Ahmed Diab, PhD
Assistant Professor of Otorhinolaryngology: Head and Neck Surgery

- Member, Institute for Immunology & Immune Health (I3H)
- Core Member, Center for Genome Integrity
- Member, Abramson Cancer Center Cancer Therapeutics Program
- Member, Institute of Translational Medicine and Therapeutics
Department: Otorhinolaryngology: Head and Neck Surgery
Contact Information
Department of Otorhinolaryngology, Head and Neck Surgery
Perelman School of Medicine at the University of Pennsylvania
Biomedical Research Building BRB1209
421 Curie Blvd
Philadelphia, PA 19104
Email: ahmed.diab@pennmedicine.upenn.edu
I3H Keywords
- Array
Publications
Links
Education
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B.S. (Biology, Minor in Chemistry, Magna Cum Laude)
The American University in Cairo (AUC), Egypt, 2010 -
M.S. (Biosciences)
King Abdullah University of Science and Technology (KAUST), Kingdom of Saudi Arabia, 2011 -
Ph.D. (Cancer Biology)
Purdue University, West Lafayette, IN, 2016
Post-Graduate Training
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Postdoctoral Fellow, Head and Neck Cancer
Fred Hutchinson Cancer Center, Advisor Eddie Mendez , 2016 - 2017 -
Postdoctoral Fellow, Head and Neck Cancer
Fred Hutchinson Cancer Center, Advisor Bruce Clurman , 2018 - 2021
Description of Research Expertise
Cancer Immunology and Immunotherapy
Tumor Microenvironment
Virology
Selected Publications
- Miller ZA, Muthuswami S, Mueller A, Ma RZ, Sywanycz SM, Naik A, Huang L, Brody RM, Diab A, Carey RM, Lee RJ. : GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells Cell Death Discov 10(1):339 July 2024
- Malay K. Sannigrahi, Lovely Raghav, Ahmed Diab, Devraj Basu : The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas Tumour Virus Research November 2024
- Thirimanne HN, Wu F, Janssens DH, Swanger J, Diab A, Feldman H, Amezquita RA, Gottardo R, Paddison PJ, Henikoff S, Clurman BE : Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations Elife 11 : e74338, Feb 2022
- Diab A, Gem H, Swanger J, Kim HY, Smith K, Zou G, Raju S, Kao m, Fitzgibbon M, Loeb KR, Rodriquez CP, Mendez E, Galloway DA, Sidorova JM, Clurman BE : FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition Proc Natl Acad Sci U S A 117(45) : 28287-28296, Nov 2020
- Diab A, Kao M, Kehrli K, Kim HY, Sidorova J, Mendez E : Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition Mol Cancer Res 17(5) : 1115-1128, May 2019
- Mendez E, Rodriquez CP, Kao MC, Raju S, Diab A, Harbison RA, Konnick EQ, Mugundu GM, Santana-Davila R, Martins R, Futran ND, Chow LQM : A Phase I Clinical Trial of AZD1775 in Combination with Neoadjuvant Weekly Docetaxel and Cisplatin before Definitive Therapy in Head and Neck Squamous Cell Carcinoma Clin Cancer Res 24(12) : 2740-2748, Jun 2018
- Diab A, Foca A, Zoulim F, Durantel D, Andrisani O : The diverse functions of the hepatitis B core/capsid protein (HBc) in the viral life cycle: Implications for the development of HBc-targeting antivirals Antiviral Res 149 : 211-220, Jan 2018
- Diab A, Foca A, Fusil F, Lahlali T, Jalaguier P, Amirache F, N'Guyen L, Isorce N, Cosset FL, Zoulim F, Andrisani O, Durantel D : Polo-like-kinase 1 is a proviral host factor for hepatitis B virus replication Hepatology 66(6) : 1750-1765, Dec 2017
- Fan H, Cui Z, Zhang H, Mani SK, Diab A, Lefrancois L, Fares N, Merle P, Andrisani O : DNA demethylation induces SALL4 gene re-expression in subgroups of hepatocellular carcinoma associated with Hepatitis B or C virus infection Oncogene 36(17) : 2435-2445, Apr 2017
- Mani SK, Zhang H, Diab A, Pascuzzi PE, Lefancois L, Fares N, Bancel B, Merle P, Andrisani O : EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes J Hepatol 65(5) : 888-898, Nov 2016