Michael J. Gandal, MD, Ph.D.
William & Noreen Hetznecker Associate Professor in Psychiatry
Investigator, Lifespan Brain Institute (LIBI), Penn Med and the Children’s Hospital Philadelphia
Investigator, Autism Spectrum Program of Excellence, University of Pennsylvania
Department: Psychiatry
Graduate Group Affiliations
Contact information
3615 Civic Center Blvd
Abramson Pediatric Research Center, 502B
Philadelphia, PA 19104
Abramson Pediatric Research Center, 502B
Philadelphia, PA 19104
Office: 215-573-4438
Publications
Education:
BS (Engineering (concentration in Biomedical Computation))
Stanford University, 2006.
Ph.D (Bioengineering)
University of Pennsylvania, 2011.
MD (Medical Scientist Training Program (MSTP), Clinical Neuroscience Training Program )
University of Pennsylvania, 2013.
Permanent linkBS (Engineering (concentration in Biomedical Computation))
Stanford University, 2006.
Ph.D (Bioengineering)
University of Pennsylvania, 2011.
MD (Medical Scientist Training Program (MSTP), Clinical Neuroscience Training Program )
University of Pennsylvania, 2013.
Description of Clinical Expertise
adolescents and adults with neurodevelopmental psychiatric disordersDescription of Research Expertise
Research Interests: We integrate computational biology and functional genomics in the human brain to understand the genetic mechanisms contributing to -- and novel therapeutic targets for -- neurodevelopmental and psychiatric disorders.Keywords: Psychiatric genetics, functional genomics, transcriptomics, human brain development, gene network biology, neurodevelopmental disorders, genome-wide association studies (GWAS), whole genome sequencing, Autism Spectrum Disorder (ASD), ADHD, bipolar disorder, and schizophrenia.
Research Details, Rotation Projects, Lab Personnel
See: www.gandallab.org
Selected Publications
Patowary A, Zhang P, Jops C, Vuong CK, Ge X, Hou K, Kim M, Gong N, Margolis M, Vo D, Wang X, Liu C, Pasaniuc B, Li JJ, Gandal MJ, de la Torre-Ubieta L.: Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms. bioRxiv Oct 2023.Kourdougli N, Suresh A, Liu B, Juarez P, Lin A, Chung DT, Graven Sams A, Gandal MJ, Martínez-Cerdeño V, Buonomano DV, Hall BJ, Mombereau C, Portera-Cailliau C.: Improvement of sensory deficits in fragile X mice by increasing cortical interneuron activity after the critical period. Neuron 111: 2863-2880, Sep 2023.
Wu Y, Goleva SB, Breidenbach LB, Kim M, MacGregor S, Gandal MJ, Davis LK, Wray NR.: 150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility. Cell Genom 3: 100326, Jun 2023.
Min S, Gandal MJ, Kopp RF, Liu C, Chen C.: No Increased Detection of Nucleic Acids of CNS-related Viruses in the Brains of Patients with Schizophrenia, Bipolar Disorder, and Autism Spectrum Disorder. Schizophr Bull 49: 551-558, May 2023.
Wen C, Margolis M, Dai R, Zhang P, Przytycki PF, Vo DD, Bhattacharya A, Matoba N, Jiao C, Kim M, Tsai E, Hoh C, Aygün N, Walker RL, Chatzinakos C, Clarke D, Pratt H, Consortium P, Peters MA, Gerstein M, Daskalakis NP, Weng Z, Jaffe AE, Kleinman JE, Hyde TM, Weinberger DR, Bray NJ, Sestan N, Geschwind DH, Roeder K, Gusev A, Pasaniuc B, Stein JL, Love MI, Pollard KS, Liu C, Gandal MJ.: Cross-ancestry, cell-type-informed atlas of gene, isoform, and splicing regulation in the developing human brain. medRxiv Mar 2023.
Zhang P, Omanska A, Ander BP, Gandal MJ, Stamova B, Schumann CM.: Neuron-specific transcriptomic signatures indicate neuroinflammation and altered neuronal activity in ASD temporal cortex. Proc Natl Acad Sci U S A 120: e2206758120, Mar 2023.
Hernandez LM, Kim M, Zhang P, Bethlehem RAI, Hoftman G, Loughnan R, Smith D, Bookheimer SY, Fan CC, Bearden CE, Thompson WK, Gandal MJ.: Multi-ancestry phenome-wide association of complement component 4 variation with psychiatric and brain phenotypes in youth. Genome Biol 24: 42, Mar 2023.
Kim M, Vo DD, Kumagai ME, Jops CT, Gandal MJ.: GeneticsMakie.jl: a versatile and scalable toolkit for visualizing locus-level genetic and genomic data. Bioinformatics 39: btac786, Jan 2023.
Kim M, Vo DD, Jops CT, Wen C, Patowary A, Bhattacharya A, Yap CX, Zhou H, Gandal MJ: Multivariate variance components analysis uncovers genetic architecture of brain isoform expression and novel psychiatric disease mechanisms. medrxiv 2023.
Gandal MJ: Contextualizing Convergent Common Variant Mechanisms through Systems Biology. Exploring and Exploiting Genetic Risk for Psychiatric Disorders. Joshua A Gordon, Elisabeth Binder (eds.). The MIT Press, 2023.