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Antonella Cianferoni, MD/PhD

Professor of Pediatrics (Allergy/Immunology) at the Children's Hospital of Philadelphia

Department: Pediatrics
Division: Allergy/Immunology


Graduate Group Affiliations


Contact Information

Children's Hospital of Philadelphia
1216H ARC Allergy Immunology
34th and Center Boulevard
Philadelphia, PA 19104-4399
Office: 2674267831
Lab Phone: 2672941952
Fax: 2674260363
Email: cianferonia@email.chop.edu


I3H Keywords

  • Allergy, Asthma, and Other Inflammatory Diseases

Education

  • MD (Medicine)
    University of Florence, Italy, 1996
  • PhD (Pediatric Immunology)
    University of Florence, Italy, 2004

Post-Graduate Training

  • Resident, Pediatrics
    A. Meyer Hospital, University of Florence, Italy, 1996 - 1997
  • Research Fellow
    Allergy and Immunology, Johns Hopkins University, Baltimore, MD, 1997 - 1999
  • Clinical Fellow
    Allergy and Immunology, Boston Children's Hospital and Brigham and Women's Hospital, Boston, MA, 2002 - 2005
  • Resident, Pediatrics
    Children's Hospital of Philadelphia, Philadelphia, PA, 2005 - 2007

Certifications

  • Italian Board of Pediatrics, 2002
  • American Board of Pediatrics - Pediatrics, 2007
  • American Board of Pediatrics - Allergy and Immunology, 2009

Description of Clinical Expertise

I am an experienced, ABAI certified, practicing pediatric allergist with a special clinical and research interest in food allergy.

From a clinical standpoint, biweekly attendance in Allergy Clinic provides me with a breadth of experience in atopic disease along with access to 10-12 potential study patients with EoE per month. Our Center for Pediatric Esophageal Disorders, run by my mentor Dr. Spergel, and of which I am part, follows the largest cohort of children with eosinophilic esophagitis in the nation, including over 1000 patients with confirmed esophageal biopsies.I haveonce monthly clinic focused on Eosinophilic Esophagitis

I am the medical Director of Food Allergy immunotherapy Program at CHOP a

I partecipate to develop our imunotolerance program of food allergy

Description of Research Expertise

I am a pediatric allergist and immunologist with an interest in human food allergy immunopathogenesis. While my interest in allergic disease has been long-standing and continuous, the path to my current position and research endeavors has involved numerous institutions, as well as shifts between scientific and clinical training opportunities. I began my research career as a medical student and pediatric resident in Italy. There, I clinically characterized several classical allergic diseases including anaphylaxis and atopic dermatitis. I completed a Ph.D. in Immunology and pursued various research training opportunities in the United States, including a research fellowship at Johns Hopkins and a fellowship in Allergy and Immunology at Children’s Hospital Boston. Today I am an Assistant Professor of Pediatrics at The Children’s Hospital of Philadelphia (CHOP) where I study the role of iNKT cells in food allergy pathogenesis.
The above-mentioned training opportunities afforded me a variety of research experiences as well as exposure to a broad range of research styles, techniques and experimental paradigms; looked at purely from a publication productivity standpoint, however, the short-term nature of many of these experiences (on average 2 years in duration) was somewhat limiting. As I initiated each of the research projects I pursued, each, on average, resulted in only one first author publication. For example, at Hopkins, I studied the effect of aspirin on IL-4 transcription using a human cellular model (10), whereas at Boston Children’s I worked on IL-2 transcription using a mouse model of Wiskott-Aldrich Disease (21). These research experiences were separated by 3 years of clinical activity in Italy where I completed my Residency in Pediatrics. Following my research in Boston, I again shifted to clinical training, completing 3 years of clinical training in Pediatrics and Allergy and Immunology. Completion of this clinical work was required for U.S. Board Certification. Beginning with my appointment as Assistant Professor of Pediatrics at CHOP, I have been able to resume my research activities. Rather than continue research started at either Hopkins or Boston Children’s, however, I have chosen to focus my research efforts on a novel line of inquiry in food allergy. Today, my laboratory strives to understand how food-derived lipids contribute to food allergy sensitization, and in particular, how these lipids influence chronic atopic states like eosinophilic esophagitis (EoE) by activating iNKTs. To this end, I have developed state-of-the-art techniques to investigate, at a molecular level, this rare cell population in humans. This research led me to obtain NIH funding (K12 first for 2 years and more recently a K08 grant) a senior publication on JACI, coauthoira Nature a nature genetics paper and data for 4 more publications that are being submitted.

Our paper , for the first time, demonstrated that milk-derived lipids activate iNKTs via the TCR to produce Th2 cytokines, and that qualitative and quantitative differences in iNKTs exist between children with food allergies and their healthy counterparts. Our current research focuses on defining the role of iNKTs in Food allergy using the Eosinophilic Esophagitis model boith in human and in animals, as iNKTs appear to favor the development of other atopic diseases such as asthma and contact dermatitis, I anticipate that these studies will provide generalizable insights into how iNKT cells can be modulated to enhance treatment of patients with food allergies.

The dynamic and rich research environments at CHOP and the University of Pennsylvania have provided me with a wealth of mentors and collaborators, including leaders in the fields of iNKT, NK cell and T cell biology (Dr. Koretsky, Professor, Pathology and Laboratory Medicine University of Pennsylvania School of Medicine, Investigator and Director, Signal Transduction Program; Dr. Nichols, Associate Professor of Pediatrics, University of Pennsylvania, Oncology Division; and Dr. Orange Associate Professor of Pediatrics University of Pennsylvania, Allergy and Immunology Division). Additionally, I have capitalized on my prior research experiences and training to involve mentors from outside institutions (Dr. Brenner, Theodore B. Bayles Professor, Department of Medicine, Harvard Medical School Chief, Rheumatology, Immunology and Allergy, Brigham And Women's Hospital and Dr Boyson, Associate Professor, Associate Professor of Surgery and Director of Surgical Research, University of Vermont).

Description of ITMAT Expertise

Dr. Cianferoni is conducting translational research in allergies with a specific interest in food allergies, targeting the pathogenesis of food allergies using human blood sample from patients, normal donors and animal models.

Selected Publications

  • Anvari S, Baker MG, Bingemann T, Bird JA, Brown-Whitehorn T, Cianferoni A, Durban R, Gupta M, Hosein E, Konstantinou G, Leonard S, Ruffner MA, Schaible A, Scurlock AM, Varshney P, Muraro A, Fiocchi A, Santos AF, Arasi S, Vazquez-Ortiz M, Morita H, Nomura I, Upton JEM, Levin M, Lee E, Galvan C, Hoyos-Bachiloglu R, Chatchatee P, Beyer K, du Toit G, Gonzalez-Delgado P, Wong LSY, Groetch M, Nowak-Wegrzyn A. : Age-Appropriate Low Dosing for FPIES Oral Food Challenges: Proposing a Standardized Approach J Allergy Clin Immunol Pract Apr 2026
  • Canonica GW, Ortega-Martell JA, Villarreal-González RV, Ansotegui IJ, Bachert C, Bernstein J, Bleecker E, Bondi B, Caminati M, Carr T, Cianferoni A, González ID, Díaz SG, Gómez RM, Hanania N, Heffler E, Nair P, Öztop N, Park HS, Pitè H, Rouadi P, Saito H, Triggiani M, Varricchi G, Virchow C, Yamada Y, Yáñez A, Morais-Almeida M. : What is new on the horizon for the biologics world: New kids of the block - WAO state of art World Allergy Organ J 19 : 101349, Mar 2026
  • Buckey TM, Frangiosa J, Diem L, Hanna E, Datta R, Gober L, Brown-Whitehorn T, Spergel JM, Muir A, Cianferoni A. : Eosinophilic Esophagitis Incidence during Single and Multiple Food Oral Immunotherapy Ann Allergy Asthma Immunol Feb 2026
  • Wong LSY, Cox A, Cianferoni A, Katelaris C, Ebo DG, Konstantinou GN, Brucker H, Protudjer JLP, Hsu Blatman KS, Boechat JL, Yu JE, Wang J, Blazowski L, Anand MP, Torres MJ, Holbreich M, Wasserman RL, Sato S, Al-Shaikhly T, Yang HJ, Skypala IJ, Nowak-Wegrzyn A. : Pollen Food Allergy Syndrome-Two Decades Apart: A Follow-up AAAAI Survey J Allergy Clin Immunol Pract 2026
  • Arasi S, Morais-Almeida M, Martin BL, Wing-Kin Wong G, Ansotegui IJ, Ebisawa M, Custovic A, Santos A, Nowak-Wegrzyn A, Stoddart A, Deschildre A, Cianferoni A, Muraro A, DunnGalvin A, Vickery B, Venter C, Jones C, Mazzuca C, Warren C, Munblit D, Peden DB, Fleischer D, Hossny E, Roberts G, Szajewska H, Brough HA, Sublett JL, Bernstein JA, Ortega-Martell JA, Wang LL, Tanno LK, Caraballo L, Chikhladze M, Podestà M, Shaker MS, Guzmán Meléndez MA, Said M, Vazquez-Ortiz M, Bozzola M, Greenhawt M, Levin M, Lozano MÁ, Papadopoulos NG, Monge Ortega OP, Turner PJ, Kauppi P, Giavina-Bianchi P, Rouadi PW, Bégin P, Eigenmann P, Gómez RM, Boyle RJ, Gupta RS, Sindher SB, Chinthrajah RS, Winders T, Nurmatov U, Cardona V, Chang YS, Gerdts J, Rapillo R, Del Guidice MM, Patella V, Fiocchi A, Dahdah L. : Food allergy severity across the world: A World Allergy Organization international survey World Allergy Organ J 18 : 101123, Nov 2025
  • Albert J Bredenoorda, Evan S Dellonb, Christoph Schlagc, Antonella Cianferonid, Changming Xiae, Tiffany Pelaf, Sandy Durranie, Amr Radwane and Juby A Jacob-Naraf : Dupilumab is efficacious for eosinophilic esophagitis irrespective of prior swallowed budesonide or fluticasone, or prior treatments used alongside swallowed topical corticosteroids: results from the phase 3, randomized, placebo-controlled, LIBERTY EoE TREET trial Expert Review of Gastroenterology & Hepatology : in press, Jan 2025
  • Anagnostou A, Cianferoni A : 10 Ways to Improve Your Management of Food Allergy Annales of Asthma Allergy and Immunology : in press, Jan 2025
  • Rosan Meyer, Antonella Cianferoni3, Marta Vazquez-Ortiz : An Update on the Diagnosis and Management of Non-IgE mediated Food Allergies in Children Pediatric Allergy immunology : in press, Jan 2025
  • Klimek L, Brough HA, Arasi S, Toppila-Salmi S, Bergmann C, Jutel M, Bousquet J, Hox V, Gevaert P, Tomazic PV, Rondón Segovia C, Cingi C, Cuevas M, Gröger M, Huber P, Reitsma S, Rudenko M, Maza-Solano J, Gane S, Karavelia A, van Gerven L, Schiappoli M, Bozkurt B, Becker S, Chaker A, Wollenberg B, Mösges R, Huppertz T, Hagemann J, Palomares O, Bärhold F, Pfaar O, Del Giacco S, Bonadonna P, Moreira A, Agache I, Akdis CA, Fokkens W, Walusiak-Skorupa J, de Las Vecillas L, Alvaro Lozano M, Giovannini M, Untersmayr E, Feleszko W, Cianferoni A, Sahiner UM, Eguiluz-Gracia I, Shamji M, Torres Jaén MJ : Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity-An EAACI Position Paper Allergy 2025
  • Cardinale F, Taietti I, Sgrulletti M, Pacillo L, Moschese V, Cancrini C, Badolato R, Miraglia Del Giudice M, Marseglia GL, Chiappini E, Castagnoli R; Primary Atopic Disorders Working Group; Italian Society of Pediatric Allergy and Immunology (SIAIP). : Italian pediatric experts' consensus statement on diagnosis and management of primary atopic disorders Pediatr Allergy Immunol 2025