We are a diverse team of scientists integrating genetics, human brain functional genomics, computational biology, and developmental neuroscience to identify the biological underpinnings of -- and novel therapeutic targets for -- neurodevelopmental and psychiatric disorders, including autism (ASD), ADHD, schizophrenia, bipolar disorder, and related traits. Our current work focuses on translating the ever-expanding results from large-scale genome-wide association and sequencing studies (GWAS/WGS) of these disorders into tractable biological mechanisms and testable hypotheses. To accomplish this, we are currently working to:
Identify the heritable genetic contributions to common neurodevelopmental and neuropsychiatric disorders through population-level genetic and genomic profiling
Elucidate the convergent mechanisms, core pathways, and biomarkers through which genetic variation confers risk/resilience for these disorders
- Characterize the brain-level cellular and molecular pathology of heritable neuropsychiatric disorders and connect with genetic risk mechanisms
- Translate biological and genetic insights towards the clinic, through personalized risk profiling, disease pathway-level predictions, and novel drug target identification
Our isoTWAS paper has been published in Nature Genetics!
"Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain."
Welcome to Winter 2024 Rotation Students!
Makaya Reed (Penn GCB) and Shridhar Parthasarathy (Penn MSTP/GCB)
- New Gandal Lab Preprints