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Jason D. Christie, MD/MSCE

Paul F. Harron, Jr. Family Professor

  • Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
  • Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
  • Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
  • Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
  • Executive Committee, Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania

Department: Medicine
Division: Pulmonary, Allergy and Critical Care


Graduate Group Affiliations


Contact Information

Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Email: jchristi@upenn.edu


I3H Keywords

  • Transplantation Immunity

Publications

Pubmed Link


Links


Education

  • Sc.B. (Chemistry)
    Brown University, 1989
  • M.D. (Medicine)
    Columbia University, 1993
  • M.S.C.E. (Clinical Epidemiology)
    University of Pennsylvania, 2002

Post-Graduate Training

  • Resident in Medicine
    Hospital of the University of Pennsylvania, 1993 - 1996
  • Chief Medical Resident
    Hospital of the University of Pennsylvania, 1996 - 1997
  • Fellow, Division of Pulmonary and Critical Care Medicine
    Hospital of the University of Pennsylvania , 1997 - 2000
  • Fellow, Center for Clinical Epidemiology and Biostatistics
    University of Pennsylvania, 1998 - 2000

Certifications

  • Internal Medicine, 1996
  • Pulmonary Medicine, 2000
  • Critical Care Medicine, 2001
  • Epidemiology, 2003
  • Critical Care Medicine, 2010
  • Internal Medicine, 2006
  • Pulmonary Disease, 2009

Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Description of ITMAT Expertise

His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. Through leadership of the Center for Translational Lung Biology, Dr. Christie brings together clinicians, bench scientists, epidemiologists, and statisticians to build multidisciplinary research teams. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens.

Selected Publications

  • Geng Z, Hynes AM, Moren AM, Christie JD, Mangalmurti NS, Li P, Gallagher JJ, Abella BS, Nam JJ, Schmulevich D, Nathens AB, Reilly PM, Zonies DH, Kaplan LJ, Cannon JW. : Acute Respiratory Distress Syndrome in Trauma 2007-2019: Comprehensive Patient and Center-Level Retrospective Cohort Analysis Crit Care Med Nov 2025
  • Gleeson PK, Morales KH, Lee HJ, Fadugba OO, Patel PJ, Banerjee A, Apter AJ, Christie JD, Kerlin MP. : Guideline adherence to aeroallergen-focused activities in adult asthma care: Insights from an online survey J Allergy Clin Immunol Oct 2025
  • Whiteside SA, McGinniss JE, Deek RA, Merenstein C, Britton N, Simon-Soro A, Oyster M, Kalman L, Brown MC, Graham-Wooten J, McDyer JF, Shah P, D'Alessio F, Cantu E, Clausen ES, Li H, Diamond JM, Bushman FD, Christie JD, Collman RG. : Lung transplant for CF: Low lung bacterial burden and immune mediators in year one associate with clad development J Cyst Fibros Oct 2025
  • Gómez LF, Lactaoen KD, Gleeson PK, Schreibman A, Christie JD, Apter AJ, Hubbard RA, Weissman GE, Himes BE. : Impact of the COVID-19 Pandemic on Adult Asthma-Related Healthcare Utilization medRxiv Sep 2025
  • Yehya N, Till JE, Srivastava N, Zhang D, Christie JD, Carpenter EL, Mangalmurti NS, Zhou W. : Cell-free DNA methylomics identify tissue injury patterns in pediatric ARDS JCI Insight 10 : e191684, Sep 2025
  • Bennett RM, Housel KC, Jones TK, Giannini HM, Emre G, Esperanza M, Turner A, Ittner C, Shashaty MGS, Feng R, Anderson MR, Weissman GE, Meyer NJ, Christie JD, Reilly JP. : Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange Crit Care Explor 7 : e1314, Sep 2025
  • Patrick W Mellors , Ana N Lange , Bruno Casino Remondo , Maksim Shestov , Joseph D Planer , Andrew R Peterson, Yun Ying , Su Zhou , Jason D Christie , Joshua M Diamond , Edward Cantu , Maria C Basil , Saar Gill : Shared roles of immune and stromal cells in the pathogenesis of human bronchiolitis obliterans syndrome JCI Insite April 2025
  • Claire E Fishman 1, Ciara Walshe 2, Tamara Claridge 2, Stephanie Witek 2, Krishna Pandya 3, Jason D Christie 3, Joshua M Diamond 3, Michaela R Anderson 4 : Tolerability and Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists in Lung Transplant Recipients: A Single Center Report Transplantation Proceedings : 342-347, March 2025
  • Brittany Koons, James D Mendez, Michaela R Anderson, Edward Cantu, Matthew Hartwig, Christian Merlo, Krishna Pandya, Emily Vail, Jonathan P Singer, Jason D Christie : Clinical and System-Level Factors Driving Donor Lung Utilization Decisions: A Qualitative Study Annals of the American Thoracic Society March 2025 Notes: Online ahead of print.
  • Felicia Y Ho, Xingmei Wang, Douglas E Schaubel, Mauer Biscotti 3rd, Marisa Cevasco, Aditya G Parikh, Meeta P Kerlin, Jason D Christie, Peter P Reese, Emily A Vail : Heart donation and transplant recipient survival outcomes from deceased organ donors managed in hospital-based vs independent donor care units The Journal of Heart and Lung Transplantation March 2025 Notes: Online ahead of print.