Our group is investigating T1ρ (“T-one-rho”) MRI as an endogenous contrast method for quantitative non-invasive imaging of myocardial injury. In comparison to T2 and native T1, T1ρ permits better detectability of myocardial fibrosis with improved specificity. Our research is investigating the origins of endogenous contrast in myocardium, fibrosis detection in large animal models of ischemia reperfusion and in patient studies. Our recent work developed new methods for imaging infiltrative fibrosis in hypertrophic cardiomyopathy and early studies demonstrating the potential for detection of interstitial disease.

Quantitative Susceptibility Mapping (QSM) is a new MRI technique that permits noninvasive assessment of the magnetic susceptibility of tissues and can target tissue iron. MRI imaging of myocardial magnetic susceptibility can show abnormal metabolism of iron in cardiovascular disease, aging, or during development. QSM is a challenging mathematical inverse problem. MRI can measure the induced magnetization in tissues, which is proportional to applied magnetic field. By measuring the induced magnetization, we can uncover the tissue magnetic susceptibility by solving the inverse problem.

quantitative susceptibility mapping
Quantitative susceptibility mapping of reperfusion injury