Penn Center for Perioperative Outcomes Research and Transformation

Center for Perioperative Outcomes Research and Transformation

What We Do

CPORT serves as a nucleus of expertise and effort related to perioperative health services research, to provide educational and mentoring opportunities for interested trainees and early-career faculty, and to facilitate collaboration across multiple disciplines to improve perioperative outcomes through high-quality comparative effectiveness research and implementation science.

Selected CPORT Research

REGAIN (Regional versus General Anesthesia for Promoting Independence after Hip Fracture Surgery)

Principal Investigator: Mark D. Neuman, MD, MSc

Funding: Patient-Centered Outcomes Research Institute, Washington DC


Summary: The REGAIN trial is a multicenter randomized trial to compare short- and long-term outcomes of two common approaches to anesthesia for patients undergoing surgery for hip fracture. By comparing two universally available, basic anesthetic approaches, the REGAIN trial will directly and immediately affect patient decision making, care, and outcomes for the more than 300,000 US patients who need surgery to treat hip fractures each year, as well as the more than 8.5 million older US adults who face decisions about anesthesia for other major surgeries each year.

The REGAIN Trial was mentioned in Congress in testimony on reauthorization of the Patient-Centered Outcomes Research Institute (PCORI).  See the video here.

Want to learn more? Click here to listen to a podcast of Dr. Mark Neuman and Lakisha Gaskins discussing their real-world experiences in designing and running the REGAIN trial.

Radiology Firing Line Episode (podcast) used with permission from the American College of Radiology.



HATRICC (Handoffs and Transitions in Critical Care)

Principal Investigator: Meghan Lane-Fall, MD, MSHP, FCCM

Funding: Anesthesia Patient Safety Foundation, Robert Wood Johnson Foundation


Summary: HATRICC is an ongoing multicenter study to improve handoffs from the operating room to the intensive care unit. Using qualitative and quantitative research methods, HATTRIC will lend insight into the quality of current handoff practices and the effectiveness of a structured approach to improving peri-procedural communication for patients requiring critical care.


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