Michael J. Gandal, MD, Ph.D.

faculty photo
William & Noreen Hetznecker Associate Professor in Psychiatry
Investigator, Lifespan Brain Institute (LIBI), Penn Med and the Children’s Hospital Philadelphia
Investigator, Autism Spectrum Program of Excellence, University of Pennsylvania
Department: Psychiatry

Contact information
3615 Civic Center Blvd
Abramson Pediatric Research Center, 502B
Philadelphia, PA 19104
Office: 215-573-4438
Education:
BS (Engineering (concentration in Biomedical Computation))
Stanford University, 2006.
Ph.D (Bioengineering)
University of Pennsylvania, 2011.
MD (Medical Scientist Training Program (MSTP), Clinical Neuroscience Training Program )
University of Pennsylvania, 2013.
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Description of Clinical Expertise

adolescents and adults with neurodevelopmental psychiatric disorders

Description of Research Expertise

Research Interests: We integrate computational biology and functional genomics in the human brain to understand the genetic mechanisms contributing to -- and novel therapeutic targets for -- neurodevelopmental and psychiatric disorders.

Keywords: Psychiatric genetics, functional genomics, transcriptomics, human brain development, gene network biology, neurodevelopmental disorders, genome-wide association studies (GWAS), whole genome sequencing, Autism Spectrum Disorder (ASD), ADHD, bipolar disorder, and schizophrenia.


Research Details, Rotation Projects, Lab Personnel
See: www.gandallab.org

Selected Publications

Sha Z, Sun KY, Jung B, Barzilay R, Moore TM, Almasy L, Forsyth JK, Prem S, Gandal MJ, Seidlitz J, Glessner JT, Alexander-Bloch AF.: The copy number variant architecture of psychopathology and cognitive development in the ABCD (®) study. medRxiv May 2024.

Patowary A, Zhang P, Jops C, Vuong CK, Ge X, Hou K, Kim M, Gong N, Margolis M, Vo D, Wang X, Liu C, Pasaniuc B, Li JJ, Gandal MJ, de la Torre-Ubieta L.: Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms. Science 384: eadh7688, May 2024.

Xia Y, Xia C, Jiang Y, Chen Y, Zhou J, Dai R, Han C, Mao Z; PsychENCODE Consortium; Liu C, Chen C.: Transcriptomic sex differences in postmortem brain samples from patients with psychiatric disorders. Sci Transl Med 16: eadh9974, May 2024.

Yap CX, Vo DD, Heffel MG, Bhattacharya A, Wen C, Yang Y, Kemper KE, Zeng J, Zheng Z, Zhu Z, Hannon E, Vellame DS, Franklin A, Caggiano C, Wamsley B, Geschwind DH, Zaitlen N, Gusev A, Pasaniuc B, Mill J, Luo C, Gandal MJ.: Brain cell-type shifts in Alzheimer's disease, autism, and schizophrenia interrogated using methylomics and genetics. Sci Adv 10: eadn7655, May 2024.

Pratt HE, Andrews G, Shedd N, Phalke N, Li T, Pampari A, Jensen M, Wen C, Consortium P, Gandal MJ, Geschwind DH, Gerstein M, Moore J, Kundaje A, Colubri A, Weng Z.: Using a comprehensive atlas and predictive models to reveal the complexity and evolution of brain-active regulatory elements. Sci Adv 10: eadj4452, May 2024.

Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Tang M, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H; PsychENCODE Consortium†; Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ; PsychENCODE Consortium.: Cross-ancestry atlas of gene, isoform, and splicing regulation in the developing human brain. Science 384: eadh0829, May 2024.

Emani PS, Liu JJ, Clarke D, Jensen M, Warrell J, Gupta C, Meng R, Lee CY, Xu S, Dursun C, Lou S, Chen Y, Chu Z, Galeev T, Hwang A, Li Y, Ni P, Zhou X; PsychENCODE Consortium‡; Bakken TE, Bendl J, Bicks L, Chatterjee T, Cheng L, Cheng Y, Dai Y, Duan Z, Flaherty M, Fullard JF, Gancz M, Garrido-Martín D, Gaynor-Gillett S, Grundman J, Hawken N, Henry E, Hoffman GE, Huang A, Jiang Y, Jin T, Jorstad NL, Kawaguchi R, Khullar S, Liu J, Liu J, Liu S, Ma S, Margolis M, Mazariegos S, Moore J, Moran JR, Nguyen E, Phalke N, Pjanic M, Pratt H, Quintero D, Rajagopalan AS, Riesenmy TR, Shedd N, Shi M, Spector M, Terwilliger R, Travaglini KJ, Wamsley B, Wang G, Xia Y, Xiao S, Yang AC, Zheng S, Gandal MJ, Lee D, Lein ES, Roussos P, Sestan N, Weng Z, White KP, Won H, Girgenti MJ, Zhang J, Wang D, Geschwind D, Gerstein M; PsychENCODE Consortium.: Single-cell genomics and regulatory networks for 388 human brains. Science 384: eadi5199, May 2024.

Huuki-Myers LA, Spangler A, Eagles NJ, Montgomery KD, Kwon SH, Guo B, Grant-Peters M, Divecha HR, Tippani M, Sriworarat C, Nguyen AB, Ravichandran P, Tran MN, Seyedian A; PsychENCODE Consortium†; Hyde TM, Kleinman JE, Battle A, Page SC, Ryten M, Hicks SC, Martinowich K, Collado-Torres L, Maynard KR; PsychENCODE Consortium.: A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex. Science 384: eadh1938, May 2024.

Ruzicka WB, Mohammadi S, Fullard JF, Davila-Velderrain J, Subburaju S, Tso DR, Hourihan M, Jiang S, Lee HC, Bendl J; PsychENCODE Consortium§; Voloudakis G, Haroutunian V, Hoffman GE, Roussos P, Kellis M; PsychENCODE Consortium.: Single-cell multi-cohort dissection of the schizophrenia transcriptome. Science 384: eadg5136, May 2024.

Deng C, Whalen S, Steyert M, Ziffra R, Przytycki PF, Inoue F, Pereira DA, Capauto D, Norton S, Vaccarino FM; PsychENCODE Consortium‡; Pollen AA, Nowakowski TJ, Ahituv N, Pollard KS; PsychENCODE Consortium.: Massively parallel characterization of regulatory elements in the developing human cortex. Science 384: eadh0559, May 2024.

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Last updated: 06/28/2024
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