Recent Publications

2021

Zhang Y, Xu Y, Lu W, Ghergurovich JM, Guo L, Blair IA, Rabinowitz JD, Yang X. Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation. Cell Metab. 2021;33(1):94-109 e8. Epub 2020/11/08. doi: 10.1016/j.cmet.2020.10.002. PubMed PMID: 33159852; PMCID: PMC7846267

2020

Weng L, Laboureur L, Wang Q, Guo L, Xu P, Gottlieb L, Lynch DR, Mesaros C, Blair IA. Extra-mitochondrial mouse frataxin and its implications for mouse models of Friedreich's ataxia. Sci Rep. 2020;10(1):15788. Epub 2020/09/27. doi: 10.1038/s41598-020-72884-w. PubMed PMID: 32978498; PMCID: PMC7519113.

2019

Weng L, Wang Q, Yu S, Yang X, Lynch DR, Mesaros C, Blair IA. Evaluation of antibodies for western blot analysis of frataxin protein isoforms. J Immunol Methods. 2019 474:112629. doi: 10.1016/j.jim.2019.07.001. PubMed PMID: 31279523 PMCID: PMC6829029

2018

Weng L, Guo L, Vachani A, Mesaros CA, Blair IA. Quantification of Serum High Mobility Group Box-1 by Liquid Chromatography High Resolution Mass Spectrometry: Implications for its role in Immunity, Inflammation, and Cancer. Anal Chem. 2018 Jun 19;90(12):7552-7560. PMID: 29791130

Ochocki JD, Khare S, Hess M, Ackerman D, Qiu B, Daisak JI, Worth AJ, Lin N, Lee P, Xie H, Li B, Wubbenhorst B, Maguire TG, Nathanson KL, Alwine JC, Blair IA, Nissim I, Keith B, Simon MC. Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity. Cell Metab. 2018 Jun 5;27(6):1263-1280. PMID: 29754953; PMCID: PMC5990482

O'Connor RS, Guo L, Ghassemi S, Snyder NW, Worth AJ, Weng L, Kam Y, Philipson B, Trefely S, Nunez-Cruz S, Blair IA, June CH, Milone MC. The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations. Sci Rep. 2018 Apr 19; 8(1):6289. PMID: 29674640; PMCID: PMC5908836

Ecker C, Guo L, Voicu S, Gil-de-Gómez L, Medvec A, Cortina L, Pajda J, Andolina M, Torres-Castillo M, Donato JL, Mansour S, Zynda ER, Lin PY, Varela-Rohena A, Blair IA, Riley JL. Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments. Cell Rep. 2018 Apr 17; 23(3):741-755. PMID: 29669281; PMCID: PMC5929999

Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4170-4175. PMID: 29610310; PMCID: PMC5910840

Yue W, Wang J, Atkins KA, Bottalico L, Mesaros C, Blair IA, Santen RJ. Effect of a tissue selective estrogen complex (TSEC) on breast cancer: Role of unique properties of conjugated equine estrogen. Int J Cancer. 2018 Mar 25. doi: 10.1002/ijc.31401. [Epub ahead of print] PMID: 29577272

Shrimp JH, Garlick JM, Tezil T, Sorum AW, Worth AJ, Blair IA, Verdin E, Snyder NW, Meier JL. Defining Metabolic and Nonmetabolic Regulation of Histone Acetylation by NSAID Chemotypes. Mol Pharm. 2018 Mar 5; 15 (3):729-736. PMID: 29240439

Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C. Analysis of hydroxyeicosatetraenoic acids (HETEs) in human whole blood by chiral ultrahigh performance liquid chromatgraphy (UHPLC)-electron capture atmospheric pressure chemical ionization/high resolution mass spectrometry (UHPLC-ECAPCI/HRMS). J Lipid Res. 2018 Mar;59 (3):564-575. PMID: 29301865; PMCID: PMC5832923

Wang Q, Guo L, Strawser CJ, Hauser LA, Hwang WT, Snyder NW, Lynch DR, Mesaros C, Blair IA. Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy. PLoS One. 2018 Feb 15; 13 (2):e0192779. PMCID PMC5813973

Guo L, Wang Q, Weng L, Hauser LA, Strawser CJ, Rocha AG, Dancis A, Mesaros C, Lynch DR, Blair IA. Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia. Anal Chem. 2018 Feb 6; 90 (3):2216-2223. PMID: 29272104. PMCID: PMC5817373

2017

Sinclair WR, Shrimp JH, Zengeya TT, Kulkarni RA, Garlick JM, Luecke H, Worth AJ, Blair IA, Snyder NW, Meier JL. Bioorthogonal pro-metabolites for profiling short chain fatty acylation. Chem Sci. 2017 Dec 8; 9(5):1236-1241. PMID: 29675169; PMCID: PMC5885804

Mitchell CM, Srinivasan S, Plantinga A, Wu MC, Reed SD, Guthrie KA, LaCroix AZ, Fiedler T, Munch M, Liu C, Hoffman NG, Blair IA, Newton K, Freeman EW, Joffe H, Cohen L, Fredricks DN. Associations between improvement in genitourinary symptoms of menopause and changes in the vaginal ecosystem. Menopause. 2017 Dec 4. PMID: 29206774; PMCID: PMC5607086.

Huang J, Liu Y, Vitale S, Penning TM, Whitehead AS, Blair IA, Vachani A, Clapper ML, Muscat JE, Lazarus P, Scheet P, Moore JH, Chen Y. On meta- and mega-analyses for gene-environment interactions. Genet Epidemiol. 2017 Dec; 41 (8):876-886. PMID: 29110346; PMCID: PMC5775907

Huang M, Mesaros C, Hackfeld LC, Hodge RP, Blair IA, Penning TM. Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1- Methylphenanthrene and 9-Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chem Res Toxicol. 2017 Dec 18; 30 (12):2140-2150. PMID: 29035516; PMCID: PMC5734992

Else T, Marcondes Lerario A, Everett J, Haymon L, Wham D, Mullane M, Wilson TL, Rainville I, Rana H, Worth AJ, Snyder NW, Blair IA, McKay R, Kilbridge K, Hammer GD, Barletta J, Vaiyda A. Adrenocortical carcinoma and succinate dehydrogenase gene mutations. Eur J Endocrinol. 2017 Aug 17177, 439–444. PMID: 28819017; PMCID: PMC

Sims C, Salliant N, Worth AJ, Parry R, Mesaros C, Blair IA, Snyder NW. Metabolic tracing analysis reveals substrate-specific metabolic deficits in platelet storage lesion. Transfusion. 2017 Nov;57(11):2683-2689 PMID:28836286; PMCID: PMC5787404

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA. Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Cell Chem Biol. 2017 Oct 19; 24(10):1259-1275.e6. PMID:28919040; PMCID: PMC5650512. Published Erratum, Cell Chem Biol. 2017 Oct 19; 24(10):1314.

McAllister K, Mechanic LE, Amos C, Aschard H, Blair IA, Chatterjee N, Conti D,Gauderman WJ, Hsu L, Hutter CM, Jankowska MM, Kerr J, Kraft P, Montgomery SB, Mukherjee B, Papanicolaou GJ, Patel CJ, Ritchie MD, Ritz BR, Thomas DC, Wei P, Witte, JS. Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases. Am J Epidemiol. 2017 Oct 1; 186(7):753-761. PMID: 28978193;

Mitchell CM, Srinivasan S, Zhan X, Wu MC, Reed SD, Guthrie KA, LaCroix AZ, Fiedler T, Munch M, Liu C, Hoffman NG, Blair IA, Newton K, Freeman EW, Joffe H, Cohen L, Fredricks DN. Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis. Menopause. 2017 Oct; 24(10):1160-1166. PMID:28640154; PMCID: PMC5607086

Schick SF, Blount BC, Jacob P 3rd, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A. Biomarkers of Exposure to New and Emerging Tobacco and Nicotine Delivery Products. Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1; 313 (3):L425-L452. PMID: 28522563; PMCID: PMC5626373

Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska MM, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teiltelbaum SL, Amos CI. Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies. Cancer Epidemiol Biomarkers Prev. 2017 Sep; 26(9):1370-1380. PMID: 28710076; PMCID: PMC5581729

Zang T, Taplin ME, Tamae D, Xie W, Mesaros C, Zhang Z, Bubley GJ, Montgomery RB, Balk S, Mostaghel E, Blair IA, Penning T. Testicular versus adrenal sources of hydroxyandrogens in prostate cancer Endocr Relat Cancer. 2017 Aug; 24(8):393-404.  PMID: 28663228; PMCID: PMC5593253

Xu R, Mesaros C, Weng L, Snyder NW, Vachani A, Blair IA, Hwang WT. Comparison of statistical methods for detection of serum lipid biomarkers for mesothelioma and asbestos exposure. Biomark Med. 2017 Jul; 11(7):547-556. PMID:28534416; PMCID: PMC PMC5619144

Angelin A, Gil-de-Gómez L, Dahiya S, Jiao J, Guo L, Levine MH, Wang Z, Quinn WJ 3rd, Kopinski PK, Wang L, Akimova T, Liu Y, Bhatti TR, Han R, Laskin BL, Baur JA, Blair IA, Wallace DC, Hancock WW, Beier UH. Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. Cell Metab. 2017 Jun 6; 25(6):1282-1293.e7. PMID: 28416194, PMCID: PMC5462872

Mesaros C, Arroyo AD, Blair IA, Snyder NW. Coenzyme A thioester formation of 11- and 15-oxo-eicosatetraenoic acid. Prostaglandins Other Lipid Mediat. 2017 Feb 24; 130:1-7. PMID: 28238887; PMCID: PMC5446925

Huang M, Mesaros C, Hackfeld LC, Hodge RP, Zang T, Blair IA, Penning TM. Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chem Res Toxicol. 2017 Apr 17; 30 (4): 1093-1101. PMID: 28278373; PMCID: PMC5593134

Bagley SJ, Vitale S, Zhang S, Aggarwal C, Evans TL, Alley EW, Cohen RB, Langer CJ, Blair IA, Vachani A, Whitehead AS. Pretreatment Red Blood Cell Total Folate Concentration Is Associated With Response to Pemetrexed in Stage IV Nonsquamous Non-Small-cell Lung Cancer. Clin Lung Cancer. 2017 Mar; 18(2):e143-e149. PMID: 27863923; PMCID: PMC5346447

Carrer A, Parris JLD, Trefely S, Henry RA, Montgomery DC, Torres AM, Viola JM, Kuo Y-M, Blair IA, MeierJL, Andrews AJ, Snyder NW, and Wellen KE. Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. J Biol Chem 2017 Feb 24; 292 (8) :3312-3322. PMID: 28077572. PMCID: PMC 53366165

Kulkarni RA, Worth AJ, Zengeya TT, Shrimp JH, Garlick JM, Roberts AM, Montgomery DC, Sourbier C, Gibbs BK, Mesaros C, Tsai YC, Das S, Chan KC, Zhou M, Andresson T, Weissman AM, Linehan WM, Blair IA, Snyder NW, Meier JL. Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chem Biol. 2017 Feb 16; 24 (2):231-242. PMID: 28163016

Zang T, Tamae D, Mesaros C, Wang Q, Huang M, Blair IA, Penning TM. Simultaneous Quantitation of Nine Hydroxy-Androgens and Their Conjugates in Human Serum by Stable Isotope Dilution Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry. J Steroid Biochem Mol Biol. 2017 Jan; 165(Pt B):342-355. PMID: 27531846; PMCID: PMC5146996.

Pinney SE, Mesaros CA, Snyder NW, Busch CM, Xiao R, Aijaz S, Ijaz N, Blair IA, Manson JM. Second trimester amniotic fluid bisphenol a concentration is associated with decreased birth weight in term infants. Reprod Toxicol. 2017 Jan; 67:1-9. PMID: 27829162; PMCID: PMC5303174

2016
Nath K, Guo L, Nancolas B, Nelson DS, Shestov AA, Lee SC, Roman J, Zhou R, Leeper DB, Halestrap AP, Blair IA, Glickson JD. Mechanism of antineoplastic activity of lonidamine. Biochim Biophys Acta. 2016 Aug 4; 1866 (2):151-162. PMID: 27497601; PMCID: PMC5138080

Frey AJ, Wang Q, Busch C, Feldman D, Bottalico L, Mesaros CA, Blair IA, Vachani A, Snyder NW. Validation of highly sensitive simultaneous targeted and untargeted analysis of keto-steroids by Girard P derivatization and stable isotope dilution-liquid chromatography-high resolution mass spectrometry. Steroids. 2016 Oct 13; 116:60-66. PMID: 27743906; PMCID: PMC5127713

Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE. ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep. 2016 Oct 18; 17 (4):1037-1052. PMID: 27760311. PMCID: PMC5175409

Mesaros C, Blair IA. Mass spectrometry-based approaches to targeted quantitative proteomics in cardiovascular disease. Clin Proteom 2016 Oct 5;13:20. eCollection. PMID: 27713681; PMCID: PMCID: PMC5050566

Wang Q, Mesaros C, Blair IA. Ultra-high sensitivity analysis of estrogens for special populations in serum and plasma by liquid chromatography-mass spectrometry: Assay considerations and suggested practices. J Steroid Biochem Mol Biol. 2016 Sep; 162:70-9. PMID: 26767303; PMCID: PMC4931956

Guo L, Worth AJ, Mesaros AC, Snyder NW, Glickson JD, and Blair IA. Diisopropylethylamine/hexafluoroisopropanol-mediated ion-pairing UHPLC-MS for phosphate and carboxylate metabolite analysis: utility for studying cellular metabolism Rapid Commun. Mass Spectrom. 2016 Aug 30; 30(16):1835-45; PMID: 27476658; PMCID: PMC4970762

Mazaleuskaya LL, Lawson JA, Li X, Grant G, Mesaros C, Grosser T, Blair IA, Ricciotti E, FitzGerald GA. A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood. J CIin Inv. 2016 Aug 4; 1 (12). pii: e87031. PMID: 27547824; PMCID: PMC4990354

Vázquez-Medina JP, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB. The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. FASEB J. 2016 Aug; 30(8):2885-98; PMID: 27178323; PMCID: PMC4970605

Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Ranganathan P, Devine SM, Burrill JS, Guo L, Sacristan C, Snyder NW, Blair IA, Milone MC, Dustin ML, Riley JL, Bernlohr DA, Murphy WJ, Fife BT, Munn DH, Miller JS, Serody JS, Freeman GJ, Sharpe AH, Turka LA, Blazar BR. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest 2016 Jul 1; 126 (7):2642-60. PMID: 27294527; PMCID: PMC4922691

Huang M, Mesaros CA, Zhang S, Blair IA, Penning TM. Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon (PAH) 6-Ethylchrysene Associated With the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells. Chem Res Toxicol. 2016 Jun 20;29(6):991-1002; PMID: 27054409; PMCID: PMC4916485

Shestov AA, Lee S-C, Nath K, Guo L, Nelson DS, Roman JC, Leeper DB, Wasik MA, Blair IA and Glickson JD. 13C MRS and LC–MS Flux Analysis of Tumor Intermediary Metabolism. Front Oncol. 2016 Jun 15; 6:135. PMID: 27379200; PMCID: PMC4908130

Daurio NA, Tuttle SW, Worth AJ, Song EY, Davis JM, et al. AMPK activation and metabolic reprogramming by tamoxifen through estrogen receptor-independent mechanisms suggests new uses for this therapeutic modality in cancer treatment. Cancer Res. 2016 Jun 1;76(11):3295-306; PMID: 27020861; PMCID: PMC4895922

Worth AJ, Marchione DM, Parry RC, Wang Q, Gillespie KP, Saillant NN, Sims C, Mesaros C, Snyder NW, Blair IA.  LC-MS Analysis of Human Platelets as a Platform for Studying Mitochondrial Metabolism. J Vis Exp. 2016 Apr 4;(110):e53941. PMID: 27077278; PMCID: PMC4841355

Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP. The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 2016 Apr 1;473(7):929-36. PMID: 26831515; PMCID: PMC4814305

Shestov AA, Mancuso A, Lee SC, Guo L, Nelson DS, Roman JC, Henry PG, Leeper DB, Blair IA, Glickson JD. Bonded Cumomer Analysis of Human Melanoma Metabolism Monitored by 13C NMR Spectroscopy of Perfused Tumor Cells. J Biol Chem. 2016 Mar 4; 291(10):5157-71. PMID: 26703469; PMCID: PMC4777850

Bedi KC Jr, Snyder NW, Brandimarto J, Aziz M, Mesaros C, Worth A, Wang L, Javaheri A, Blair IA, Margulies K, Rame JE. Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure. Circulation. 2016 Feb 23; 133(8):706-16. PMID: 26703469; PMCID: PMC4779339.

Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 2016 Feb 19;5. PubMed PMID: 26894960; PubMed Central PMCID: PMC4769166.

Kawalekar OU, O'Connor RS, Fraietta JA, Guo L, McGettigan SE, Posey AD Jr, Patel PR, Guedan S, Scholler J, Keith B, Snyder N, Blair I, Milone MC, June CH. Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells. Immunity. 2016 Feb 16; 44(2):380-90. PubMed PMID: 26885860; Free Article

Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA. Inhibition of mitochondrial complex II by the anti-cancer agent lonidamine. J Biol Chem. 2016 Jan 1;291(1):42-57. PMID: 26521302; PMCID: PMC4697178.

2015

Blair IA. A dynamic career in MS: applications to biomedical research. Future Sci OA. 2015 Nov 1; 1(4):FSO52.

Hergott CB, Roche AM, Naidu NA, Mesaros C, Blair IA, Weiser JN. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection J Clin Invest. 2015 Oct 1; 125(10):3878-90. PMID: 26426079. PMCID: PMC4607119.

Huang M, Zhang L, Mesaros C, Hackfeld LC, Hodge RP, Blair IA, Penning TM. Metabolism of an Alkylated Polycyclic Aromatic Hydrocarbon 5-Methylchrysene in Human Hepatom (HepG2) Cells. Chem Res Toxicol. 2015 Oct 5. 28(10):2045-58. PMID: 26395544, PMCID: PMC4709222.

Wang Q, Zhang S, Guo L, Busch CM, Jian W, Weng N, Snyder NW, Rangiah K, Mesaros C, Blair IA. Serum apolipoprotein A-1 quantification by LC-MS with a SILAC internal standard reveals reduced levels in smokers. Bioanalysis 2015 7(22):2895-911. PMID: 26394123. PMCID: PMC4737526

Snyder NW, Mesaros C, Blair IA. Translational metabolomics in cancer research. Biomark Med. 2015; 9(9):821-34. PMID: 26329905, PMCID: PMC4718447

Mesaros C, Blair IA. (2015) Oncology bioanalysis: from biomarkers to drug discovery. Biomark Med. 2015 Sep ;9(9):821-34. Foreword. PMID: 26329020. NIH Public Access Compliance: Not applicable [this is a review/foreword, no PMCID necessary]

Worth AJ, Basu SS, Deutsch EC, Hwang WT, Snyder NW, Lynch DR,Blair IA. Stable isotopes and LC-MS for monitoring metabolic disturbances in Friedreich's ataxia platelets. Bioanalysis 2015 7(15):1843-55. PMID: 26295986; PMCID: PMC4620983

Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, and Blair IA. Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure. Review. Bioanalysis 2015; 7(9), 1157–117. PMID: 26039812; PMCID: PMC4487641.

Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie J-P, Reinero CR, Rokach J, Powell WS. (2015) Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes, Biochem Pharmacol 2015 Aug 1 96(3):247-55. PMID: 26032638; PMCID: PMC4830392.

Wang W, Snyder N, Worth AJ, Blair IA, Witze ES. Regulation of lipid synthesis by the RNA helicase Mov10 controls Wnt5a production. Oncogenesis. 2015 Jun 1 4:e154. PMID: 26029828; PMCID: PMC4753523

Aird KM, Worth AJ, Snyder NW, Lee JV, Sivanand S, Liu Q, Blair IA, Wellen KE, Zhang R. ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence. Cell Rep. 2015 May 12; 11(6):893-901. PMID: 25937285; PCMID: PMC4431925.

Mauras N, Santen RJ, Colón-Otero G, Hossain J, Wang Q, Mesaros C, Blair IA. Estrogens and their genotoxic metabolites are increased in obese prepubertal girls. J Clin Endocrinol Metab. 2015 Jun; 100(6):2322-8. PMID: 25856214; PMCID: PMC4454805

Worth AJ, Gillespie KP, Mesaros C, Guo L, Basu SS, Snyder NW, Blair IA. Rotenone stereospecifically increases (S)-2-hydroxyglutarate in SH-SY5Y neuronal cells. Chem Res Toxicol. 2015 May 18; 28(5):948-54. PMID: 25800467; PMCID: PMC4721232.

Wang Q, Rangiah K, Mesaros C, Snyder NW, Vachani A, Song H, Blair IA. Ultrasensitive quantification of serum estrogens in postmenopausal women and older men by liquid chromatography–tandem mass spectrometry. Steroids. 2015 Apr; 96:140-52. PMID: 25637677; PMCID: PMC4369926

Snyder NW, Tombline G, Worth AJ, Parry RC, Silvers JA, Gillespie KP, Basu SS, Millen J, Goldfarb DS, Blair IA. Production of stable isotope labeled acyl-coenzyme A thioesters by yeast SILEC. Anal Biochem. 2015 Apr 1;474:59-65. PMID: 25572876; PMCID: PMC4413507

Snyder NW, Golin-Bisello F, Gao Y, Blair IA, Freeman BA, Wendell SG. 15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways. Chem Biol Interact. 2015 Jun 5;234:144-53. PMID: 25450232; PMCID: PMC4414684.

Snyder NW, Basu SS, Worth AJ, Mesaros C, Blair IA. Metabolism of propionic acid to a novel acyl-coenzyme A thioester by mammalian cell lines and platelets. J Lipid Res. 2015 Jan; 56(1):142-50. PMID: 25424005; PMCID: PMC4274062

Wang Q, Bottalico L, Mesaros C, Blair IA. Analysis of estrogens and androgens in postmenopausal serum and plasma by liquid chromatography-mass spectrometry. Steroids. 2015 Jul; 99(Pt A):76-83. PMID: 25150018; PMCID: PMC4336238

2014

Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research. Maternal serum serpin B7 is associated with early spontaneous preterm birth. Am J Obstet Gynecol. 2014 Dec; 211(6):678.e1-12. PMID:24954659; PMCID: PMC4254341.

Mesaros C, Wang Q, Blair IA. What are the main considerations for bioanalysis of estrogens and androgens in plasma and serum samples from postmenopausal women? Bioanalysis. 2014; 6(23):3073-5. PMID: 25529875; PMCID: PMC4278565.

Li X, Fries S, Li R, Lawson JA, Propert KJ, Diamond SL, Blair IA, FitzGerald GA, Grosser T. Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16830-5. PMID: 25385584; PMCID: PMC4250103.

Worth AJ, Basu SS, Snyder NW, Mesaros C, Blair IA Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation supporting acetyl-coenzyme A levels. J Biol Chem 2014 Sep 26; 289(39):26895-903. PMCID: PMC4175330

Snyder NW, Basu SS, Zhou Z, Worth AJ, and Blair IA. Stable isotope dilution liquid chromatography-mass spectrometry analysis of cellular and tissue medium- and ongchain acyl-coenzyme A thioesters. Rapid Commun Mass Spectrom . 2014 Aug 30; 28(16):1840 – 1848. PMCID: PMC4286313

Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, Jackson E, Aiello NM, Haas NB, Rebbeck TR, Judkins A, Won KJ, Chodosh LA, Garcia BA, Stanger BZ, Feldman MD, Blair IA, Wellen KE Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation Cell Metab. 2014 Aug 5; 20(2):306-19. PMCID: PMC4151270

Huang M, Zhang L, Mesaros C, Zhang S, Blaha MA, Blair IA, Penning TM. Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells. Chem Res Toxicol 2015 Oct 19; 27(5):852-63. PMCID: PMC4028327

Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA. The aspartate metabolism pathway is differentiable in human hepatocellular carcinoma: transcriptomics and (13) C-isotope based metabolomics. NMR Biomed. 2014 Apr; 27(4):381-9. PMID: 24497316; PMCID: PMC3962779.

Summers CM, Hammons AL, Arora J, Zhang S, Jochems J, Blair IA, Whitehead AS. Methotrexate modulates folate phenotype and inflammatory profile in EAhy 926 cells. Eur J Pharmacol. 2014 Jun 5; 732:60-7. PMID: 24657277; PMCID: PMC4402228.

2013

Basu SS, Deutsch EC, Schmaier AA, Lynch DR, Blair IA. Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS. Bioanalysis. 2013 Dec; 5(24):3009-21. PMID: 24320127; PMCID: PMC3912754.

Berman A, Turowski J, Mick R, Cengel K, Farnese N, Basel-Brown L, Mesaros C, Blair I, Lawson J, Christofidou-Solomidou M, Lee J, and Rengan R. Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation. J Pulm Respir Med 2013, 3:4 1000154. PMCID: PMC3932620

Baldwin DA, Sarnowski CP, Reddy SA, Blair IA, Clapper M, Lazarus P, Li M, Muscat JE, Penning TM, Vachani A, Whitehead AS. Development of a genotyping microarray for studying the role of gene-environment interactions in risk for lung cancer. J Biomol Tech. 2013 Dec; 24(4):198-217. PMCID:PMC3792704

Zhang L, Huang M, Blair IA, Penning TM. Interception of Benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGT) in Human Lung Cells. Chem Res Toxicol. 2012 Aug 24; 26(10):1570-8. PMCID: PMC3829198

Snyder NW, Revello SD, Liu X, Zhang S, Blair IA. Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid. J Lipid Res. 2013 Nov; 54(11):3070-7. PMID: 23945567; PMCID: PMC3793611.

Tamae D, Byrns M, Marck B, Mostaghel EA, Nelson PS, Lange P, Lin D, Taplin ME, Balk S, Ellis W, True L, Vessella R, Montgomery B, Blair IA, Penning TM. Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum. J Steroid Biochem Mol Biol. 2013 Nov; 138:281-9. PMID: 23851165; PMCID: PMC3866616

Huang M, Blair IA, Penning TM. Identification of stable benzo[a]pyrene-7,8-dione-DNA adducts in human lung cells. Chem Res Toxicol. 2013 May 20; 26(5):685-92. PMID: 23587017; PMCID: PMC3660951.

Lee I, Dodia C, Chatterjee S, Zagorski J, Mesaros C, Blair IA, Feinstein SI, Jain M, Fisher AB. A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung. J Pharmacol Exp Ther. 2013 May; 345(2):284-96. PMID: 23475902; PMCID: PMC3629794.

Strasser AA, Ashare RL, Kaufman M, Tang KZ, Mesaros AC, Blair IA. The effect of menthol on cigarette smoking behaviors, biomarkers and subjective responses. Cancer Epidemiol Biomarkers Prev. 2013 Mar; 22(3):382-9. PMID: 23334588; PMCID: PMC3596436.

Snyder NW, Khezam M, Mesaros CA, Worth A, Blair IA. Untargeted metabolomics from biological sources using ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). J Vis Exp. 2013 May 20; PMID: 23711563; PMCID: PMC3711276

2013

Basu SS, Deutsch EC, Schmaier AA, Lynch DR, Blair IA. Human platelets as a platform to monitor metabolic biomarkers using stable isotopes and LC-MS. Bioanalysis. 2013 Dec; 5(24):3009-21. PMID: 24320127; PMCID: PMC3912754.

Berman A, Turowski J, Mick R, Cengel K, Farnese N, Basel-Brown L, Mesaros C, Blair I, Lawson J, Christofidou-Solomidou M, Lee J, and Rengan R. Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation. J Pulm Respir Med 2013, 3:4 1000154. PMCID: PMC3932620

Baldwin DA, Sarnowski CP, Reddy SA, Blair IA, Clapper M, Lazarus P, Li M, Muscat JE, Penning TM, Vachani A, Whitehead AS. Development of a genotyping microarray for studying the role of gene-environment interactions in risk for lung cancer. J Biomol Tech. 2013 Dec; 24(4):198-217. PMCID:PMC3792704

Zhang L, Huang M, Blair IA, Penning TM. Interception of Benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGT) in Human Lung Cells. Chem Res Toxicol. 2012 Aug 24; 26(10):1570-8. PMCID: PMC3829198

Snyder NW, Revello SD, Liu X, Zhang S, Blair IA. Cellular uptake and antiproliferative effects of 11-oxo-eicosatetraenoic acid. J Lipid Res. 2013 Nov; 54(11):3070-7. PMID: 23945567; PMCID: PMC3793611.

Tamae D, Byrns M, Marck B, Mostaghel EA, Nelson PS, Lange P, Lin D, Taplin ME, Balk S, Ellis W, True L, Vessella R, Montgomery B, Blair IA, Penning TM. Development, validation and application of a stable isotope dilution liquid chromatography electrospray ionization/selected reaction monitoring/mass spectrometry (SID-LC/ESI/SRM/MS) method for quantification of keto-androgens in human serum. J Steroid Biochem Mol Biol. 2013 Nov; 138:281-9. PMID: 23851165; PMCID: PMC3866616

Huang M, Blair IA, Penning TM. Identification of stable benzo[a]pyrene-7,8-dione-DNA adducts in human lung cells. Chem Res Toxicol. 2013 May 20; 26(5):685-92. PMID: 23587017; PMCID: PMC3660951.

Lee I, Dodia C, Chatterjee S, Zagorski J, Mesaros C, Blair IA, Feinstein SI, Jain M, Fisher AB. A novel nontoxic inhibitor of the activation of NADPH oxidase reduces reactive oxygen species production in mouse lung. J Pharmacol Exp Ther. 2013 May; 345(2):284-96. PMID: 23475902; PMCID: PMC3629794.

Strasser AA, Ashare RL, Kaufman M, Tang KZ, Mesaros AC, Blair IA. The effect of menthol on cigarette smoking behaviors, biomarkers and subjective responses. Cancer Epidemiol Biomarkers Prev. 2013 Mar; 22(3):382-9. PMID: 23334588; PMCID: PMC3596436.

Snyder NW, Khezam M, Mesaros CA, Worth A, Blair IA. Untargeted metabolomics from biological sources using ultraperformance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). J Vis Exp. 2013 May 20; PMID: 23711563; PMCID: PMC3711276

2012

Gelhaus SL, Gilad O, Hwang WT, Penning TM, Blair IA. Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells. Toxicol Lett. 2012 Feb 25; 209(1):58-66. PMID: 22155354; PMCID: PMC3256298.

Wehr AY, Hwang WT, Blair IA, Yu KH. Relative quantification of serum proteins from pancreatic ductal adenocarcinoma patients by stable isotope dilution liquid chromatography-mass spectrometry. J Proteome Res. 2012 Mar 2; 11(3):1749-58. PMID: 22264027; PMCID: PMC3292696.

Mesaros C, Blair IA. Targeted chiral analysis of bioactive arachidonic Acid metabolites using liquid-chromatography-mass spectrometry. Metabolites. 2012 Apr 20; 2(2):337-65. PMID: 24957514; PMCID: PMC3901208.

Huang M, Liu X, Basu SS, Zhang L, Kushman ME, Harvey RG, Blair IA, Penning TM. Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct. Chem Res Toxicol. 2012 May 21; 25(5):993-1003. PMID: 22480306; PMCID: PMC3358497.

Mesaros C, Arora JS, Wholer A, Vachani A, Blair IA. 8-Oxo-2'-deoxyguanosine as a biomarker of tobacco-smoking-induced oxidative stress. Free Radic Biol Med. 2012 Aug 1; 53(3):610-7. PMID: 22613262; PMCID: PMC4283839.

Zhang L, Huang M, Blair IA, Penning TM. Detoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cells. J Biol Chem. 2012 Aug 24; 287(35):29909-20. PMID: 22782890; PMCID: PMC3436139.

Wu A, Xu D, Lu D, Penning TM, Blair IA, Harvey RG. Synthesis of 13C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene. Tetrahedron. 2012 Sep 1; 68(35) PMID: 24244053; PMCID: PMC3826453.

Ashare RL, Tang KZ, Mesaros AC, Blair IA, Leone F, Strasser AA. Effects of 21 days of varenicline versus placebo on smoking behaviors and urges among non-treatment seeking smokers. J Psychopharmacol. 2012 Oct; 26(10):1383-90. PMID: 22695488; PMCID: PMC3526838.

Hood ED, Greineder CF, Dodia C, Han J, Mesaros C, Shuvaev VV, Blair IA, Fisher AB, Muzykantov VR. Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo. J Control Release. 2012 Oct 28; 163(2):161-9. PMID: 22974832; PMCID: PMC3495982.

MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG. Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissue. Mol Cell Proteomics. 2012 Dec; 11(12):1670-81. PMID: 22942359; PMCID: PMC3518127.

Hammons AL, Summers CM, Jochems J, Arora JS, Zhang S, Blair IA, Whitehead AS. Pemetrexed alters folate phenotype and inflammatory profile in EAhy 926 cells grown under low-folate conditions. Eur J Pharmacol. 2012 Dec 5; 696(1-3):12-7. PMID: 22975265; PMCID: PMC4051202.

2011

Fong KP, Barry C, Tran AN, Traxler EA, Wannemacher KM, Tang HY, Speicher KD, Blair IA, Speicher DW, Grosser T, Brass LF. Deciphering the human platelet sheddome. Blood. 2011 Jan 6; 117(1):e15-26. PMID: 20962327; PMCID: PMC3037762.

Gelhaus SL, Harvey RG, Penning TM, Blair IA. Regulation of benzo[a]pyrene-mediated DNA- and glutathione-adduct formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human lung cells. Chem Res Toxicol. 2011 Jan 14;24(1):89-98. PMID: 21028851; PMCID: PMC3021323.

Bhat SH, Gelhaus SL, Mesaros C, Vachani A, Blair IA. A new liquid chromatography/mass spectrometry method for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine. Rapid Commun Mass Spectrom. 2011 Jan 15;25(1):115-21. PMID: 21154658; PMCID: PMC3348551.

Johnson TV, Gupta PK, Vudathala DK, Blair IA, Tanna AP. Thermal stability of bimatoprost, latanoprost, and travoprost under simulated daily use. J Ocul Pharmacol Ther. 2011 Feb;27(1):51-9. PMID: 21117945; PMCID: PMC3038126.

Basu SS, Mesaros C, Gelhaus SL, Blair IA. Stable isotope labeling by essential nutrients in cell culture for preparation of labeled coenzyme A and its thioesters. Anal Chem. 2011 Feb 15;83(4):1363-9. PMID: 21268609; PMCID: PMC3048769.

Rangiah K, Hwang WT, Mesaros C, Vachani A, Blair IA. Nicotine exposure and metabolizer phenotypes from analysis of urinary nicotine and its 15 metabolites by LC-MS. Bioanalysis. 2011 Apr;3(7):745-61. PMID: 21452992; PMCID: PMC3134267.

Wehr AY, Furth EE, Sangar V, Blair IA, Yu KH. Analysis of the human pancreatic stellate cell secreted proteome. Pancreas. 2011 May;40(4):557-66. PMID: 21499210; PMCID: PMC3086313.

Mitra R, Lee J, Jo J, Milani M, McClintick JN, Edenberg HJ, Kesler KA, Rieger KM, Badve S, Cummings OW, Mohiuddin A, Thomas DG, Luo X, Juliar BE, Li L, Mesaros C, Blair IA, Srirangam A, Kratzke RA, McDonald CJ, Kim J, Potter DA. Prediction of postoperative recurrence-free survival in non-small cell lung cancer by using an internationally validated gene expression model. Clin Cancer Res. 2011 May 1;17(9):2934-46. PMID: 21242119; PMCID: PMC3086939.

Rangiah K, Shah SJ, Vachani A, Ciccimaro E, Blair IA. Liquid chromatography/mass spectrometry of pre-ionized Girard P derivatives for quantifying estrone and its metabolites in serum from postmenopausal women. Rapid Commun Mass Spectrom. 2011 May 15;25(9):1297-307. PMID: 21488127; PMCID: PMC3732066.

Arora JS, Oe T, Blair IA. Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(<i>E</i>)-nonenal. J Labelled Comp Radiopharm. 2011 May 15;54(5):247-251. PMID: 25152561; PMCID: PMC4138879.

Mitra R, Guo Z, Milani M, Mesaros C, Rodriguez M, Nguyen J, Luo X, Clarke D, Lamba J, Schuetz E, Donner DB, Puli N, Falck JR, Capdevila J, Gupta K, Blair IA, Potter DA. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). J Biol Chem. 2011 May 20; 286(20):17543-59. PMID: 21402692; PMCID: PMC3093829.

Jin Y, Mesaros AC, Blair IA, Penning TM. Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway. Biochem J. 2011 Jul 1;437(1):53-61. PMID: 21521174; PMCID: PMC3825703.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475(7354):106-9. PMID: 21734707; PMCID: PMC3404470.

Zhang L, Jin Y, Chen M, Huang M, Harvey RG, Blair IA, Penning TM. Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols. J Biol Chem. 2011 Jul 22;286 (29):25644-54. PMID: 21622560; PMCID: PMC3138279.

Basu SS, Blair IA. Rotenone-mediated changes in intracellular coenzyme A thioester levels: implications for mitochondrial dysfunction. Chem Res Toxicol. 2011 Oct 17;24(10):1630-2. PMID: 21950265; PMCID: PMC3196242.

Gelhaus SL, Mesaros AC, Blair IA. Cellular lipid extraction for targeted stable isotope dilution liquid chromatography-mass spectrometry analysis. J Vis Exp. 2011 Nov 17;PMID: 22127066; PMCID: PMC3308612.

Lu D, Harvey RG, Blair IA, Penning TM. Quantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Chem Res Toxicol. 2011 Nov 21;24(11):1905-14. PMID: 21962213; PMCID: PMC3725129.

Speed N, Blair IA. Cyclooxygenase- and lipoxygenase-mediated DNA damage. Cancer Metastasis Rev. 2011 Dec;30(3-4):437-47. PMID: 22009064; PMCID: PMC3237763.

Basu SS, Blair IA. SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards. Nat Protoc. 2011 Dec 8;7(1):1-12. PMID: 22157971; PMCID: PMC3802537.

Liu X, Zhang S, Arora JS, Snyder NW, Shah SJ, Blair IA. 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid. Chem Res Toxicol. 2011 Dec 19; 24(12):2227-36. PMID: 21916491; PMCID: PMC3242474.

2010

Blair IA. Analysis of endogenous glutathione-adducts and their metabolites. Biomed Chromatogr. 2010 Jan;24(1):29-38. PMID: 20017120; PMCID: PMC3802536.

Ciccimaro E, Blair IA. Stable-isotope dilution LC–MS for quantitative biomarker analysis. Bioanalysis. 2010 Feb;2(2):311-41. PMID: 20352077; PMCID: PMC2843934.

Byrns MC, Duan L, Lee SH, Blair IA, Penning TM. Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):177-87. PMID: 20036328; PMCID: PMC2819162.

Mesaros C, Gugiu BG, Zhou R, Lee SH, Choi J, Laird J, Blair IA, Salomon RG. A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA. Chem Res Toxicol. 2010 Mar 15;23(3):516-27. PMID: 20131875; PMCID: PMC2848942.

Blair IA. Analysis of estrogens in serum and plasma from postmenopausal women: past present, and future. Steroids. 2010 Apr;75(4-5):297-306. PMID: 20109478; PMCID: PMC2840185.

Cooper PR, Mesaros AC, Zhang J, Christmas P, Stark CM, ouaidy K, Mittelman MA, Soberman RJ, Blair IA, Panettieri RA. 20-HETE mediates ozone-induced, neutrophil-independent airway hyper-responsiveness in mice. PLoS One. 2010 Apr 20;5(4):e10235. PMID: 20422032; PMCID: PMC2857875.

Kinder M, Wei C, Shelat SG, Kundu M, Zhao L, Blair IA, Puré E. Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood. 2010 Jun 17;115(24):5012-22. PMID: 20357242; PMCID: PMC2890149.

Summers CM, Mitchell LE, Stanislawska-Sachadyn A, Baido SF, Blair IA, Von Feldt JM, Whitehead AS. Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. Birth Defects Res A Clin Mol Teratol. 2010 Aug;88(8):679-88. PMID: 20544798; PMCID: PMC4051228.

Penning TM, Lee SH, Jin Y, Gutierrez A, Blair IA. Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications. J Steroid Biochem Mol Biol. 2010 Aug; 121(3-5):546-55. PMID: 20083198; PMCID: PMC2894289.

Kinder M, Thompson JE, Wei C, Shelat SG, Blair IA, Carroll M, Puré E. Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase-mediated redox signaling. Exp Hematol. 2010 Nov;38(11):1036-1046.e1-4. PMID: 20647030; PMCID: PMC2963586.

Mesaros C, Lee SH, Blair IA. Analysis of epoxyeicosatrienoic acids by chiral liquid chromatography/electron capture atmospheric pressure chemical ionization mass spectrometry using [13C]-analog internal standards. Rapid Commun Mass Spectrom. 2010 Nov 30;24 (22):3237-47. PMID: 20972997; PMCID: PMC3348553.

2009

Hahn CG, Banerjee A, Macdonald ML, Cho DS, Kamins J, Nie Z, Borgmann-Winter KE, Grosser T, Pizarro A, Ciccimaro E, Arnold SE, Wang HY, Blair IA. The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. PLoS One. 2009;4(4):e5251. PMID: 19370153; PMCID: PMC2666803.

Yang IY, Hashimoto K, de Wind N, Blair IA, Moriya M. Two distinct translesion synthesis pathways across a lipid peroxidation-derived DNA adduct in mammalian cells. J Biol Chem. 2009 Jan 2;284(1):191-8. PMID: 18981176; PMCID: PMC2610493.

Xu D, Penning TM, Blair IA, Harvey RG. Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer. J Org Chem. 2009 Jan 16;74(2):597-604. PMID: 19132942; PMCID: PMC3418794. (published prior to April 7, 2008)

Matthews RP, Lorent K, Mañoral-Mobias R, Huang Y, Gong W, Murray IV, Blair IA, Pack M. TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development. 2009 Mar;136(5):865-75. PMID: 19201949; PMCID: PMC2685951.

Yu KH, Barry CG, Austin D, Busch CM, Sangar V, Rustgi AK, Blair IA. Stable isotope dilution multidimensional liquid chromatography-tandem mass spectrometry for pancreatic cancer serum biomarker discovery. J Proteome Res. 2009 Mar;8(3):1565-76. PMID: 19199705; PMCID: PMC2652408.

Ciccimaro E, Hanks SK, Blair IA. Quantification of focal adhesion kinase activation loop phosphorylation as a biomarker of Src activity. Mol Pharmacol. 2009 Mar;75(3):658-66. PMID: 19098120; PMCID: PMC2684915.

Jin Y, Duan L, Lee SH, Kloosterboer HJ, Blair IA, Penning TM. Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism. J Biol Chem. 2009 Apr 10;284(15):10013-22. PMID: 19218247; PMCID: PMC2665056.

Ciccimaro E, Hanks SK, Yu KH, Blair IA. Absolute quantification of phosphorylation on the kinase activation loop of cellular focal adhesion kinase by stable isotope dilution liquid chromatography/mass spectrometry. Anal Chem. 2009 May 1;81(9):3304-13. PMID: 19354260; PMCID: PMC2706532.

Shah SJ, Yu KH, Sangar V, Parry SI, Blair IA. Identification and quantification of preterm birth biomarkers in human cervicovaginal fluid by liquid chromatography/tandem mass spectrometry. J Proteome Res. 2009 May;8(5):2407-17. PMID: 19271751; PMCID: PMC2729452.

Mangal D, Vudathala D, Park JH, Lee SH, Penning TM, Blair IA. Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress. Chem Res Toxicol. 2009 May;22(5):788-97. PMID: 19309085; PMCID: PMC2684441.

Weibel GL, Joshi MR, Alexander ET, Zhu P, Blair IA, Rothblat GH. Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport. Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):837-42. PMID: 19325142; PMCID: PMC2759530.

Jian W, Lee SH, Williams MV, Blair IA. 5-Lipoxygenase-mediated endogenous DNA damage. J Biol Chem. 2009 Jun 19;284(25):16799-807. PMID: 19390118; PMCID: PMC2719316.

Lu ZY, Jensen LE, Huang Y, Kealey C, Blair IA, Whitehead AS. The up-regulation of monocyte chemoattractant protein-1 (MCP-1) in Eahy 926 endothelial cells under long-term low folate stress is mediated by the p38 MAPK pathway. Atherosclerosis. 2009 Jul;205(1):48-54. PMID: 19152916; PMCID: PMC2715998.

Lee SH, Blair IA. Targeted chiral lipidomics analysis of bioactive eicosanoid lipids in cellular systems. BMB Rep. 2009 Jul 31;42(7):401-10. PMID: 19643036; PMCID: PMC4063125.

Mitchell LE, Morales M, Khartulyari S, Huang Y, Murphy K, Mei M, Von Feldt JM, Blair IA, Whitehead AS. Folate and homocysteine phenotypes: Comparative findings using research and clinical laboratory data. Clin Biochem. 2009 Aug;42(12):1275-81. PMID: 19427846; PMCID: PMC4051207.

Wei C, Zhu P, Shah SJ, Blair IA. 15-oxo-Eicosatetraenoic acid, a metabolite of macrophage 15-hydroxyprostaglandin dehydrogenase that inhibits endothelial cell proliferation. Mol Pharmacol. 2009 Sep;76(3):516-25. PMID: 19535459; PMCID: PMC2730384.

Mesaros C, Lee SH, Blair IA. Targeted quantitative analysis of eicosanoid lipids in biological samples using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2736-45. PMID: 19345647; PMCID: PMC2745066.

Zhu P, Jian W, Blair IA. A 4-oxo-2(E)-nonenal-derived glutathione adduct from 15-lipoxygenase-1-mediated oxidation of cytosolic and esterified arachidonic acid. Free Radic Biol Med. 2009 Oct 1;47(7):953-61. PMID: 19576981; PMCID: PMC2777738.

Park JH, Mangal D, Frey AJ, Harvey RG, Blair IA, Penning TM. Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione. J Biol Chem. 2009 Oct 23;284(43):29725-34. PMID: 19726680; PMCID: PMC2785604.

Rangiah K, Tippornwong M, Sangar V, Austin D, Tétreault MP, Rustgi AK, Blair IA, Yu KH. Differential secreted proteome approach in murine model for candidate biomarker discovery in colon cancer. J Proteome Res. 2009 Nov;8(11):5153-64. PMID: 19769411; PMCID: PMC2786478.

Savitski AN, Mesaros C, Blair IA, Cohen NA, Kreindler JL. Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. Respir Res. 2009 Nov 27;10:120. PMID: 19943936; PMCID: PMC2792224.

Middleton MK, Zukas AM, Rubinstein T, Kinder M, Wilson EH, Zhu P, Blair IA, Hunter CA, Puré E. 12/15-lipoxygenase-dependent myeloid production of interleukin-12 is essential for resistance to chronic toxoplasmosis. Infect Immun. 2009 Dec;77(12):5690-700. PMID: 19822654; PMCID: PMC2786478.

Weibel GL, Joshi MR, Wei C, Bates SR, Blair IA, Rothblat GH. 15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism. J Lipid Res. 2009 Dec;50(12):2371-6. PMID: 19528634; PMCID: PMC2781309.

2008

Zhu P, Oe T, Blair IA. Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide. Rapid Commun Mass Spectrom. 2008; 22(4):432-40. PMID: 18215009. (Jan 2008; published prior to April 7, 2008)

Ran C, Dai Q, Ruan Q, Penning TM, Blair IA, Harvey RG. Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides. J Org Chem. 2008 Feb 1; 73(3):992-1003. PMID: 18181642. (published prior to April 7, 2008)

Shultz CA, Palackal NT, Mangal D, Harvey RG, Blair IA, Penning TM. Fjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preference. Chem Res Toxicol. 2008 Mar; 21(3):668-77. PMID: 18251511; PMCID: PMC2440589.

Xu D, Duan Y, Blair IA, Penning TM, Harvey RG. Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues. Org Lett. 2008 Mar 20; 10(6):1059-62. PMID: 18284245.

Park JH, Gelhaus S, Vedantam S, Oliva AL, Batra A, Troxel AB, Field J, Penning TM.. The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance. Chem Res Toxicol. 2008 May; 21(5):1039-49. PMID: 18489080; PMCID: PMC2671329.

Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, Fitzgerald GA, Grosser T. Analysis of the zebrafish proteome during embryonic development. Mol Cell Proteomics. 2008 May; 7(5):981-94. PMID: 18212345; PMCID: PMC2401336.

Park JH, Mangal D, Tacka KA, Quinn AM, Harvey RG, Blair IA, Penning TM. Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6846-51. PMID: 18474869; PMCID: PMC2383938.

Blair IA. DNA adducts with lipid peroxidation products. J Biol Chem. 2008 Jun 6; 283(23):15545-9. PMID: 18285329; PMCID: PMC2414303.

Ran C, Xu D, Dai Q, Penning TM, Blair IA, Harvey RG. Synthesis of 13C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites. Tetrahedron Lett. 2008 Jul 21; 49(29-30):4531-4533. PMID: 24155502; PMCID: PMC3804341.

Huang Y, Khartulyari S, Morales ME, Stanislawska-Sachadyn A, Von Feldt JM, Whitehead AS, Blair IA. Quantification of key red blood cell folates from subjects with defined MTHFR 677C&gt;T genotypes using stable isotope dilution liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom. 2008 Aug; 22(16):2403-12. PMID: 18634122; PMCID: PMC4400668.

Lu ZY, Morales M, Khartulyari S, Mei M, Murphy KM, Stanislawska-Sachadyn A, Summers CM, Huang Y, Von Feldt JM, Blair IA, Mitchell LE, Whitehead AS. Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. Birth Defects Res A Clin Mol Teratol. 2008 Oct; 82(10):736-41. PMID: 18937353; PMCID: PMC3014088.

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