We are a diverse team leveraging psychiatric genetics, computational biology, functional genomics, and neuroscience to identify the biological underpinnings of -- and novel therapeutic targets for -- neurodevelopmental and psychiatric disorders, including autism (ASD), ADHD, schizophrenia, and bipolar disorder. Our current work focuses on translating the ever-expanding results from large-scale genetic association studies (GWAS) of neuropsychiatric disorders into tractable biological mechanisms and testable hypotheses. To accomplish this, we are currently working to:
Perform population-level genetic and multi-OMIC profiling of the developing and adult human brain
Develop and apply integrative functional genomic methods to identify the target genes and proximal mechanisms within genetic loci associated with psychiatric disorders
Leverage systems biology to identify pathways of convergence among multiple distinct genetic risk factors, at both a population level and within an individual
Characterize the brain-level molecular pathology of major neuropsychiatric disorders, through gene and network-level inference
Pan's paper accepted at PNAS!
"Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex" PDF
Congrats to Arjun Bhattacharya, Oral Presentation Winner at WCPG2022!
Check out his preprint on our isoTWAS method
Congrats to Leanna Hernandez, named SFARI Bridge to Independence Fellow!
She will be starting her independent lab soon at UCLA!