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Recognition
- Saar Gill Appointed PICI Co-Director
- A Multivalent mRNA-LNP Vaccine Protects Against Clostridioides Difficile Infection
- Uncovering New Antibiotics
- Maintenance of X Chromosome Inactivation After T Cell Activation Requires NF-κB Signaling
- LAG-3 and PD-1 Synergize on CD8+ T Cells to Drive T-cell Exhaustion and Hinder Autocrine IFN-γ-dependent Anti-tumor Immunity
- MrgprA3 Neurons Drive Cutaneous Immunity Against Helminths Through Selective Control of Myeloid-Derived IL-33
- CD45 Threads the Needle of Cytokine Cancer Immunotherapy
- Fast and Facile Synthesis of Amidine-Incorporated Degradable Lipids for Versatile mRNA Delivery In Vivo
- Mosaic Sarbecovirus Nanoparticles Elicit Cross-Reactive Responses in Pre-Vaccinated Animals
- Mining Human Microbiomes Reveals an Untapped Source of Peptide Antibiotics
- Granulocyte Colony Stimulating Factor Promotes Scarless Tissue Regeneration
- Microbial Colonization Programs are Structured by Breastfeeding and Guide Healthy Respiratory Development
- Cytokine-Mediated CAR T Therapy Resistance in AML
- Enhancing Cellular Immunotherapies in Cancer by Engineering Selective Therapeutic Resistance
- Tumour-Derived Small Extracellular Vesicles Act as a Barrier to Therapeutic Nanoparticle Delivery
- ATM-Dependent Phosphorylation of Nemo SQ Motifs Is Dispensable for Nemo-Mediated Gene Expression Changes in Response to DNA Double-Strand Breaks
- YY1-Controlled Regulatory Connectivity and Transcription are Influenced by the Cell Cycle
- Directing Risky Traffic in B Cells with TNIP1
- Myosin-I Synergizes with Arp2/3 Complex to Enhance the Pushing Forces of Branched Actin Networks
- Single-Cell CAR T Atlas Reveals Type 2 Function in 8-Year Leukaemia Remission
- Off-the-Shelf CAR-T Cells Could Prove Paradigm Shifting for Autoimmune Diseases
- Cloning and Functional Characterization of Novel Human Neutralizing Anti-IFN-α and Anti-IFN-β Antibodies
- Alternating High-Fat Diet Enhances Atherosclerosis by Neutrophil Reprogramming
- The Drugs of the Future Are in the Animals of the Past
- Tumor Fighter
- Diabetic Wounds
- AACR Grant Propels Progress in Immunotherapy Research
- CAR-T Attack in Pancreatic Tumors Boosted By Proton Vanguard
- Scientists Wary of Bird Flu Pandemic ‘Unfolding in Slow Motion’
- CAR T-Cell Therapy’s Risks and Benefits are Becoming Clearer
- Father of CAR T-Cell Therapy Sees 2024 as a Breakthrough Year for Brain Cancer Treatment
- A Mammoth Antibiotic Advance
- Five Ways Science Is Tackling the Antibiotic Resistance Crisis
- Removing CD5 ‘Brake’ on CAR T Cells Increases Antitumor Efficacy
- 25 Visionaries Forging the Future of Artificial Intelligence
- West Philadelphia: Laboratory of the World
- Your Gut Could Be Source of Powerful New Antibiotics
- Penn and Parker Institute Renew Multimillion-Dollar Cancer Research Collaboration
- Three From Penn Elected to The American Philosophical Society
- The Next Frontier for mRNA Could Be Healing Damaged Organs
- Gut Microbes’ Genomes Are a Trove of Potential Antibiotics
- Removing CD5 Gene Improves CAR-T Expansion, Antitumor Capabilities
- Looking Back, Looking Forward: Penn’s CAR-T Program Continues Path of Progress
- New Research Might Improve CAR-T Bioprocessing
- Advancing CAR-T Therapy With CD5 Modulation
- Outpatient CAR T-Cell Therapy in Action
- Understanding the Cellular Mechanisms Driving Solid Tumors’ Robust Defense System
- Molecular ‘De-Extinction’ Sparks the Imagination
- Combo Immunotherapy Produces Distinct Waves of Cancer-Fighting T Cells
- How Immunotherapy Fights Leukemia, Lymphoma, and Multiple Myeloma
- How Should You Time COVID Boosters, Flu Shots, RSV Vaccine This Fall?
- Data Gaps Leave Researchers Unsure Whether Bird Flu Is Spreading Among People
- This Doctor Saved His Own Life. Now He’s on a Mission to Save Thousands More
- Nobel Prizes Are Coming Next Week – Meet Penn Medicine Contenders
- WebMD Health Heroes: David Fajgenbaum, MD, MBA
- Jurassic Park on the Schuylkill
- Antibiotic Resistance Threatens to Kill 208 Million People in 25 Years
- A Year After the Nobel Prize, Penn’s mRNA Research Is Revving Up
- Lifetime Achievement Award
- Borrelli Family Lynch Syndrome Pilot Awardee 2024
- Heritage Lecture Awardee
- Fellow of the American Association for Cancer Research 2024
- Citizen of the Year Awards: Dr. David C. Fajgenbaum
- CAR T-Cell-Mediated Delivery of Bispecific Innate Immune Cell Engagers for Neuroblastoma
- The Genomic Basis of Childhood T-lineage Acute Lymphoblastic Leukaemia
- Targeting RSV-Neutralizing B Cell Receptors With Anti-Idiotypic Antibodies
- Advances and Ongoing Challenges in Eosinophilic Gastrointestinal Disorders Presented at the CEGIR/TIGERs Symposium at the 2024 American Academy of Allergy, Asthma & Immunology Meeting
- Women in STEM Becoming Independent: Our Shared Motivation and Enthusiasm Are Our Driving Force
- Human Red Blood Cells Express the RNA Sensor TLR7
- Recruitment of CXCR4+ Type 1 Innate Lymphoid Cells Distinguishes Sarcoidosis From Other Skin Granulomatous Diseases
- IL-12 Drives the Differentiation of Human T Follicular Regulatory Cells
- Combination Anti-PD-1 and Anti-CTLA-4 Therapy Generates Waves of Clonal Responses That Include Progenitor-Exhausted CD8+ T Cells
- Targeting TGFβ-Activated Kinase-1 Activation in Microglia Reduces CAR T Immune Effector Cell-Associated Neurotoxicity Syndrome
- OLAH Connects Fatty Acid Metabolism to the Severity of Respiratory Viral Disease
- In Utero Delivery of Targeted Ionizable Lipid Nanoparticles Facilitates In Vivo Gene Editing of Hematopoietic Stem Cells
- Lipid-Mediated Intracellular Delivery of Recombinant bioPROTACs for the Rapid Degradation of Undruggable Proteins
- PI3Kγ in B Cells Promotes Antibody Responses and Generation of Antibody-Secreting Cells
- LAG-3 Sustains TOX Expression and Regulates the CD94/NKG2-Qa-1b Axis to Govern Exhausted CD8 T Cell NK Receptor Expression and Cytotoxicity
- DCAF15 Control of Cohesin Dynamics Sustains Acute Myeloid Leukemia
- Wriggly Woes: Helminths Stirring Up T Cell Trouble
- Mast Cell Secretory Granule Fusion With Amphisomes Coordinates Their Homotypic Fusion and Release of Exosomes
- Distinct SIV-Specific CD8+ T Cells in the Lymph Node Exhibit Simultaneous Effector and Stem-Like Profiles and Are Associated With Limited SIV Persistence
- Genetic and Environmental Interactions Contribute to Immune Variation in Rewilded Mice
- Use of 3M-052-AF With Alum Adjuvant in HIV Trimer Vaccine Induces Human Autologous Neutralizing Antibodies
- Clonal Hematopoiesis Driven by Mutated DNMT3A Promotes Inflammatory Bone Loss
- Intestinal cDC1s Provide Cues Required for CD4+ T Cell-Mediated Resistance to Cryptosporidium
- CAR T Cell Combination Therapies to Treat Cancer
- Proton Radiation Boosts the Efficacy of Mesothelin-Targeting Chimeric Antigen Receptor T Cell Therapy in Pancreatic Cancer
- Immunologic Signatures of Response and Resistance to Nivolumab With Ipilimumab in Advanced Metastatic Cancer
- Modified C-Type Natriuretic Peptide Normalizes Tumor Vasculature, Reinvigorates Antitumor Immunity, and Improves Solid Tumor Therapies
- Two Clinical Trials Assessing Treatments for Eosinophilic Esophagitis
- Transdifferentiation Occurs Without Resetting Development-Specific DNA Methylation, a Key Determinant of Full-Function Cell Identity
- Senescent Cancer-Associated Fibroblasts in Pancreatic Adenocarcinoma Restrict CD8+ T Cell Activation and Limit Responsiveness to Immunotherapy in Mice
- An Iron-Rich Subset of Macrophages Promotes Tumor Growth Through a Bach1-Ednrb Axis
- Circulating KRAS G12D But Not G12V is Associated With Survival in Metastatic Pancreatic Ductal Adenocarcinoma
- Improved Influenza Vaccine Responses After Expression of Multiple Viral Glycoproteins From a Single mRNA
- Siloxane-Enhanced Nanoparticles Chart a New Path in Precision mRNA Medicine
- Scientific Discovery Scratching Beneath the Surface of Itchiness
- Uncovering a Way for Pro-B Cells to Change Trajectory
- Pioneer vaccine
- Prestigious honor
- Novel Techniques May Provide ‘Incredible’ Benefits to Enhance CAR T-Cell Therapy
- Researchers At Health Institutions Like Penn Medicine Are Testing Vaccines to Prevent Cancer
- Two Penn Medicine Leaders Make Philly Mag's Most Influential List
- What To Expect From Uv Light Therapy for Your Scalp
- As Bird Flu Spreads, Additional Human Infection Is Reported in Missouri
- Research Uncovers Antibiotics Hidden in Proteins of Systems Other Than the Immune System
- Of Medicine and Miracles
- University of Pennsylvania Gene Therapy Spinout Interius BioTherapeutics Doses Patient, Achieves CAR Therapy First
- Meet Cyclone: A Monitoring Tool That Watches for Waves of Immune Response
- Non-Immune Proteins Harbor Antimicrobial Agents
- Secrets of CAR T Cell Longevity
- X’d-Out: X Chromosome Tied to Sex-Based Immune Differences
- Penn Medicine Pair Honored by American Society for Microbiology
- Grant Awarded for Maximizing CAR T in Ovarian Cancer Treatment
- Can We Prevent Cancer With a Shot?
- After Nobel Prize, Penn’s mRNA Research Revving Up
- Penn Research Modifies COVID Vaccines to Target C. Diff
- Carl June Awarded the Abarca Prize for CAR T Cell Therapy Research
- Antimicrobial resistance
- How Durable Are the mRNA COVID Vaccines?
- Does It Matter What Time You Take Your Medicine?
- New mRNA Vaccine Prevents C difficile in Mice
- T Cell Therapy Now Taking Aim at Autoimmune Disease
- Borrowing a Page from Cancer’s Playbook, Scientists Learn to Evade their Own Therapies
- H5N1 Bird Flu Virus in Canadian Displays Mutations Demonstrating Virus’ Risk
- A Conversation with Dr. Robert Vonderheide of Penn Medicine’s Abramson Cancer Center
- Why a Teenager’s Bird-Flu Infection is Ringing Alarm Bells for Scientists
- How Interdisciplinary Science Can Change the World
- Douglas B. Cines Honored with Henry M. Stratton Medal for Outstanding Contributions to Hematology
- Dietary Changes May Improve Blood Cancer Outcomes
- Biopharma Takes on Deadly Brain Cancer After Decades of Failure
- Worth Magazine’s ‘Worthy 100’ 2024
- Navigating a ‘Revolutionary Era’ of Targeted Therapy in Pancreatic Cancer
- Harnessing the Power of the Immune System for Breast Cancer Treatment
- Why Have U.S. Bird Flu Cases Been So Mild?
- A Beneficial Bacterium Helps Wounds Heal
- Ketogenic Diet May Enhance CAR T Cell Therapy Efficacy
- An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung
- Glutamine is critical for the maintenance of type 1 conventional dendritic cells in normal tissue and the tumor microenvironment
- CAR T cells in autoimmune disease: On the road to remission
- Cytokine-mediated CAR T therapy resistance in AML
- Share Natural TCRs targeting KRASG12V display fine specificity and sensitivity to human solid tumors.
- Red Blood Cells Capture and Deliver Bacterial DNA to Drive Host Responses During Polymicrobial Sepsis
- Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study
- Prime Editor Gene Therapy and TREX1 Mosaicism in Retinal Vasculopathy with Cerebral Leukoencephalopathy
- Targeting peptide antigens using a multiallelic MHC I-binding system
- Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia
- Native stem cell transcriptional circuits define cardinal features of high-risk leukemia.
- pDCs, type 1 IFN, and the female predileXion of SSc.
- ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation.
- EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models.
- CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in TP53.
- Identifying and Targeting TNF Signaling in Idiopathic Multicentric Castleman's Disease.
- FLASH radiation reprograms lipid metabolism and macrophage immunity and sensitizes medulloblastoma to CAR-T cell therapy.
- Disease diagnostics using machine learning of B cell and T cell receptor sequences.
- Afraid of needles? Try lotion: Engineering skin commensals for vaccination.
- Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis.
- Neomorphic leukemia-derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine.
- Automated cytometric gating with human-level performance using bivariate segmentation.
- Functional evaluation and clinical classification of BRCA2 variants.
- Safer non-viral DNA delivery using lipid nanoparticles loaded with endogenous anti-inflammatory lipids.
- Virologic effects of broadly neutralizing antibodies VRC01LS and VRC07-523LS on chronic HIV-1 infection.
- DNA immunotherapy for recurrent respiratory papillomatosis (RRP): phase 1/2 study assessing efficacy, safety, and immunogenicity of INO-3107.
- Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers.
- Double-strand break repair pathways differentially affect processing and transduction by dual AAV vectors.
- Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History.
- Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies.
- Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution.
- The heterogeneity of neutrophils in cancer and its implication for therapeutic targeting.
- Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.
- Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial.
- Multiparametric MRI along with machine learning predicts prognosis and treatment response in pediatric low-grade glioma
- Mitochondrial DNA lineages determine tumor progression through T cell reactive oxygen signaling.
- Distinct myeloid-derived suppressor cell populations in human glioblastoma.
- SLE B cells take an extrafollicular detour after mRNA vaccination.
- Brain-wide neuronal circuit connectome of human glioblastoma.
- Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior.
- The global H5N1 influenza panzootic in mammals.
- Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: an individual data-based meta-analysis of 24 prospective studies.
- CryoEM structure of an MHC-I/TAPBPR peptide-bound intermediate reveals the mechanism of antigen proofreading.
- Bird Flu in Patient Shows Mutations Likely Gained Post-Infection
- Five of the Most Important Medical Breakthroughs of 2024
- mRNA Vaccine Shows Potential for C difficile Infections
- Studies Point to the Role of Diet in Hematologic Malignancies
- Scientists Are Racing to Develop a New Bird Flu Vaccine
- The Future of Cancer Genetics Is Here
- How to Prevent Bird Flu from Becoming the Next Pandemic
- Red-Light Hats and $2,700 Laser Kits: The Evolution of At-Home Beauty
- Breaking barriers
- Improving Access to CAR T Cell Therapy for Minority Patients with Multiple Myeloma
- New Research on BRCA Mutations and Breast Cancer
- Lessons Learned in Cell Therapy for Autoimmune Disease
- AI Is Coming Up with Brand New Molecules, Fueling Drug Discovery
- Bird flu explained
- From CAR T-Cell Therapy to the Impact of Mentorship
- Terminally Ill Patient ‘Cured’ of Immune Illness After AI IDs Drug for ‘Repurposing’
- Cows Have Been Infected with a Second Form of Bird Flu
- Flu Cases Are Surging This Year
- CAR T therapy
- Celiac disease
- Sloan Research Fellows
- Scientists Describe Rare Syndrome Following Covid Vaccinations
- Grant Awarded to Advance Gastroesophageal Cancer Treatment
- Trillions of Viruses Live in Your Body. AI Is Trying to Find Them
- Penn-made AI Tool Aims to Treat Rare Diseases with Existing Drugs
- Key Sessions at the AACR Immunotherapy Conference
- Inside the Debate Over the Origins of COVID-19
- Study Suggests CAR T Cell Therapy May Work for Solid Tumors
- The Importance of Funding Medical Research
- Tanning Salon or Sun Spa? Why the Industry Is Expanding Spa Services
- Scientists Develop Bird Flu Vaccines in Preparation for Possible Pandemic
- Without Fundamental Science, How Would the Next Generation of Novel Therapies Emerge?
- The Importance of Clinical Trial and Treatment Accessibility for Myeloma
- Experts Raise “Serious Doubt” About COVID Vaccine Study Claiming mRNA Harms
- Measles Is Unlike Other Viruses: What to Know About Long-Term Complications
- H5N1 Immune Response Correlates with Birth Year
- Purified T Cell Transplant Lowers Risk of Immune Reaction in Blood Cancer Patients
- American Association for Cancer Research Honors Oncology Leaders
- Deucravacitinib Improves Cutaneous Lupus Erythematosus Activity
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