Perelman School of Medicine at the University of Pennsylvania

Case Studies in Translational Research

Header Image

Syllabus & Reading Materials | Fall 2026


Date Faculty Preceptor Assigned Reading
Wednesday, September 9 Tal Zaks, MD, PhD

Three-Year Update of a Randomized Phase IIb Study of the Individualized Neoantigen Therapy Intismeran Autogene (mRNA-4157, V940) Plus Pembrolizumab Versus Pembrolizumab in Resected Melanoma

RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

Friday, September 11 Drew Weissman, MD, PhD

Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease

In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus

Wednesday, September 16 Kathy High, MD  
Wednesday, September 30 Carl June, MD

GPC3-specific dnTGFβRII-armoured CAR T cells for hepatocellular carcinoma

CAR T therapy beyond cancer: the evolution of a living drug

Wednesday, October 7 Ali Naji, MD, PhD

Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression

Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes

Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient

Wednesday, October 14 Paul Offit, MD

Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults

Wednesday, October 21 Nicola Mason, BVetMed, PhD, DACVIM, FRCVS

Immunological responses and clinical outcomes in dogs with osteosarcoma receiving standard therapy and a Listeria vaccine expressing HER2

A Novel Human Her-2/neu ChimericMolecule Expressed by Listeriamonocytogenes Can Elicit Potent HLA-A2 Restricted CD8-positive T cell Responses and Impact the Growth and Spread of Her-2/neu-positive Breast Tumors

Safety evaluation of the canine osteosarcoma vaccine, live Listeria vector

Monday, November 2 Jake Brenner, MD, PhD

Safer non-viral DNA delivery using lipidnanoparticles loaded with endogenousanti-inflammatory lipids

Targeting DNA-LNPs to Endothelial Cells ImprovesExpression Magnitude, Duration, and Specificity

Wednesday, November 4 Peter Lebowitz, MD, PhD

RIPTACs: A Groundbreaking Approach to Drug Discovery

Degrader-antibody conjugates

Wednesday, November 11 Christina Coughlin, MD, PhD