Featured Publications

ASD

• 

  Gandal, Haney, Wamsley et al., Nature 2022

   Link
  
  Read More about Gandal, Haney, Wamsley et al., Nature 2022
  

  Gandal, Haney, Wamsley et al., Nature 2022

   Link
  

  Gandal, M. J.*, Haney, J. R., Wamsley, B., Yap, C. X., Parhami, S., Emani, P. S., Chang, N., Chen, G. T., Hoftman, G. D., de Alba, D., Ramaswami, G., Hartl, C. L., Bhattacharya, A., Luo, C., Jin, T., Wang, D., Kawaguchi, R., Quintero, D., Ou, J., … Geschwind, D. H.* (2022). Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD. Nature, 611(7936), 532–539.

  Close modal dialog
• 

  Zhang P et al., PNAS 2023

   PDF
  
  Read More about Zhang P et al., PNAS 2023
  

  Zhang P et al., PNAS 2023

   PDF
  

  Pan Zhang, Alicja Omanska, Bradley P. Ander, Michael J. Gandal*, Boryana Stamovae*, and Cynthia M. Schuman* (2023)  "Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex" PNAS.

  Close modal dialog

Cross-Disorder

• 

  Gandal et al., Science 2018b

   Link
  
  Read More about Gandal et al., Science 2018b
  

  Gandal et al., Science 2018b

   Link
  

  Gandal, M. J.*, Zhang, P., Hadjimichael, E., Walker, R. L., Chen, C., Liu, S., Won, H., van Bakel, H., Varghese, M., Wang, Y., Shieh, A. W., Haney, J., Parhami, S., Belmont, J., Kim, M., Moran Losada, P., Khan, Z., Mleczko, J., Xia, Y., … Geschwind, D. H.* (2018). Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science, 362(6420).

  Close modal dialog
• 

  Hernandez et al., Biol Psych GOS, 2023

   Link
  
  Read More about Hernandez et al., Biol Psych GOS, 2023
  

  Hernandez et al., Biol Psych GOS, 2023

   Link
  

  Hernandez, L. M., Kim, M., Hernandez, C., Thompson, W., Fan, C. C., Galván, A., Dapretto, M., Bookheimer, S. Y., Fuligni, A., & Gandal, M. J. (2023). Decoupling Sleep and Brain Size in Childhood: An Investigation of Genetic Covariation in the Adolescent Brain Cognitive Development Study. Biological Psychiatry Global Open Science, 3(1), 139–148.

  Close modal dialog
• 

  Gandal et al., Science 2018a

   Link
  
  Read More about Gandal et al., Science 2018a
  

  Gandal et al., Science 2018a

   Link
  

  Gandal, M. J., Haney, J. R., Parikshak, N. N., Leppa, V., Ramaswami, G., Hartl, C., Schork, A. J., Appadurai, V., Buil, A., Werge, T. M., Liu, C., White, K. P., CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BROAD Working Group, Horvath, S., & Geschwind, D. H. (2018). Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science, 359(6376), 693–697.

  Close modal dialog

Schizophrenia

• 

  Kim M et al., Nat Neuro, 2021

   Link
  
  Read More about Kim M et al., Nat Neuro, 2021
  

  Kim M et al., Nat Neuro, 2021

   Link
  

  Kim, M., Haney, J. R., Zhang, P., Hernandez, L. M., Wang, L.-K., Perez-Cano, L., Loohuis, L. M. O., de la Torre-Ubieta, L., & Gandal, M. J. (2021). Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia. Nature Neuroscience, 24(6), 799–809.

  Close modal dialog
• 

  Hernandez et al., Genome Biology 2023

   Link
  
  Read More about Hernandez et al., Genome Biology 2023
  

  Hernandez et al., Genome Biology 2023

   Link
  

  Leanna M. Hernandez, Minsoo Kim, Pan Zhang, Richard A. I. Bethlehem, Gil Hoftman, Robert Loughnan, Diana Smith, Susan Y. Bookheimer, Chun Chieh Fan, Carrie E. Bearden, Wesley K. Thompson & Michael J. Gandal.  "Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth." Genome Biology 24, 42 (2023). https://doi.org/10.1186/s13059-023-02878-0

  Close modal dialog

Genetics/Genomics

• 

  Bhattacharya et al., Nature Genetics 2023

   Link
  
  Read More about Bhattacharya et al., Nature Genetics 2023
  

  Bhattacharya et al., Nature Genetics 2023

   Link
  

  Bhattacharya A, Vo DD, Jops C, Kim M, Wen C, Hervoso JL, Pasaniuc B, Gandal MJ. Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain. Nat Genet. 2023 Nov 30. doi: 10.1038/s41588-023-01560-2. PMID: 38036788.

  Github: https://bhattacharya-lab.com/isotwas/n

  Close modal dialog
• 

  Kim et al., Bioinformatics, 2023

   Link
  
  Read More about Kim et al., Bioinformatics, 2023
  

  Kim et al., Bioinformatics, 2023

   Link
  

  Kim, M., Vo, D. D., Kumagai, M. E., Jops, C. T., & Gandal, M. J. (2023). GeneticsMakie.jl: a versatile and scalable toolkit for visualizing locus-level genetic and genomic data. Bioinformatics , 39(1).

  Github: https://github.com/mmkim1210/GeneticsMakie.jl

   

  Close modal dialog

Reviews

• 

  Gandal ES Forum 2023

   Chapter
  
  Read More about Gandal ES Forum 2023
  

  Gandal ES Forum 2023

   Chapter
  

  Michael J. Gandal, 2023. "Contextualizing Convergent Common Variant Mechanisms through Systems Biology"

   

  Exploring and Exploiting Genetic Risk for Psychiatric Disorders
  Edited by: Joshua A. Gordon, Elisabeth Binder

  Citation:
  Exploring and Exploiting Genetic Risk for Psychiatric Disorders
  Edited by: Joshua A. Gordon, Elisabeth Binder
  DOI: 10.7551/mitpress/15380.001.0001
  ISBN (electronic): 9780262377423
  Publisher: The MIT Press
  Published: 2023

  Close modal dialog
• 

  Won et al., ES Forum 2023

   Chapter
  
  Read More about Won et al., ES Forum 2023
  

  Won et al., ES Forum 2023

   Chapter
  

  Hyejung Won, Naomi R. Wray, Elisabeth B. Binder, Kristen J. Brennand, Barbara Franke, Michael J. Gandal, Beth Stevens, Thomas Südhof, Michael J. Ziller, 2023. "Common Alleles: Next Steps in the Study of Common Variants",  Exploring and Exploiting Genetic Risk for Psychiatric Disorders. Edited by: Joshua A. Gordon, Elisabeth Binder

  Citation:
  Exploring and Exploiting Genetic Risk for Psychiatric Disorders
  Edited by: Joshua A. Gordon, Elisabeth Binder
  DOI: 10.7551/mitpress/15380.001.0001
  ISBN (electronic): 9780262377423
  Publisher: The MIT Press
  Published: 2023

  Close modal dialog

All publications

• 

   Google Scholar
  

   Google Scholar
  

  Close modal dialog