Brass Lab


TJ Stalker, JD Welsh, M Tomaiuolo, J Wu, TV Colace, SL Diamond and LF Brass. A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity. Blood 124:1824-1831, 2014.

M Tomaiuolo, TJ Stalker, JD Welsh, SL Diamond, T Sinno and LF Brass. A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood 124:1816-1823, 2014.

JD Welsh, TJ Stalker, R Voronov, RW Muthard, M Tomaiuolo, SL Diamond and LF Brass. A systems approach to hemostasis: 1. The interdependence of thrombus architecture, agonist concentration gradients and the movement of molecules in the gaps between platelets. Blood 124:1808-1815, 2014.

TJ Stalker, JD Welsh and LF Brass. Shaping the platelet response to vascular injury. Curr. Opin. Hematol. 21: 410-417, 2014. PMID: 25023471.

LF Brass M. Tomaiuolo and TJ Stalker. Harnessing the platelet signaling network to produce an optimal hemostatic response. Hematol Clin North Am 27: 381-409, 2013. PMID: 23714305.

Lu Q, Dong N, Wang Q, Yi W, Wang Y, Zhang S, Gu H, Zhao X, Tang X, Jin B, Wu Q, Brass LF, Zhu L. Increased levels of plasma soluble sema4D in patients with heart failure. PLoS One e64265, 2013. PMID: 23741311.

P. Mou, Z. Zeng, Q. Li, X. Liu, X. Xin, K.M. Wannemacher, C. Ruan, R. Li, L.F. Brass and L. Zhu. Identification of a Calmodulin-binding Domain in Sema4D that Regulates its Exodomain Shedding in Platelets. Blood 121: 4221-4230, 2013. PMID: 23564909

R.S. Voronov, T.J. Stalker, L.F. Brass and S.L. Diamond. Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution. Ann. Biomed. Engineering 41:1297-307, 2013. PMID: 23423707

T.J. Stalker, E.A. Traxler, J. Wu, K.M. Wannemacher, S.L. Cermignano, R. Voronov, S.L. Diamond and L.F. Brass. Hierarchical organization in the hemostatic response and its relationship to the platelet signaling network. Blood 121: 1875-85, 2013. PMID: 23303817

J.H. Welsh, T.V. Colace, R.W. Muthard, T.J. Stalker, L.F. Brass and S.L. Diamond. Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse. J. Thromb. Haemostas. 10: 2344-53, 2012. PMID 22978514.

M.H. Flamm, T. Colace, M.S. Chatterjee, H. Jing, S. Zhou, D. Jaeger, L.F. Brass, T. Sinno, S.L. Diamond. Multiscale prediction of patient-specific platelet function under flow. Blood 120:190-8, 2012. PMID: 22517902.

M.U. Naik, T.J. Stalker, L.F. Brass and U.P. Naik, JAM-A protects from thrombosis by suppressing integrin aIIbb3  outside-in signaling in platelets. Blood 119:3352-3360, 2012. PMID: 22271446.

P. Ma, A. Cierniewska, R. Signarvic, M. Cieslak, H. King, A.J. Sinnamon, R.R. Neubig, D.K. Newman, T.J. Stalker and L.F. Brass, A newly-identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein dependent signaling. Blood 119: 1935-45, 2012. PMID: 22210881

Dooyoung Lee, Karen P. Fong, Michael R. King, Lawrence F. Brass and Daniel A. Hammer. Differential dynamics of platelet contacts and spreading. Biophys. J.  102: 472-482, 2012. PMID: 22325269.

A. Schmaier, T. Stalker, J. Runge, D. Lee, C. Nagaswami, P. Mericko, M. Chen, S. Cliché, C. Gariepy, L. Brass, D. Hammer, J. Weisel, K. Rosenthal and M. Kahn. Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human CV disease. Blood 118: 3661-9, 2011. PMID: 21816834.

Wannemacher, K.M., Wang, L., Zhu, L. and Brass, L.F. The role of semaphorins and their receptors in platelets: lessons learned from neuronal and immune synapses. Platelets 22:461-5, 2011. PMID: 21668292.

L.F. Brass, K.M. Wannemacher, P. Ma and T.J. Stalker, Regulating thrombus growth and stability to achieve an optimal response to injury.  J. Thromb. Haemostas. 9, Suppl.1, 66-75, 2011. PMID: 21781243.

K.P. Fong, C. Barry,  A.N. Tran, E.A. Traxler, K.M. Wannemacher, H.-Y. Tang, K.D. Speicher, I. A. Blair, D.W. Speicher, T. Grosser and L.F. Brass. Deciphering the human sheddome. Blood. 2011 Jan 6;117(1):e15-26. PMID: 20962327.

R.S. Signarvic, A. Cierniewska, T.J. Stalker, K.P Fong, M.S. Chatterjee, P.R. Hess, P. Ma, S.L. Diamond, R.R. Neubig and L.F. Brass. RGS/Gi2a interactions modulate platelet accumulation and thrombus formation at sites of vascular injury. Blood. 2010 Dec 23;116(26):6092-100. PMID: 20852125.

K.M. Wannemacher, L. Zhu, H. Jiang, K.P. Fong, T.J. Stalker, D. Lee, A. Tran, K.B. Neeves, S. Maloney, A. Kumanogoh, H. Kikutani, D. Hammer, S. Diamond and L. Brass. Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking sema4D. Blood. 2010 Dec 16;116(25):5707-15. PMID: 20855865.

S.F. Maloney, L.F. Brass and S.L. Diamond. P2Y12 and P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. Integr. Biol. 2: 1831-92, 2010. PMID: 20473398.

M. Chatterjee, J. Purvis, L.F. Brass and S.L. Diamond. Pairwise Agonist Scanning of human platelets reveals the high-dimensional calcium response to combinatorial mediators of thrombosis. Nature Biotechnology 28: 727-732, 2010. PMID: 20562863.

L. F. Brass, , M. H. Akabas, L. D. Burnley, D. M. Engman, C. A. Wiley and O. S. Andersen. Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.  Academic Medicine 85: 692-701, 2010. PMID: 20186033.

L. Zhu, T.J. Stalker, K.P. Fong, H. Jiang, A. Tran, I. Crichton, E.K. Lee, K.B. Neeves, S.F. Maloney, H. Kikutani, A. Kumanogoh, E. Pure, S.L. Diamond and L.F. Brass. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler. Thromb. and Vasc. Biol. 29: 1039-1045, 2009. PMID: 19390055.

T.J. Stalker, J. Wu, A. Morgans, T. Quertermous, R.A. Hall and L.F. Brass,  The CTX family member, ESAM, is a negative regulator of thrombus growth in vivo. . J. Thromb. Hemostas. 7:1886-96, 2009. PMID: 19740102.

Y. Wang, X. Chen, L. Lian, T. Tang. T.J. Stalker, T. Sasaki, L.F. Brass, J. Choi, MJ. Hartwig, and C. S. Abrams. Loss of PIP5KIb demonstrates that PIP5KI isoform-specific PIP2 synthesis s required for IP3 formation.  PNAS 105: 14064-14069, 2008. PMID: 18772378.

J. E. Purvis, M. S. Chatterjee, L.F. Brass and S. L. Diamond. A molecular signaling model of platelet phosphoinositide hydrolysis and calcium regulation during homeostasis and P2Y1 activation.  Blood, 1122: 4069-4079, 2008. PMID: 18596227.

L. Zhu, W. Bergmeier, J. Wu, H. Jiang, M. Cieslak, R. Fan, L. Boumsell, A. Kumanogoh, L. Tamagnone, D. Wagner, M. Milla, L. Brass:  Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proc. Nat. Acad. Sci, 104: 1621-1626, 2007. PMID: 17244710

© The Trustees of the University of Pennsylvania | Site best viewed in a supported browser. | Report Accessibility Issues and Get Help | Privacy Policy | Site Design: PMACS Web Team.