Welcome

The Gandal lab integrates human genetics, functional genomics, computational biology, and developmental neuroscience to identify the biological underpinnings of -- and novel therapeutic targets for -- neurodevelopmental and psychiatric disorders. Our major goals are to translate the ever-expanding results from large-scale genome-wide association and sequencing studies (GWAS/WGS) into tractable biological mechanisms and testable hypotheses. To accomplish this, we are currently working to:

1. Identify the heritable genetic contributions to common neurodevelopmental and neuropsychiatric disorders through population-level genetic and genomic profiling.

2. Elucidate the convergent mechanisms, core pathways, and biomarkers through which genetic variation confers risk/resilience for neuropsychiatric disorders

3. Characterize the brain-level cellular and molecular pathology of heritable neuropsychiatric disorders and connect with genetic risk mechanisms 
4. Translate biological and genetic insights towards the clinic, through personalized risk profiling, disease pathway-level predictions, and novel drug target identification