Publications

103. O'Donnell JC, Purvis EM, Helm KVT, Adewole DO, Zhang Q, Le AD, Cullen DK. An Implantable Human Stem Cell-Derived Tissue-Engineered Rostral Migratory Stream for Directed Neuronal Replacement, Communications Biology July 15 (2021).

102. Keating CE, Browne KD, Cullen DK. Dietary Manipulation of Vulnerability to Traumatic Brain Injury-Induced Neuronal Plasma Membrane Permeability, Experimental Neurology Feb 16 (2021).

101. Katiyar KS, Burrell JC, Laimo FA, Browne KD, Bianchi JR, Walters A, Ayares DL, Smith DH, Ali ZS, Ledebur HC, Cullen DK. Biomanufacturing of Axon-Based Tissue Engineered Nerve Grafts Using Porcine Galsafe Neurons, Tissue Engin Part A Jan 11 (2021).

100. Sullivan PZ, AlBayar A, Burrell JC, Browne KD, Arena J, Johnson VE, Smith DH, Cullen DK, Ozturk AK. Implantation of Engineered Axon Tracts to Bridge Spinal Cord Injury Beyond the Glial Scar in Rats, Tissue Engin Part A Jan 11 (2021).

99. Keating CE and Cullen DK. Mechanosensation in Traumatic Brain Injury, Neurobiology of Disease Nov 24 (2020).

98. Adewole DO, Struzyna LA, Harris JP, Nemes AD, Burrell JC, Petrov D, Kraft RH, Chen HI, Serruya MD, Wolf JA, Cullen DK. Development of Optically-Controlled "Living Electrodes" with Long-Projecting Axon Tracts for a Synaptic Brain-Machine Interface, Science Advances Jan 22, 7:4 (2021) [pre-published on bioRxiv 333526 (2018)].

97. Maggiore JC, Burrell JC (cfa), Browne KD, Katiyar KS, Laimo FA, Zarina AS, Kaplan HM, Rosen JM, Cullen DK. Tissue Engineered Axon-Based “Living Scaffolds” Promote Survival of Spinal Cord Motor Neurons Following Peripheral Nerve Repair, J Tissue Eng & Regen Med Oct 2, 1-16 (2020) [pre-published on bioRxiv 847988 (2019)].

96. Panzer KV, Burrell JC (cfa), Helm KVT, Purvis EM, Zhang Q, Le AD, O’Donnell JC, Cullen DK. Tissue Engineered Bands of Büngner for Accelerated Motor and Sensory Axonal Outgrowth, Frontiers in Bioeng and Biotech, section Tissue Engin and Regen Med Sept 28 (2020).

95. Burrell JC, Bhatnagar D, Brown DP, Murthy NS, Dutton J, Browne KD, Laimo FA, Ali ZS, Rosen JM, Kaplan HM, Kohn J, Cullen DK. Tyrosine-Derived Polycarbonate Nerve Guidance Tubes Elicit Pro-Regenerative Extracellular Matrix Deposition When Used to Bridge Segmental Nerve Defects in Swine, J Biomed Mat Res: Part A Sept 26 (2020) [pre-published on bioRxiv 902007 (2020)].

94. Huber CM, Patton DA, Wofford KL, Margulies SS, Cullen DK, Arbogast KB. Laboratory Assessment of a Headband-Mounted Sensor for Measurement of Head Impact Rotational Kinematics, J Biomech Engin Aug 19 (2020).

93. Clark EM, O’Donnell JC, Struzyna LA, Chen HI, Duda JE, Cullen DK, Engineered Microtissue as an Anatomically-Inspired Model of Parkinson’s Disease, Current Opinions in Biomed Engin July 28 (2020).

92. Jgamadze D, Johnson VE, Wolf JA, Cullen DK, Song H, Ming G, Smith DH, Chen HI. Modeling Traumatic Brain Injury with Human Brain Organoids, Current Opinions in Biomed Engin, May 24 (2020).

91. Das S, Browne KD, Laimo FA, Maggiore JC, Hilman MC, Kaiser H, Aguilar CA, Ali ZS, Mourkioti F, Cullen DK. Pre-Innervated Tissue Engineered Muscle Promotes a Pro-Regenerative Microenvironment Following Volumetric Muscle Loss, Nature Communications Biology May 20 (2020) [pre-published on bioRxiv 840124 (2019)].

90. Katiyar KS, Struzyna LA (cfa), Morand JP, Burrell JC, Clements B, Laimo FA, Browne KD, Kohn J, Ali Z, Ledebur HC, Smith DH, Cullen DK. Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats, Frontiers in Biotechnology & Bioengineering April 24 (2020) [pre-published on bioRxiv 654723 (2019)].

89. Das S, Gordián-Vélez W (cfa), Ledebur HC, Mourkioti F, Rompolas P, Chen HI, Serruya MD, Cullen DK. Innervation: The Missing Link for Biofabricated Tissues and Organs, npj Regenerative Medicine Apr 15 (2020).

88. Purvis EM, O’Donnell JC, Chen HI, Cullen DK, Tissue Engineering and Biomaterial Strategies to Elicit Endogenous Neuronal Replacement in the Brain, Frontiers in Neurology, section Neurorehabilitation Apr 28 (2020).

87. Burrell JC, Browne KD (cfa), Dutton JL, Das S, Brown DP, Laimo FA, Roberts S, Petrov D, Ali ZS, Ledebur HC, Rosen JM, Kaplan HM, Wolf JA, Smith DH, Chen HI, Cullen DK. A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance, Neurosurg Feb 11 (2020) [pre-published on bioRxiv 610147 (2019)].

86. Marinov T, Yuchi L, Adewole DO, Cullen DK, Kraft RH. A Computational Model of Bidirectional Axonal Growth in Micro-Tissue Engineered Neuronal Networks (micro-TENNs), In Silico Biology Feb 9 (2020) [pre-published on bioRxiv 369843 (2018)].

85. Keating CE, Browne KD, Duda JE, Cullen DK. Neurons in Subcortical Oculomotor Regions are Vulnerable to Plasma Membrane Damage after Repetitive Diffuse Traumatic Brain Injury in Swine, J Neurotrauma Feb 5 (2020).

84. Grovola MR, Paleologos N, Wofford KL, Harris JP, Browne KD, Johnson VE, Duda JE, Wolf JA, Cullen DK. Mossy Cell Hypertrophy and Synaptic Changes in the Hilus Following Mild Diffuse Brain Injury in Pigs, J Neuroinflammation 17(1), 44 (2020).

83. Wofford KL, Singh BS, Cullen DK, Spiller KL. Biomaterials-Based Reprogramming of Monocytes via Microparticle Phagocytosis for Sustained Modulation of Macrophage Phenotype, Acta Biomaterialia Jan 1; 1001:237-248 (2020), PMID: 31731024 [pre-published on bioRxiv 674598 (2019)].

82. Xu ZX, Albayar A, Dolle JP, Hansel G, Bianchini J, Sullivan PZ, Cullen DK, Smith DH, Ozturk AK. Dorsal Root Ganglion Axons Facilitate and Guide Cortical Neural Outgrowth: In Vitro Modeling of Spinal Cord Injury Axonal Regeneration, Restor Neurol Neurosci, Sept 28 (2019).

81. Cullen DK, Gordián-Vélez WJ, Struzyna LA, Jgamadze D, Lim J, Wofford KL, Browne KD, Chen HI. Bundled Three-Dimensional Human Axon Tracts Derived from Cerebral Organoids, iScience (2019), pre-published on bioRxiv 253369 (2018).

80. Katiyar KS, Lin A, Fridman A, Keating CE, Cullen DK and Miller V (co-senior author). Non-Thermal Plasma Accelerates Astrocyte Regrowth and Neurite Regeneration Following Physical Trauma In Vitro, Applied Sciences 9(18):3747 (2019).

79. Katiyar KS, Struzyna LA, Das S, Cullen DK. “Stretch-Growth” of Motor Axons in Custom Mechanobioreactors to Generate Long-Projecting Axonal Constructs, J Tissue Engin & Regen Med Nov; 13(11):2040-2054 (2019), PMID: 31469944

78. Harris JP, Burrell JC, Struzyna LS, Chen HI, Serruya MD, Wolf JA, Duda JE, Cullen DK. Emerging Regenerative Medicine and Tissue Engineering Strategies for Parkinson’s Disease, npj Parkinson’s Disease Jan 8; 6:4 (2020). PMID: 31934611.

77. Shin M, Song KH, Burrell JC, Cullen DK, Burdick JA. Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support, Advanced Science Aug 21; 6(20):1901229 (2019), PMID: 31637164.

76. Ulyanova AV, Cottone C, Adam CD, Gagnon KG, Cullen DK, Holtzman T, Jameison B, Koch PF, Chen HI, Johnson VE, Wolf JA. Multichannel Silicon Probes for Awake Hippocampal Recordings in Large Animals, Frontiers in Neuroscience, section Neural Technology Apr 26:13:397 (2019). PMID: 31080400.

75. Adewole DO, Serruya MD, Wolf JA, Cullen DK, Bioactive Neuroelectronic Interfaces, Frontiers in Neuroscience, section Neuroprosthetics, March 29; 13:269 (2019). PMID: 30983957.

74. Wofford KL, Loane DJ, Cullen DK. Acute Drivers of Neuroinflammation in Traumatic Brain Injury, Neural Regeneration Research 14(9):1481-1489 (2019). PMID: 31089036.

73. Adewole DO, Das S, Petrov D, Cullen DK, Scaffolds for Brain Tissue Reconstruction, Handbook of Tissue Engineering Scaffolds: Volume 2, ed. Atala T, 3-29 (2019).

72. Wofford KL, Cullen DK, Spiller KL. Modulation of Macrophage Phenotype via Phagocytosis of Drug-Loaded Microparticles, Journal of Biomedical Materials Research: Part A Jan 22 (2019). PMID: 30672109

71. Katiyar KS, Das S, Burrell JC, Cullen DK. Scaffolds for Bridging Sciatic Nerve Gaps, Handbook of Tissue Engineering Scaffolds: Volume 2, ed. Atala T, 67-93 (2019).

70. O’Donnell JC, Browne KD, Killbaugh TJ, Chen HI, Whyte J, Cullen DK. Challenges and Demand for Modeling Disorders of Consciousness following Traumatic Brain Injury, Neuroscience & Biobehavioral Reviews Mar;98:336-346 (2019). PMID: 30550859

69. Vitale F, Shen W, Driscoll N, Burrell JC, Richardson AG, Adewole DO, Murphy B, Ananthakrishnan A, Wang T, Lucas TH, Cullen DK, Allen MG, Litt B. Biomimetic Extracellular Matrix Coatings Improve the Chronic Biocompatibility of Microfabricated Subdural Microelectrode Arrays, PLOS ONE Nov 1;13(11):e0206137 (2018). PMID: 30383805

68. Philips BH, Browne KD, Cullen DK, Jaber SM. Rat Models of Central Nervous System Injury, The Laboratory Rat (3rd Edition) 1023-1075 (2020).

67. Driscoll N, Richardson AG, Maleski K, Anasori B, Adewole O, Lelyukh P, Escobedo L, Cullen DK, Lucas TH, Gogotsi Y, Vitale F. Two-Dimensional Ti3C2 MXene for High-Resolution Neural Interfaces, ACS Nano Oct 23; 12(10):10419-10429 (2018). PMID 30207690.

66. Shen W, Das S, Vitale F, Richardson A, Ananthakrishnan A, Struzyna LA, Brown DP, Song N, Ramkumar M, Lucas T, Cullen DK, Litt B, Allen MG. Microfabricated Intracortical Extracellular Matrix-Microelectrodes for Improving Neural Interfaces, “Feature Article” in Microsystems & Nanoengineering 4:30 (2018).

65. Dhobale AV, Adewole DO, Chan AHW, Marinov T, Serruya MD, Kraft RH, Cullen DK. Assessing Functional Connectivity Across Three-Dimensional Tissue Engineered Axonal Tracts Using Calcium Fluorescence Imaging, J Neural Engin 15(5):056008 (2018). PMID: 29855432.

64. O’Donnell JC, Katiyar KS, Panzer KV, Cullen DK. A Tissue-Engineered Rostral Migratory Stream for Directed Neuronal Replacement. Neural Regen Res 13(8):1327-1331 (2018). PMID: 30106034.

63. Bonder DE, Keating CE, Chandra N, Cullen DK, Pfister BJ. Modeling Traumatic Brain Injury In Vitro, Neuromethods in Pre-Clinical and Clinical Methods in Brain Trauma Research, June (2018).

62. Zhang Q, Nguyen PD, Shi S, Burrell JC, Cullen DK, Le AD. Three-Dimensional Bio-Printed Scaffold-Free Nerve Constructs with Human Gingiva-Derived Mesenchymal Stem Cells Promote Rat Facial Nerve Regeneration, Scientific Reports 8(1):6634 (2018). PMID: 29700345.

61. Struzyna LA, Browne KD, Brodnik ZD, Burrell JC, Harris JP, Chen HI, Wolf JA, Panzer KV, Lim J, Duda JE, España RA, Cullen DK. Tissue Engineered Nigrostriatal Pathway for Treatment of Parkinson’s Disease, J Tissue Engin & Regen Med 12(7): 1702-1716 (2018). PMID: 2976664.

60. Ulyanova AV, Koch PF (co-first author), Cottone C, Grovola MR, Adam CD, Browne KD, Weber M, Russo RJ, Gagnon K, Smith DH, Chen HI, Johnson VE, Cullen DK (co-senior author), Wolf JA. Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus, bioRxiv 201285 (2017) & eNeuro Sep 18;5(5)(2018).

59. Johnson VE, Weber MT, Xiao R, Cullen DK, Meaney DF, Stewart W, Smith DH. Mechanical Disruption of the Blood-Brain Barrier Following Experimental Concussion, Acta Neuropathol 135(5): 711-726 (2018). PMID: 29460006.

58. Zhang Q, Nguyen PD, Shi S, Burrell JC, Xu Q, Cullen DK, Le AD. Neural Crest Stem-Like Cells Non-Genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats, Molecular Neurobiology Jan 25: 1-19 (2018). PMID: 29372546.

57. Katiyar KS, Winter CC (cfa), Gordián-Vélez WJ, O’Donnell JC, Song YJ, Hernandez NS, Struzyna LA, Cullen DK. Three-Dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration, Journal of Visualized Experiments Jan 10:131 (2018).

56. Serruya MD, Harris JP, Adewole DO, Struzyna LA, Burrell JC, Nemes AD, Petrov D, Kraft RH, Chen HI, Wolf JA, Cullen DK. Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Modulation of Neural Circuitry, Advanced Functional Materials Sept 14: 1701183 (2017).

55. Wolf JA, Johnson BN, Johnson VE, Putt ME, Browne KD, Mietus CJ, Brown DP, Wofford KL, Smith DH, Grady MS, Cohen AS, Cullen DK. Concussion Induces Hippocampal Circuitry Disruption in Swine, J Neurotrauma Jul 15:34(14): 2303-14 (2017).

54. Struzyna LA, Adewole DO (cfa), Gordián-Vélez WJ, Grovola MR, Burrell JC, Katiyar KS, Petrov D, Harris JP, Cullen DK. Anatomically-Inspired Three-Dimensional Micro-Tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling, J Vis Exp May 31:123 (2017).

53. Wofford KL, Harris JP, Browne KD, Brown DP, Grovola MR, Mietus CJ, Wolf JA, Duda JE, Putt ME, Spiller KL, Cullen DK. Rapid Neuroinflammatory Response Localized to Injured Neurons After Diffuse Traumatic Brain Injury in Swine, Experimental Neurology 290:85-94 (2017). PMID 2808196352.

52. Roberts SE, Thibaudeau S, Burrell JC, Zager EL, Cullen DK, Levin LS. To Reverse or Not to Reverse? A Systematic Review of Autograft Polarity on Functional Outcomes following Peripheral Nerve Repair Surgery, Microsurgery 37(2):169-174 (2017). PMID 27935644

51. Adewole DO, Serruya MD, Harris JP, Burrell JC, Petrov D, Chen HI, Wolf JA, Cullen DK. The Evolution of Neuroprosthetic Interfaces, Critical Reviews in Biomedical Engineering 44(1-2):123-52 (2016).

50. Winter CC, Katiyar KS (co-first author), Hernandez NS, Song YJ, Struzyna LA, Harris JP, Cullen DK. Transplantable Living Scaffolds Comprised of Micro-Tissue Engineered Aligned Astrocyte Networks to Facilitate Central Nervous System Regeneration, Acta Biomaterialia 38:44-58 (2016).

49. Shen W, Struzyna LA, Cullen DK, Allen MG. Fabrication of Neural Microelectrode Arrays from Extracellular Matrix, Solid-State Sensors, Actuators, and Microsystems Technical Digest, Hilton Head Workshop (2016).

48. Katiyar KS, Winter CC, Struzyna LA, Harris JP, Cullen DK. Mechanical Elongation of Astrocyte Processes to Create Living Scaffolds for Nervous System Regeneration, J Tissue Engineering & Regenerative Medicine June 7 (2016).

47. Cullen DK, Harris JP, Browne KD, Wolf JA, Duda JE, Meaney DF, Margulies SS, Smith DH. A Porcine Model of Traumatic Brain Injury Via Head Rotational Acceleration, Injury Models of Central Nervous System: Traumatic Brain Injury, Methods in Molecular Biology 1462:289-324. Dixon, Kobeissy, Hayes and Mondello eds (2016).

46. Meaney DF and Cullen DK. Biomechanical Basis of Traumatic Brain Injury, Youmans and Winn’s Neurological Surgery, 7th Edition, HR Winn ed. (2016).

45. Petrov D, Katiyar KS (co-first author), Struzyna LA, Harris JP, Cullen DK. Extracellular Matrix-Derived Tissues for Neurological Applications, Extracellular Matrix-Derived Medical Implants in Clinical Medicine, 1st Edition, DL Mooradian ed. (2016).

44. Meng X, Browne KD, Cullen DK, Tofighi MR, Kawoos U, Rosen A. Wireless Intracranial Pressure System for the Assessment of Traumatic Brain Injury. Medical and Biological Microwave Sensors and Systems, I. Mostafanezhad, O. Boric-Lubecke, J. Lin, eds. (2016; in press).

43. Chen HI, Jgamadze D, Serruya MD, Cullen DK, Wolf JA, Smith DH. Neural Substrate Expansion for the Restoration of Brain Function, Frontiers in Systems Neuroscience 10(1) (2016).

42. Harris JP, Struzyna LA, Murphy PL, Adewole DO, Kuo E, Cullen DK. Advanced Biomaterial Strategies to Transplant Preformed Micro-Tissue Engineered Neural Networks into the Brain, J Neural Engineering 13(1):016019 (2016).

41. Johnson VE, Stewart W, Weber MT, Cullen DK, Siman R, Smith DH. SNTF Immunostaining Reveals Previously Undetected Axonal Pathology in Traumatic Brain Injury, Acta Neuropathologica 131(1):115-35 (2016).

40. Struzyna LA, Wolf JA, Mietus CJ, Adewole DO, Chen HI, Smith DH, Cullen DK. Rebuilding Brain Circuitry with Living Micro-Tissue Engineered Neural Networks, Tissue Engin Part A 21(21-22): 2744-56 (2015).

39. Struzyna LA, Harris JP, Katiyar KS, Chen HI, Cullen DK. Restoring Nervous System Structure and Function Using Tissue Engineered Living Scafolds, Neural Regeneration Research 10(5): 679-85 (2015).

38. Ross JD, Cullen DK (co-first author), LaPlaca MC, DeWeerth SP. 3-D Image Processing Techniques for Rapid Automated Segmentation of Neuronal Somata with Dense Neurite Outgrowth, Frontiers in Neuroanatomy, 9 (20 July 2015).

37. Johnson VE, Meaney DF, Cullen DK, Smith DH. Animal Models of Traumatic Brain Injury (Chapter 8), TBI Part 1, Handbook of Clinical Neurology, 27(3): 115-128, J Grafman and AM Salazar, eds. (2015).

36. Struzyna LA, Katiyar KS, Cullen DK. Living Scaffolds for Neuroregeneration, Current Opinion in Solid State & Material Science, 18(6): 308-318 (2014).

35. Harris JP, Browne KD, Wolf JA, Cullen DK. Linking Macro- to Micro-Biomechanics in Closed-Head Traumatic Brain Injury Base on Acute Biophysical Disruptions and Evolving Neurodegeneration, Conf Proc 17th U.S. National Congress on Theoretical and Applied Mechanics (2014).

34. Meng X, Cullen DK, Tofighi MR, Rosen A. Telemetry-Based Neuromonitoring System Measuring Dynamic Intracranial Pressure Following Closed-Head Rotational Injury in Swine, IEEE Life Sciences Newsletter February (2013). LINK

33. Cullen DK and Smith DH. Bionic Connections: Living Bridges to Connect Bionic Limbs to the Nervous System. Scientific American 308(1): 52-57 (2013).

32. Meng X, Browne KD, Huang SM, Mietus CJ, Cullen DK, Tofighi MR Rosen A. Dynamic Evaluation of a Digital Wireless Intracranial Pressure Sensor for the Assessment of Traumatic Brain Injury in a Swine Model, Trans on Microwave Theory and Technology (2012).

31. Cullen DK, Tang-Schomer MD, Struzyna LA, Patel AR, Johnson VE, Wolf JA, Smith DH. Micro-Tissue Engineered Constructs with Living Axons for Targeted Tract Reconstruction, Tissue Engineering Part A 18(21-22)(2012). PMID: 22702955.

30. Meng X, Brown KB, Huang SM, Cullen DK, Tofighi MR, Rosen A. Dynamic Study of Wireless Intracranial Pressure Monitoring of Rotational Head Injury in Swine Model, Electronics Letters 48(7):363-364 (2012).

29. Cullen DK, Browne KD, Xu Y, Adeeb S, Wolf JA, McCarron RM, Yang S, Chavko M, Smith DH. Blast-Induced Color Change in Photonic Crystals Corresponds with Brain Pathology, J Neurotrauma 28:2307-2318 (2011). PMID: 22023510.

28. Cullen DK, Vernekar VN, LaPlaca MC. Trauma-Induced Plasmalemma Disruptions in 3-D Neural Cultures are Dependent on Strain Modality and Rate, J Neurotrauma 28:2219-2233 (2011). PMID: 22023556.

27. Higgins AZ, Cullen DK, LaPlaca MC, Karlsson JOM. Effects of Freezing Profile Parameters on the Survival of Cryopreserved Rat Embryonic Neural Cells, J Neuroscience Methods 201(1):9-16 (2011). PMID: 21816171.

26. Cullen DK and Pfister BJ. Transformative Research in Neural Engineering, Critical Reviews in Biomedical Engineering 39(3):181-183 (2011). PMID: 21967301.

25. Cullen DK, Wolf JA, Smith DH, Pfister BJ. Neural Tissue Engineering for Neuroregeneration and Biohybridized Interface Microsystems In Vivo (Part 2), Critical Reviews in Biomedical Engineering 39(3):241-259 (2011). PMID: 21967304.

24. Cullen DK, Wolf JA, Vernekar VN, Vukasinovic J, LaPlaca MC. Neural Tissue Engineering and Biohybridized Microsystems for Neurobiological Investigation In Vitro (Part 1), Critical Reviews in Biomedical Engineering 39(3):201-240 (2011). PMID: 21967303.

23. Morrison B III, Cullen DK, LaPlaca MC. In Vitro Models for Biomechanical Studies of Neural Tissues. Neural Tissue Mechanics, L. Bilston, ed. (2011).

22. Cullen DK and Pfister BJ. State of the Art and Future Challenges in Neural Engineering: Strategies for Nervous System Repair, Critical Reviews in Biomedical Engineering 39(2):79-80 (2011). PMID: 21488816.

21. Pfister BJ, Gordon T, Loverde JR, Kochar AS, Mackinnon SE, Cullen DK. Biomedical Engineering Strategies for Peripheral Nerve Repair: Surgical Applications, State of the Art, and Future Challenges, Critical Reviews in Biomedical Engineering 39(2):81-124 (2011). PMID: 21488817.

20. Cullen DK and Pfister BJ. State of the Art and Future Challenges in Neural Engineering: Neural Interfaces, Critical Reviews in Biomedical Engineering 39(1):1-3 (2011). PMID 21488811.

19. Cullen DK, Xu Y, Reneer DV, Browne KD, Geddes JW, Yang S, Smith DH. Color Changing Photonic Crystals Detect Blast Exposure, NeuroImage 54S1:S37-S44 (2011). PMID: 21040795. Featured in Science (Editor’s Choice), Technology Review, UPI, Newsworks, Wired, The Engineer.

18. Cullen DK, Gilroy ME, Irons HR, LaPlaca MC. Synapse-to-Neuron Ratio is Inversely Related to Neuronal Density in Mature Neuronal Cultures, Brain Research 1359:44-55 (2010) (cover article). PMID 20800585.

17. LaPlaca MC, Vernekar VN, Shoemaker JT, Cullen DK. Three-Dimensional Neuronal Cultures. Methods in Bioengineering: 3D Tissue Engineering, Berthiaume F and Morgan J, eds. (2010).

16. LaPlaca MC, Prado GR, Cullen DK, Simon CM. Plasma Membrane Damage as a Marker of Neuronal Injury, Conf Proc IEEE Eng Med Biol Soc 2009:1113-6 (2009). PMID: 19964751.

15. Vukasinovic J, Cullen DK, LaPlaca MC, Glezer A. A Microperfused Incubator for Tissue Mimetic 3-D Cultures, Biomedical Microdevices 11(6):1155 (2009). PMID 19562488.

14. Huang JH, Cullen DK (co-first author), Browne KD, Groff R, Zhang J, Pfister BJ, Zager EL, Smith DH. Long-Term Survival and Integration of Transplanted Engineered Nervous Tissue Constructs Promotes Peripheral Nerve Regeneration, Tissue Engineering Part A 15(7):1677-85 (2009). PMID: 19231968.

13. Vernekar VN, Cullen DK, Fogleman N, Choi Y, Garcia AJ, Allen MG, Brewer GJ, LaPlaca MC. SU-8 2000 Rendered Cytocompatible for Neuronal BioMEMS Applications, J Biomed Mater Res A 89(1):138-151 (2009). PMID: 18431778.

12. Cullen DK, Patel AR, Doorish JF, Smith DH, Pfister BJ. Developing a Tissue Engineered Neural-Electrical Relay Using Encapsulated Neuronal Constructs on Conducting Polymer Fibers, J Neural Engineering 5(4):374-384 (2008) (cover article). PMID: 18827311.

11. Kameswaran N, Cullen DK, Pfister BJ, Ranalli NJ, Huang JH, Zager EL, Smith DH. A Novel Neuro-Prosthetic Interface with the Peripheral Nervous System Using Artificially Engineered Axonal Tracts, Neurological Res 30(10):1063-7 (2008). PMID: 19079981.

10. Irons HR, Cullen DK, Shapiro NP, Lambert NA, Lee RH, LaPlaca MC. 3-D Neural Constructs: A Novel Platform for Neurophysiological Investigation, J Neural Engineering 5(3):333-341 (2008). PMID: 18756031.

9. Cullen DK, Stabenfeldt SE, Simon CM, Tate CC, LaPlaca MC. In Vitro Neural Injury Model for Optimization of Tissue Engineered Constructs, J Neurosci Res 85(16):3642-51 (2007). PMID: 17671988.

8. Cullen DK, Simon CM, LaPlaca MC. Strain Rate-Dependent Induction of Reactive Astrogliosis and Cell Death in 3-D Neuronal-Astrocytic Co-Cultures, Brain Res 1158:103-115 (2007) (cover article). PMID: 17555726.

7. LaPlaca MC, Simon CM, Prado GR, Cullen DK. CNS Injury Biomechanics and Experimental Models, Prog Brain Res 161:13-26 (2007). PMID: 17618967.

6. Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC. Microfluidic Engineered High Cell Density 3-D Neural Cultures, J Neural Engineering 4(2):159-172 (2007). PMID: 17409489. Selected as “Highlights of 2007”.

5. Cullen DK, Lessing MC, LaPlaca MC. Collagen-Dependent Neurite Outgrowth and Response to Dynamic Deformation in 3-D Neuronal Cultures, Ann Biomed Engineering 35(5):835-846 (2007). PMID: 17385044.

4. LaPlaca MC, Prado GR, Cullen DK, Irons HR. High Rate Shear Insult Delivered to Cortical Neurons Produces Heterogeneous Membrane Permeability Alterations, Conf Proc IEEE Eng Med Biol Soc 1:2384-7 (2006). PMID: 17946956.

3. Cullen DK and LaPlaca MC. Neuronal Response to High Rate Shear Deformation Depends on Heterogeneity of the Local Strain Field, J Neurotrauma 23(9):1304-1319 (2006). PMID: 16958583.

2. Cullen DK, Vukasinovic J, Glezer A, LaPlaca MC. High Cell Density 3-D Neural Co-Cultures Require Continuous Medium Perfusion for Survival, Conf Proc IEEE Eng Med Biol Soc 1:636-9 (2006). PMID 17946846.

1. LaPlaca MC, Cullen DK, McLoughlin JJ, Cargill RS. High Rate Shear Strain of 3-D Neural Cell Cultures: A New In Vitro Traumatic Brain Injury Model, J Biomech 38(5):1093-1105 (2005). PMID: 15797591.