TC 210 Eligibility Criteria

Inclusion Criteria

  1. Patient is > 18 years of age at the time the Informed Consent is signed.
  2. Patient has a pathologically confirmed diagnosis of either Malignant Pleural/Peritoneal Mesothelioma (MPM), Serous Ovarian Adenocarcinoma, Cholangiocarcinoma, or Non-Small Cell Lung Cancer (NSCLC).
  3. Patient's tumor has been pathologically reviewed by the central laboratory with confirmed positive MSLN expression on > 50% of tumor cells that are 2+ and/or 3+ by immunohistochemistry.
  4. Prior to gavo-cel infusion, patients must have received at least 1 systemic standard of care therapy for metastatic or unresectable disease with more details provided in the clinical protocol
  5. Patient has an Eastern Cooperative Oncology Group performance status 0 or 1.
  6. Patient has a left ventricular ejection fraction > 45% as measured by resting echocardiogram, with no clinically significant pericardial effusion.
  7. Patient is fit for leukapheresis and has adequate venous access for the cell collection.
  8. Patient must have adequate organ function as indicated by the laboratory values in the clinical protocol