Meet Cyclone: A Monitoring Tool That Watches for Waves of Immune Response

A Penn Medicine research team recently developed a new algorithm called Cyclone that detects when immunotherapies create surges of T cell responses in melanoma patients. “We wanted to create a monitoring tool that helps clinicians understand what is going on in the patient at a precise level, rather than looking at serial CT scans to see if the tumor grew or shrank,” said Kevin Wang, a medical student in the Perelman School of Medicine, lead author of the study, and member of Alexander Huang, MD’s laboratory.