “Chapter 1: Malignant Mesothelioma: An Asbestos Legacy." In Current Cancer Research:  Asbestos and Mesothelioma, Ed, Testa, Joseph R., Springer International Publishing AG. Pp 1 - 9.  Chapter 1
  30. Testa JR (ed.).  Asbestos and Mesothelioma.  Current Cancer Research.  Series ed.:  El-Deiry, W.  Heidelberg: Springer Verlag, 2017.
  31. Houssais M, Ortiz CP, Durian DJ, Jerolmack DJ. Rheology of sediment transported by a laminar flow. Phys Rev E. 2016 Dec; 94(6-1):062609. PMID: 28085450 – Review. PMCID: PMC6035050 
  32. Clapp JT, Roberts JA, Dahlberg B, Berry LS, Jacobs LM, Emmett EA, Barg FK. Realities of environmental Toxicity and their ramifications for community engagement. Soc Sci Med 2016 Dec; 170: 143-151. PMID: 27783970; PMCID: PMC5107345 
  33. Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW. Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry.  Steroids. 2016 Dec;116:60-66. PMID: 27743906; PMCID: PMC5127713
  34. Mesaros C, Blair IA. Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteomics. 2016 Oct 5;13:20. Review. PMID:27713681; PMCID: PMC5050566.
  35. Mishra OP, Popov AV, Pietrofesa RA, Christofidou-Solomidou M. Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection. Biochimica et biophysica acta. Sep 2016;1860 (9):1884-1897. PMID: 27261092; PMCID: PMC5253237
  36.  Guo L, Worth AJ, Mesaros AC, Snyder NW, Glickson JD, and Blair IA. Diisopropylethylamine/ hexafluoroisopropanol-mediated ion-pairing UHPLC-MS for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism Rapid Commun. Mass Spectrom. 2016 Aug 30;30(16):1835-45; PMID: 27476658; PMCID: PMC4970762 
  37. Salamatipour A, Mohanty SK, Pietrofesa RA, Vann DR, Christofidou-Solomidou M, and Willenbring JK. Asbestos Fiber Preparation Methods Affect Fiber Toxicity. Environ Sci Technol Lett, 2016 Jul 12, 3(7), pp270-274  PMID: 27540559; PMCID: PMC4985249 
  38. Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M. Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel. Int J Mol Sci. 2016 Jun 16: 17(6). PMID: 27322243; PMCID: PMC4926486
  39. Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res. 2016 May 1;76(9):2836-44. PMID: 26896281; PMCID: PMC4873414
  40. Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR. Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma. Cancer Prev Res (Phila). 2016 May;9(5):406-14. PMID: 26935421; PMCID: PMC4854753. *Most highly cited Cancer Prevention Research articles published in 2016.
  41. Kadariya Y, Cheung M, Xu J, Pei J, Sementino E, Menges CW, Cai KQ, Rauscher FJ, Klein-Szanto AJ, Testa JR. Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations. Cancer Res. 2016 May 1;76(9):2836-44. PMID: 26896281; PMCID: PMC4873414
  42. Sharkhuu A, Plante A, Enkhmandal O, Gonneau C, Casper B, Boldgiv B, and Petraitis P.  Soil and ecosystem respiration responses to grazing, watering and experimental warming chamber treatments across topographical gradients in northern Mongolia. Geoderma 2016, 269, 91-98. PMID: 28239190; PMCID: PMC5325163
  43. Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M. Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605). Int J Mol Sci. 2016 Mar 1;17(3). PMID: 26938529 PMCID: PMC4813184
  44. Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang WT, Albelda SM, Christofidou-Solomidou M. Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice. Carcinogenesis. 2016 Feb;37(2):177-87. PMID: 26678224; PMCID: PMC4745643.
  45. Ohar JA, Cheung M, Talarchek J, Howard SE, Howard TD, Hesdorffer M, Peng H, Rauscher FJ, Testa JR. Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer. Cancer Res. 2016 Jan 15;76(2):206-15. PMID: 26719535; PMCID: PMC4715907
  46. Cheung M, Kadariya Y, Talarchek J, Pei J, Ohar JA, Kayaleh OR, Testa JR. Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction. Cancer Lett. 2015 Dec 28;369(2):261-5. PMID: 26409435; PMCID: PMC4634709.
  47. Velalopoulou A, Tyagi S, Pietrofesa RA, Arguiri E, Christofidou-Solomidou M. The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage. Int J Mol Sci. 2015 Dec 22;17(1) PMID: 26703588; PMCID: PMC4730254.
  48. Wu L, Ortiz C, Xu Y, Willenbring J, Jerolmack D. In Situ Liquid Cell Observations of Asbestos Fiber Diffusion in Water. Environ Sci Technol. 2015 Nov 17;49(22):13340-9. PMID: 26461183; PMCID: PMC4747642.
  49. Cheung M, Kadariya Y, Pei J, Talarchek J, Facciolo F, Visca P, Righi L, Cozzi I, Testa JR, Ascoli V. An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation. Cancer Genet. 2015 Oct;208(10):502-7. PMID: 26364129; PMCID: PMC4608746.
  50. Snyder NW, Golin-Bisello F, Gao Y, Blair IA, Freeman BA, Wendell SG. 15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways. Chem Biol Interact. 2015 Jun 5;234:144-53.  PMID: 25450232; PMCID: PMC4414684.
  51. Snyder NW, Tombline G, Worth AJ, Parry RC, Silvers JA, Gillespie KP, Basu SS, Millen J, Goldfarb DS, Blair IA. Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture. Anal Biochem. 2015 Apr 1;474:59-65. PMID: 25572876; PMCID: PMC4413507.
  52. Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Bioanalysis. 2015;7(9):1157-73. PMID: 26039812; PMCID: PMC4487641.
  53. Snyder NW, Mesaros C, Blair IA. Translational metabolomics in cancer research. Biomark Med. 2015;9(9):821-34. PMID: 26329905;  PMCID: PMC4718447 .