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Jonni S. Moore, PhD

Professor of Pathology and Laboratory Medicine at the Hospital of the University of Pennsylvania

  • Faculty Director, Penn Cytomics and Cell Sorting Shared Resource, University of Pennsylvania School of Medicine
  • Executive Director, Path BioResource, Department of Pathology and Laboratory Medicine, Perleman School of Medicine
  • member, Institute for Immunology, Perleman School of Medicine
  • Diversity Search Advisor, Department of Pathology and Laboratory Medicine, Perelman School of Medicine
  • Senior Advisor, Clinical Flow Cytometry, Hospital of University of Pennsylvania
  • member, Abrasion Cancer Center of the University of Pennsylvania
  • member, Parker Center for Cancer Immunotherapy
  • PSOM Lead Diversity Search Advisor, Perelman School of Medicine, University of Pennsylvania
  • member, Immune Health Council, Perelman School of Medicine, University of Pennsylvania

Department: Pathology and Laboratory Medicine


Graduate Group Affiliations


Contact Information

211 and 297 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104
Office: (215) 898-6853
Fax: (215) 898-4227
Email: moorej@pennmedicine.upenn.edu


I3H Keywords

  • Cancer Immunology and Immunotherapy
  • Precision Immunology and Measuring Immune Health

Publications

Pubmed Link


Links


Education

  • B.A. (Biology)
    University of Virginia, Charlottesville, 1972
  • Ph.D. (Microbiology)
    Thomas Jefferson University, Philadelphia, 1984

Post-Graduate Training

  • Postdoctoral Fellow, Immunology Graduate Group, Dr. Peter C. Nowell and Dr. Richard G. Hoover
    University of Pennsylvania School of Medicine, 1984 - 1988

Certifications

  • Becton-Dickinson FACScan Key Operator, 1990
  • Becton-Dickinson FACStar PLUS Key Operator, 1992

Description of Research Expertise

Research Summary

Research in our laboratory centers on technology development with a focus on complex technologies, in particular cytomics. We pioneered new technology in flow cytometry liquid biopsies including the detection of extracellular vesicles as a rich source of prognostic and diagnostic information and developing this technology for diagnostics/prognostics in cardiovascular disease, traumatic brian injury and relapsing breast cancer. Most recently we have focused on the development of high dimensional deep phenotyping approaches for the identification of biomarkers of cancer responses using advance cytomic technology.
Current collaborators:
Lewis Chodosh, MD, PhD, Cancer Biology
Erica Carpenter, MBA, PhD, Department of Medicine
John Wherry, PhD, Department of Microbiology, Parker Institute for Cancer Immunotherapy

Selected Publications

  • Apostolia M. Tsimberidou, Farah A. Alayli, Kwame Okrah, Alexandra Drakaki, Danny N. Khalil, Shivaani Kummar, Saad A. Khan, F. Stephen Hodi, David Y. Oh, Christopher R. Cabanski, Shikha Gautam, Stefanie L. Meier, Meelad Amouzgar, Shannon M. Pfeiffer, Robin Kageyama, EnJun Yang, Marko Spasic, Michael T. Tetzlaff, Wai Chin Foo, Travis J. Hollmann, Yanyun Li, Matthew Adamow, Phillip Wong, Jonni S. Moore, Sharlene Velichko, Richard O. Chen, Dinesh Kumar, Samantha Bucktrout, Ramy Ibrahim, Ute Dugan, Lisa Salvador, Vanessa M. Hubbard-Lucey, Jill O’Donnell-Tormey, Sandra Santulli-Marotto, Lisa H. Butterfield, Diane M. Da Silva, Justin Fairchild, Theresa M. LaVallee, Lacey J. Padrón, Padmanee Sharma : Immunologic signatures of response and resistance to nivolumab with ipilimumab in advanced metastatic cancer. . J Exp Med 221 : 221 (10), August 2024 Notes: ): e20240152. doi: https://doi.org/10.1084/jem.20240152
  • Bellomo TR, Tsao NL, Johnston-Cox H, Borkowski K, Shakt G, Judy R, Moore J, Ractcliffe SJ, Fiehn O, Floyd TF, Wehrli FW, Mohler E, Newman JW, Damrauer SM. : Metabolite patterns associated with individual response to supervised exercise therapy in patients with intermittent claudication JVS Vasc Sci. 3 : 379-388, October 2022 Notes: doi: 10.1016/j.jvssci.2022.10.002.
  • Moen Sen, 1 Ryan M. Hausler, 1 Keely Dulmage, 2 Taylor A. Black, 1 William Murphy, 3 Charles H. Pletcher Jr, 3Ling Wang, 2 Chang Chen, 2 Stephanie S. Yee, 1 Scott J. Bornheimer, 4 Kara N. Maxwell, 1 Ben Z. Stanger, 5Jonni S. Moore, 3 Jeffrey C. Thompson, 6 and Erica L. Carpenter 1 : Transcriptional profiling of single tumor cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra-cellular matrix marker expression Clin Trans Med 12(7) July (online) 2022
  • Padrón LJ, Maurer DM, O'Hara MH, O'Reilly EM, Wolff RA, Wainberg ZA, Ko AH, Fisher G, Rahma O, Lyman JP, Cabanski CR, Yu JX, Pfeiffer SM, Spasic M, Xu J, Gherardini PF, Karakunnel J, Mick R, Alanio C, Byrne KT, Hollmann TJ, Moore JS, Jones DD, Tognetti M, Chen RO, Yang X, Salvador L, Wherry EJ, Dugan U, O'Donnell-Tormey J, Butterfield LH, Hubbard-Lucey VM, Ibrahim R, Fairchild J, Bucktrout S, LaVallee TM, Vonderheide RH. : Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial Nat.Med 28 : 1167, 2022 Notes: doi: 10.1038/s41591-022-01829-9 Epub ahead of print
  • Matthew Galsky, Karen Autio, Kristopher Wentzel, Julie Graff, Terence Friedlander, Julie Densmore,Christopher Cabanski, Kristin Shotts, Tim Howes, Jia Yu,Elaine Eisenbeisz, Marko Spasic,Stephen Maddock6 Diane DaSilva,Dinesh Kumar, Jonni Moore, Richard Schretzenmair, Jennifer Lata, Arron Xu, Emma Reuschel, Snehal Wani, Matthew Morrow, Jeffrey Skolnik, Sandra Santulli-Marotto, Lacey Padron, Lisa Butterfield, Theresa LaVallee, Samantha Bucktrout, Michael Yellin, Tibor Keler9 Lisa Salvador, Jill O'Donnell-Tourmey, Vanessa Lucey, Justin Fairchild, Ute Dugan, Nina Bhardwaj, Sumit Subudhi, Lawrence Fong : 555 Clinical and pharmacodynamic biomarker results from PORTER, a multi-cohort phase 1 platform trial of combination immunotherapy for metastatic castration-resistant cancer patients Journal for ImmunoTherapy of Cancer 10 2022
  • Habertheuer, Andreas; Ram, Chirag; Schmierer, Maggie; Chatterjee, Shampa; Hu, Robert; Freas, Andrew; Zielinski, Patrick; Rogers, Wade; Silvestro, Eva M; McGrane, Michael; Moore, Jonni S; Korutla, Laxminarayana; Siddiqui, Sarmad; Xin, Yi; Rizi, Rahim; Qin Tao, Jian; Kreisel, Daniel; Naji, Ali; Ochiya, Takahiro; Vallabhajosyula, Prashanth : Circulating Donor Lung-specific Exosome Profiles Enable Noninvasive Monitoring of Acute Rejection in a Rodent Orthotopic Lung Transplantation Model. Transplantation 106 (4) : 754-766, 2022
  • Moore, J : Howard M. Shapiro: Remembering Cytometry's Muse Cytometry Part A 99(12) : 1169, December 2021 Notes: doi: 10.1002/cyto.a.24515.
  • Jones,D, Schretzenmair, RD, Jakobowski, J, Brake-Silla, N, Peterson, T, Steichen, A, Wu, A, Balderas, R, Moore, J. : Development of a 35-color high parameter immune monitoring panel using a novel spectral cytometer. CytoVirtual Interactive 2021 June 2021 Notes: Video poster at virtual conferences
  • Ionita, M, Rogers, W, Schretzenmair, R, Jones, D, Greenplate, A, Moore, J, Wang, L-S. : HitMapper: High throughput mapper for relational analysis of cell states. CytoVirtual Interactive 2021 June 2021 Notes: Presented as a video poster at virtual conference
  • Morchauser, A, Yang, Z, Murphy, W, Tian, S, Issadore, D, Moore, J. : Implementation of a single cell double-emulsion droplet assay in a shared resource laboratory. CytoVirtual Interactive 2021 June 2021 Notes: Presented as a video poster at virtual conference