Confocal micrograph illustrating high levels of TACI on an extra-follicular foci (splenic sections stained with PNA, TACI, B220)
Confocal micrograph showing the absence of BLyS from the germinal center (splenic sections stained with PNA, BLyS, CD3ε)
Confocal micrograph illustrating the anatomical location of germinal centers at the T-B border (PNA+ germinal center , CD3ε+ T, IgD+ B cells)
Confocal micrograph illustrating splenic architecture with MOMA-1+ macrophage layer seperating Marginal zone B cells (IgMhiIgDlo) from the Follicular B cells (IgMloIgDhi)
Our laboratory is currently pursuing studies focused on mechanisms of B cell homeostasis and how these impact autoimmunity and aging. These have led to the characterization of a novel receptor for BLyS, a TNF family member that controls B cell numbers and determines the stringency of B cell selection.