People
Prinicipal Investigator (PI)
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D. Kacy Cullen
Professor of Neurosurgery & Bioengineering
dkacy@pennmedicine.upenn.edu
Ph.D., Biomedical Engineering, Georgia Institute of Technology (2005)
M.S., Mechanical Engineering, Georgia Institute of Technology (2002)
B.S., Mechanical Engineering, Georgia Institute of Technology (2000)
Faculty
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John C. O'Donnell, Ph.D.
Research Assistant Professor of Neurosurgery
Email John C. O'Donnell, Ph.D.
John C. O'Donnell, Ph.D.
Research Assistant Professor of Neurosurgery
john.charles.odonnell@gmail.com
Projects
Improving Recovery from Moderate-to-Severe Traumatic Brain Injury
Coma and Disorders of Consciousness
Neurocritical Care (e.g., intracranial hypertension)
Tissue Engineered Glial Constructs
Human Tissue Engineered TestbedsAwards & Fellowships
VA RR&D CDA2, Translational Modeling of Brain Injury Rehabilitation to Maximize Recovery (2021-2026)
NIH NRSA F32 Fellowship, Modeling Disorders of Consciousness (2017-2020)Degrees
Ph.D., Neuropharmacology, University of Pennsylvania (2016)
M.S., Biology, Towson University (2009)
B.A., Biology, LaSalle University (2004) -
Suradip Das, Ph.D.
Senior Research Investigator
suradip@pennmedicine.upenn.edu
Projects
Tissue-Engineered Neural Constructs for Neuromuscular Injury RepairDegrees
Ph.D., Biosciences & Bioengineering, Indian Institute of Technology Guawahati (2016)
Lab Management
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Kevin D. Browne, B.A.
Research Project Manager/Lab Manager
kbrowne@pennmedicine.upenn.edu
Projects
Development of a Large Animal Model of Neurointensive Care and Recovery
Plasmalemmal Permeability and Cell Death after Non-Impact Head Trauma and Blast Injury
In Vivo Efficacy Testing of Tissue-Engineered Nerve Grafts for Peripheral Nerve Injury
Micro-Tissue Engineered Neural Networks to Restore Brain Circuitry -
Elizabeth Krizman (Liz)
Center Research Coordinator (Lab Mom)
elizabeth.Krizman@pennmedicine.upenn.edu
Glia Team Lead
Professional Mission Statement
I am committed to helping the next generation of scientists by offering guidance and leveraging my expertise to help advance their careers and research. -
Mike R. Grovola
Research Project Manager
mgrovola@pennmedicine.upenn.edu
Projects
Neuroinflammatory response and the role of microglia after Traumatic Brain Injury
Functional genomics of tissue-engineered neural constructsDegrees
Ph.D. Drexel University, School of Biomedical Engineering
M.S. Drexel University, College of Medicine
B.A. University of Richmond -
Mykhailo Tatarchuk
Research Project Manager
mykhailo.Tatarchuk@pennmedicine.upenn.edu
Projects
Focusing on pioneering the development of next-generation technologies that enable rapid recovery after nerve injury. Nerve Coupler device. Nerve Tape. Tissue Engineered Neural Networks for Spinal Cord Injury Repair.
Degrees
MD. National Medical University, Kyiv, Ukraine (2005)
Ph.D., National Academy of Medical Sciences, Kyiv, Ukraine (2015)
Neurosurgeon, 15 years peripheral nerves surgery work experience
Postdoctoral Fellows
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Dimple Chouhan, Ph.D.
dimple.chouhan@pennmedicine.upenn.edu
Projects
Biofabricatioon of nigrostriatal pathway for the treatment of Parkinson's disease
Tissue-engineered nigrostriatal pathway as test-bed for evaluating axonal pathophysiology in Parkinson's diseaseDegrees
Ph.D., Biosciences & Bioengineering, Indian Institute of Technology Guwahati, India (2019)
B.Tech., Electronics and Communication, Rajasthan Technical University, India (2012) -
Cybelle Smith, Ph.D.
cybelle.smith@pennmedicine.upenn.edu
Projects
Developing an In Vitro Model of Hippocampal Pattern Separation
Computational Design for Functional Neural Tissue Engineering
Exploring Neuron-Astrocyte Functional InteractionsAwards & Fellowships
NSF Graduate Research Fellowship
NIH BRAIN F32Degrees
BA, Linguistics, Stanford University (2011)
MS, Applied Statistics, UIUC (2018)
PhD, Psychology, UIUC (2018) -
Erin M. Purvis, Ph.D.
epurvis@pennmedicine.upenn.edu
Projects
Tissue-Engineered Rostral Migratory Stream for Directed Neuronal ReplacementAwards & Fellowships
Predoctoral Fellowship, National Science Foundation (GRFP)
Provost's Graduate Academic Engagement Fellowship at the Netter Center, University of PennsylvaniaDegrees
B.S., Biopsychology, University of California at Santa Barbara (2017) -
Graduate Students
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Kiera Yankson
Doctoral Student - Bioengineering
kyankson01@gmail.com
ProjectsLiving Deep Brain Stimulation for For External Control of Striatal Dopamine
Awards & Fellowships
Fontaine FellowshipDegrees
B.S., Applied Mathematics (Biology) -
Kyndall Nicholas
Doctoral Student - Neuroscience
kyndall@pennmedicine.upenn.edu
Projects
The Effects of Neuronal Lipid Constituents on Susceptibility to Plasma Membrane Damage in Traumatic Brain InjuryAwards & Fellowships
University of Pennsylvania Graduate Training in Neuroscience Training Grant (NIH- T32)
Howard Hughes Medical Institute Gilliam Fellowship (2023)Degrees
B.S., Biochemistry, Hampton University (2019) -
Melanie Hilman
Doctoral Student - Bioengineering
mhilman@seas.upenn.edu
Projects
Stretch Grown Tissue-Engineered Muscle for Volumetric Muscle Loss RepairDegrees
B.S.E., Bioengineering, University of Pennsylvania (2020)
M.S.E., Mechanical Engineering and Applied Mechanics, University of Pennsylvania (2020) -
Franco Laimo
Doctoral Student
Franco Laimo
Doctoral Student
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Saarang Karandikar
Doctoral Student - Bioengineering
saarangk@sas.upenn.edu
Projects
Upscaling of Micro-Tissue Engineered Neural Networks for Sensorimotor "Living Electrode" ApplicationsDegrees
B.A.S., Neuroscience, University of Pennsylvania (2020) -
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Viviana (vivi) Alpizar Vargas
Doctoral Student - Bioengineering
valpizar@seas.upenn.edu
Project: Genetic modification of Tissue Engineered Nerve Grafts for peripheral nerve regeneration
Awards & Fellowships: Fontaine Fellowship
Education:
B.S., Bioengineering, University of Maryland
B.S., Neuroscience, University of Maryland -
Yihan Xie
Doctoral Student - Bioengineering
Yihan.Xie1@pennmedicine.upenn.edu
Degrees
B.S. Brain and Cognitive Science; B.A. Mathematics University of Rochester (2022) -
Undergraduate Students
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Eric Muthersbaugh
BAS Candidate - Neuroscience (2025)
ericmuth@sas.upenn.edu
Projects
Tissue Engineered Muscular Units and Electrospun Nanofiber Materials -
Srijan Kalva
Neuroscience and Bioengineering (2025)
krpurpura@widener.edu
Education:
Undergraduate Student and Accelerated Master's Student: Neuroscience (Bachelor of Arts) '25 and Bioengineering (Master of Science in Engineering) '25.
Projects:- The Effects of Neuronal Lipid Constituents on Susceptibility to Plasma Membrane Damage in Traumatic Brain Injury (under Kyndall)
- Changes in Dendritic Spines in Traumatic Brain Injury 7 Days Post-Injury Under Different Neuronal Lipid Constituents
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Technicians
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Dan Han
Dan Han
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Lab Affiliates
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Robert B. Shultz, Ph.D.
bob.b.shultz@gmail.com
Projects
Tissue-Engineered Axon Fusion for Immediate Recovery Following Nerve InjuryAwards & Fellowships
NIH NRSA T32 Fellowship (2019-2021); T32 Title: “Training Without Borders: Translating Research in Regenerative Medicine”, lead organization: Rutgers University (PI: Joachim Kohn)Degrees
Ph.D., Biomedical Engineering, Drexel University (2019)
B.S., Biomedical Engineering, Rutgers University (2012) -
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Lab Alumni
Kathryn L. Wofford, Ph.D. (Assistant Professor of Neurosurgery) - https://www.med.upenn.edu/woffordlab/
Projects: Understanding and Employing the Innate Immune System to Promote Regeneration Following Traumatic Brain Injury
Awards & Fellowships: Brain Injury Training Grant “Understanding and Exploiting Innate Immune Cell Infiltration into the Brain Following Trauma” NIH NRSA T32.
Degrees: Ph.D., Biomedical Engineering, Drexel University (2019), M.S., Biomedical Engineering, Drexel University (2015), B.A., Biophysics and Psychology with Honors, Austin College (2012)
Victor Acero:
Project: Engineering an In Vitro Model of Hippocampal Networks
NSF Graduate Research Fellowship, High-Efficiency Kirigami Vase Water Harvester (2018-2021),
Fontaine Fellowship (2017)
Ronit Patel
Project: Tissue-engineered nigrostriatal pathway as test-bed for evaluating axonal pathophysiology in Parkinson's disease
Adedotun Bello
Projects: The Effects of Neuronal Lipid Constituents on Susceptibility to Plasma Membrane Damage in Traumatic Brain Injury, The Impact of Traumatic Brain Injury on White Matter Interstitial Neurons
Andrés Garcia-Epelboim
Sam Lien
Project: Tissue Engineered Nerve Grafts
Olivia Rivellini
Yohannes Ghenbot
Connor Wathen
Project: Tissue Engineered Neural Networks for Spinal Cord Injury Repair
Jerry Gao
Project: Investigating the Colocalization of Damaged Neurons and Perivascular Regions After a Single or Repetitive Diffuse TBI
Shavon Coulter: Undergraduate Student, Xavier University of Louisiana
Annette Prah: Undergraduate Student, Emory University
Natalia Fedorcza: Undergraduate Student, Dickenson University
Wisberty J. Gordián-Vélez: Graduate Student, Bioengineering, University of Pennsylvania
Projects: Transplantable Axonal Tracts as "Living DBS" for Dopamine Replacement in Parkinson's Disease, Three-Dimensional Human Axon Tracts Derived from Cerebral Organoids
Justin C. Burrell: Postdoctoral Fellow, University of Pennsylvania
Projects: Development of Micro-Tissue Engineered Nerve Grafts to Preserve Peripheral Nerve Regeneration Capacity and Maintain the Distal Nerve Pathway, In Vivo Efficacy Testing of Tissue Engineered Nerve Grafts for Peripheral Nerve Injury, Micro-Tissue Engineered Neural Networks to Restore Brain Circuitry
Nicholas Paleologos: Undergraduate Student, Biological Basis of Behavior, University of Pennsylvania
Project: Neuroinflammation and Axonal Pathology Associated with Traumatic Brain Injury in Swine
Kaila Helm: Undergraduate Student, Biological Basis of Behavior, University of Pennsylvania
Project: Tissue-Engineered Living Scaffolds for Neuroregeneration
Carolyn E. Keating: Graduate Student, Neuroscience, University of Pennsylvania
Project: Acute Permeability & Synucleinopathy in TBI and 3D Neural Cell Culture
Dayo Adewole: Graduate Student, Bioengineering, University of Pennsylvania
Project: The Application of Micro-Tissue Engineered Neural Networks as Living Electrodes for Sensorimotor Information
Fellowship: NIH NRSA T32 Fellowship (2018 - 2020), NSF Graduate Research Fellowship, Micro-Tissue Engineered Neural Networks as "Living Electrodes" to Relay Sensory Information for a Brain-Machine Interface (2015-2018)
Vishal Tian: Undergraduate Student, Bioengineering, University of Pennsylvania
Project: Optogenetic Stimulation of Motor Neurons in a Tissue Engineered Nerve Graft to Enhance Axonal Outgrowth
Kritika S. Katiyar, Ph.D.: Bioengineering, Drexel University
Projects: Tissue-Engineered Living Scaffolds for Neuroregeneration; Molecular Mechanisms of Axon-Mediated Axon Regeneration; 3-D Neural Cell Culture Techniques
Fellowship: NIH NRSA F31 Fellowship, Mechanisms for Axonal Guidance Using Living Tissue Engineered Scaffolds (2015-2018)
Halimulati Kaisaier: Undergraduate Student, Bioengineering, University of Pennsylvania
Project: Development of Innervated Tissue Engineered Muscle on Aligned Nanofibers for Volumetric Muscle Loss Repair
Laura A. Struzyna, Ph.D.: Bioengineering, University of Pennsylvania
Projects: Tissue-Engineered Biohybrid Neuroprosthetic Interfaces; Micro-Tissue Engineered Neural Networks to Restore Brain Circuitry; Neurophysiological Assessment of Nervous System Repair
Fellowship: NSF Graduate Research Fellowship, Tissue Engineered Constructs for Neural Repair (2013-2016)
Kate Panzer: Undergraduate Student, Bioengineering, University of Pennsylvania
Project: Tissue-Engineered Living Scaffolds for Neuroregeneration
Joseph Maggiore: Undergraduate Student, Bioengineering, University of Pennsylvania
Project: In Vivo Efficacy Testing of Tissue-Engineered Nerve Grafts for Peripheral Nerve Injury
Dan Brown, B.S.: Research Specialist
Projects: In Vivo Efficacy Testing of Tissue-Engineered Nerve Grafts for Peripheral Nerve Injury; Chronic Neurodegenerative and Neurophysiological Sequela in TBI
Chelsea Wallace, D.V.M.: Staff Veterinarian
Project: Effects of FK506 on Host Regeneration Through Tissue-Engineered Allograft and Xenograft Nerve Constructs
Sanford Roberts, B.A.: Medical Student
Project: Evaluation of Polyethylene Glycol as an Agent of Rapid Axonal Fusion Following Nerve Transection
Dmitriy Petrov, M.D.: Neurosurgical Resident
Project: Micro-Tissue Engineered Neural Networks to Restore Brain Circuitry
Fellowship: Codman Neurotrauma & Critical CareResearch Fellowship, Micro-Tissue Engineered Neural Networks to Restore Hippocampal Circuitry (2015-2016)
Carla Winter: Undergraduate Student, Bioengineering, University of Pennsylvania
Project: Tissue-Engineered Living Scaffolds for Neuroregeneration
Tina Lulla: Undergraduate Student
Project: Micro-Tissue Engineered Neural Networks to Restore Brain Circuitry
Jimmy Harris: Postdoctoral Fellow
Project: Chronic Neurodegenerative and Neurophysiological Sequela in TBI & Micro-Tissue Engineered Neural Networks to Restore Brain Circuitry
Carla Hernandez: Undergraduate Student
Project: Histological Techniques to Assess Neurotrauma Pathology and Repair Strategies
Ryan Zahalka: Undergraduate Student
Project: Molecular Mechanisms of Axon-Mediated Axon Regeneration; Environmental Control for Bench-Top Mechanobioreactor
Ellie Boyle: Undergraduate Student
Project: Tissue Engineering Strategies for Nerve Regeneration
Anthony Parisi: Undergraduate Student
Project: Quantitative Neuropathological Analyses of Rodent and Porcine Tissue Following Traumatic Brain Injury
Joseph Morand, B.S.: Research Specialist
Project: In Vivo Efficacy Testing of Tissue Engineered Nerve Grafts for Peripheral Nerve Injury
Emory Kuo, M.S.: Predoctoral Fellow
Project: Tissue Engineering for Neuroregeneration, Chronic Neurodegenerative and Neurophysiological Sequela in TBI
Constance Mietus, B.A: Research Specialist
Project: Neural Cell Biophysical Responses in Blast-Induced Traumatic Brain Injury
Joe Frasca, Ph.D.: Postdoctoral Fellow
Project: Chronic Neurodegenerative and Neurophysiological Sequela of Closed-Head TBI
John A. Wolf, Ph.D.: Postdoctoral Fellow, University of Pennsylvania
Project: Functional Reorganization of Limbic Circuitry After TBI in Swine, Biohybridized Neural Tissue-Engineered Constructs for Electrical Interface with Peripheral Nerve
Matthew Weingard: Medical Student, Tulane
Project: Tissue Engineering with Primary Cortical Neurons
Scott Yerganian: Bioengineering, University of Pennsylvania
Project: Mechanisms of Axon-Mediated Axon Regeneration
Janid Kiely: Biophysics, University of Pennsylvania
Project: Biomechanics of Concussion: Pathobiological Implications of Acute Cellular Damage
Arshneel Kochar: Medical Student, CWRU
Project: Tissue Engineering Micro-Conduits for Targeted Axonal Tract Reconstruction
Billy Lane: Pre-Med, Notre Dame
Project: Mechanisms of Axonal Degeneration in a Swine Model of Closed-Head TBI
Jonathan Yu: Biology, Haverford College
Project: Tissue Engineering Micro-Conduits for Targeted Axonal Tract Reconstruction