Welcome To The Blair Lab
We are one the member labs within the Center of Excellence in Environmental Toxicology (CEET) in the Systems Pharmacology & Translational Therapeutics Department.
Dr. Blair's laboratory is located on the eighth floor of the Biomedical Research Building II/III on Curie Boulevard in the Perelman School of Medicine at the University of Pennsylvania. The laboratory is equipped with four triple quadrupole mass spectrometers (Thermo TSQ Vantage, Thermo TSQ Ultra, Agilent 6460, Agilent 6490) and two high-resolution ion trap mass spectrometers (Thermo Q-Exactive HF Hybrid Quadrupole-Orbitrap mass spectrometers). There is also a full-equipped laboratory for wet-lab experiments, organic synthesis, and cell culture. The availability of this instrumentation allows both quantitative and structural determinations to be performed in our many collaborative projects.
The 57th ASMS Conference was held in Philadelphia, Pennsylvania May 31st through June 4th, 2009. The Blair Group participated "en masse" - we had a total of 16 posters and one oral presentation. The 69th ASMS Conference will again be held in Philadelphia in 2021 from October 31st to November 4th. This time we have 5 posters and are looking forward to meeting up with the folks who attended the 2009 conference - 12-years ago!
Lab Image Gallery
Zhang Y, Xu Y, Lu W, Ghergurovich JM, Guo L, Blair IA, Rabinowitz JD, Yang X. Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab. 2021;33(1):94-109 e8. Epub 2020/11/08. doi: 10.1016/j.cmet.2020.10.002. PubMed PMID: 33159852; PMCID: PMC7846267
Weng L, Laboureur L, Wang Q, Guo L, Xu P, Gottlieb L, Lynch DR, Mesaros C, Blair IA. Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich's ataxia. Sci Rep. 2020;10(1):15788. Epub 2020/09/27. doi: 10.1038/s41598-020-72884-w. PubMed PMID: 32978498; PMCID: PMC7519113.
Weng L, Wang Q, Yu S, Yang X, Lynch DR, Mesaros C, Blair IA. Evaluation of antibodies for western blot analysis of frataxin protein isoforms. J Immunol Methods. 2019 474:112629. doi: 10.1016/j.jim.2019.07.001. PubMed PMID: 31279523 PMCID: PMC6829029