About the High-throughput Screening Core

The High-throughput Screening Core (HTSC) in the Perelman School of Medicine provides expertise and infrastructure to facilitate the development and implementation of professional High-throughput screening services. We have the capabilities to perform HTS in both biochemical and cell-based assays using state-of-the-art equipment. We can perform genetic or small molecule screens to identify genes or small molecule modulators of diverse processes in diverse models including primary cells.  The HTSC educates and assists scientists with HTS assay development, optimization, miniaturization, implementation, analysis, and validation. We can develop new assays or run validated HTS assays. In addition, the HTSC maintains libraries of siRNA, shRNA, cDNA, and FDA-approved/FDA-like organic small molecule libraries for HTS.  Moreover, we routinely prepare custom libraries for single-point or dose-response screening. The HTSC provides robotics infrastructure and technically trained staff for primary HTSs as well as secondary screens to validate candidates. The HTSC also provides assistance with the preparation of grant applications and Letters of Support, offering HTS resources and analysis expertise for the proposed research.

We're Hiring!

The High-throughput Screening Core (HTSC) is searching for a Research Specialist with deep expertise in recombinant protein expression, purification, and biochemistry.   services.  The ideal candidate will independently design strategies for recombinant protein expression and purification using bacterial, insect, and/or mammalian systems; and have the ability to develop, optimize, and troubleshoot purification protocols using standard chromatographic methods (e.g., affinity, ion exchange, size exclusion) to achieve specific project needs.  In addition, the candidate must have excellent organizational and communication skills, and the ability to work within a team.  Interested candidates can contact David Schultz at  dschultz@pennmedicine.upenn.edu or apply at https://wd1.myworkdaysite.com/recruiting/upenn/careers-at-penn/job/Medical-School-John-Morgan-Bldg/Research-Specialist-C_JR00114213-1.