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Jason D. Christie, MD/MSCE

Paul F. Harron, Jr. Family Professor

  • Member, Biomedical Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Department of Biostatistics and Epidemiology
  • Senior Scholar, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania
  • Adjunct Investigator, Institute for Environmental Medicine, Perelman School of Medicine at the University of Pennsylvania
  • Chief, Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania
  • Executive Committee, Penn Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania

Department: Medicine
Division: Pulmonary, Allergy and Critical Care


Graduate Group Affiliations


Contact Information

Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Email: jason.christie@pennmedicine.upenn.edu


I3H Keywords

  • Transplantation Immunity

Publications

Pubmed Link


Links


Education

  • Sc.B. (Chemistry)
    Brown University, 1989
  • M.D. (Medicine)
    Columbia University, 1993
  • M.S.C.E. (Clinical Epidemiology)
    University of Pennsylvania, 2002

Post-Graduate Training

  • Resident in Medicine
    Hospital of the University of Pennsylvania, 1993 - 1996
  • Chief Medical Resident
    Hospital of the University of Pennsylvania, 1996 - 1997
  • Fellow, Division of Pulmonary and Critical Care Medicine
    Hospital of the University of Pennsylvania , 1997 - 2000
  • Fellow, Center for Clinical Epidemiology and Biostatistics
    University of Pennsylvania, 1998 - 2000

Certifications

  • Internal Medicine, 1996
  • Pulmonary Medicine, 2000
  • Critical Care Medicine, 2001
  • Epidemiology, 2003
  • Critical Care Medicine, 2010
  • Internal Medicine, 2006
  • Pulmonary Disease, 2009

Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Description of ITMAT Expertise

His career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. Through leadership of the Center for Translational Lung Biology, Dr. Christie brings together clinicians, bench scientists, epidemiologists, and statisticians to build multidisciplinary research teams. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens.

Selected Publications

  • Patrick K Gleeson, Knashawn H Morales, Meeta Prasad Kerlin, Olajumoke O Fadugba, Andrea J Apter, Jason D Christie, Blanca E Himes : Racial differences in odds of asthma exacerbations among Aspergillus fumigatus-sensitized adults with asthma Annals Of Allergy, Asthma & Immunology : 1206(24)01504-7, September 2024 Notes: Online ahead of print.
  • Adora N Moneme, Mallory Hunt, Jacqueline Friskey, Madeline McCurry, Dun Jin, Joshua M Diamond, Michaela R Anderson, Emily S Clausen, Aya Saleh, Allie Raevsky, Jason D Christie, Douglas Schaubel, Jesse Hsu, A Russell Localio, Robert Gallop, Edward Cantu : Evaluating US Multiple Listing Practices in Lung Transplantation: Unveiling Hidden Disparities Chest August 2024 Notes: Online ahead of print.
  • Tatsuki Koyama, Zhiguo Zhao, John R Balmes, Carolyn S Calfee, Michael A Matthay, John P Reilly, Mary K Porteous, Joshua M Diamond, Jason D Christie, Edward Cantu, Lorraine B Ware; Lung Transplant Outcomes Group : Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation J Heart Lung Transplant 24 : 1053-2498, July 2024 Notes: Online ahead of print.
  • Emily A Vail, Vicky W Tam, Elizabeth M Sonnenberg, Nikhil R Lavu, Peter P Reese, Peter L Abt, Niels D Martin, Richard D Hasz, Kim M Olthoff, Meeta P Kerlin, Jason D Christie, Mark D Neuman, Vishnu S Potluri : Characterizing proximity and transfers of deceased organ donors to donor care units in the United States Am J Transplant 6 : 983-992, June 2024 Notes: available on 2025-06-01
  • Emily A Vail, Xingmei Wang, Douglas E Schaubel, Peter P Reese, Edward Cantu, Niels D Martin, Peter L Abt, Kim M Olthoff, Meeta P Kerlin, Jason D Christie, Mark D Neuman : Lung Donation and Transplant Recipient Outcomes at Independent vs Hospital-Based Donor Care Units JAMA Netw Open June 2024
  • Edward Cantu, Joshua Diamond, Nikhil Ganjoo, Ana Nottigham, Christian Vivar Ramon, Madeline McCurry, Jacqueline Friskey, Dun Jin, Michaela R Anderson, Jessica Lisowski, Audrey Le Mahajan, A Russell Localio, Robert Gallop, Jesse Hsu, Jason Christie, Douglas E Schaubel : Scoring donor lungs for graft failure risk: The Lung Donor Risk Index (LDRI) Am J Transplant 5 : 839-849, May 2024 Notes: Epub 2024 Jan 22.
  • Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. : Vascular Endothelial-derived SPARCL1 Exacerbates Viral Pneumonia Through Pro-Inflammatory Macrophage Activation bioRxiv May 2024
  • Nadir Yehya, Thomas J Booth, Gnana D Ardhanari, Jill M Thompson, L K Metthew Lam, Jacob E Till, Mark V Mai, Garrett Keim, Daniel J McKeone, E Scott Halstead, Patrick Lahni, Brian M Varisco, Wanding Zhou, Erica L Carpenter, Jason D Christie, Nilam S Mangalmurti : Inflammatory and tissue injury marker dynamics in pediatric acute respiratory distress syndrome The Journal of Clinical Investigation 10 April 2024
  • Joshua M Diamond, Michaela R Anderson, Edward Cantu, Emily S Clausen, Michael G S Shashaty, Laurel Kalman, Michelle Oyster, Maria M Crespo, Christian A Bermudez, Luke Benvenuto, Scott M Palmer, Laurie D Snyder, Matthew G Hartwig, Keith Wille, Chadi Hage, John F McDyer, Christian A Merlo, Pali D Shah, Jonathan B Orens, Ghundeep S Dhillon, Vibha N Lama, Mrunal G Patel, Jonathan P Singer, Ramsey R Hachem, Andrew P Michelson, Jesse Hsu, A Russell Localio, Jason D Christie : Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates J Heart Lung Transplant 4 : 633-641, April 2024 Notes: (available on 2025-04-01)
  • Diamond JM, Benvenuto L, Claridge T, Witek S, Christie JD, Singer JP, Anderson MR. : Provider beliefs and practices regarding the management of obesity in lung transplant recipients JHLT Open February 2024