Senescent Cancer-Associated Fibroblasts in Pancreatic Adenocarcinoma Restrict CD8+ T Cell Activation and Limit Responsiveness to Immunotherapy in Mice

Assouline B, Kahn R, Hodali L, Condiotti R, Engel Y, Elyada E, Mordechai-Heyn T, Pitarresi JR, Atias D, Steinberg E, Bidany-Mizrahi T, Forkosh E, Katz LH, Benny O, Golan T, Hofree M, Stewart SA, Atlan KA, Zamir G, Stanger BZ, Berger M, Ben-Porath I.

Nat Commun. 2024 Jul 22;15(1):6162. PMID: 39039076